Drosophila RNAi Screening Center

Public DRSC Screens

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Cell Line Library Total Reagents Screened View Hits Download Hits Raw Data Assay Type PubMed PubChem Paper
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.
S2R+ Genome vs1 22534 1644 1644 97260 rows Fluorescence, Imaging 17086199 PDF
 
 
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.
S2R+ Genome vs1 21306 153 153 21061 rows Imaging 16511445 PDF
 
 
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
Kc Genome vs1 22534 18 18 37661 rows Luminescence 17517653 504808 PDF
 
 
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.
S2R+ Genome vs1 22914 476 476 48384 rows Luminescence 19942856 504716 PDF
 
 
A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.
DL2 Genome vs1 22914 20 20 356 rows Fluorescence 18042462 504807 PDF
 
 
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion.
S2R+ Genome vs2 23328 0 0 61440 rows Luminescence 21886182 PDF
 
 
A genome-wide RNAi screen reveals multiple regulators of caspase activation.
Kc Genome vs1 21306 47 47 39948 rows Luminescence 17998402 504804 PDF
 
 
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.
SL2 Genome vs1 22914 126 126 647 rows Imaging 20100940 504771 PDF
 
 
Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6.
Unknown Genome vs1 15606 17 17 331 rows Luminescence 19572019 504772 PDF
 
 
Biochemical and functional characterization of Orai proteins.
S2R+ Genome vs1 21091 24 24 24 rows Imaging 17293345 504802 PDF
 
 
Cell Cycle-dependent Mechanism Controlling Centromere
Kc Genome vs1 22534 6 6 983 rows Imaging
 
 
Comparative Analysis of Argonaute-Dependent Small RNA Pathways in Drosophila,
S2 Genome vs1, Genome vs2 28868 199 199 75352 rows Luminescence 19026789 504791 PDF
 
 
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.
S2R+ Genome vs1 21306 2646 2646 2664 rows Imaging 21893601 PDF
 
 
Comparison of GPCR Induced vs. Small G-Protein Induced Signalling to the Nucleus
S2 Genome vs1, Genome vs2 17210 2335 2335 77568 rows Luminescence
 
 
COPI activity coupled with fatty acid biosynthesis is required for viral replication.
SL2 Genome vs1 22534 111 111 309 rows Imaging 17040126 PDF
 
 
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
S2 Genome vs1 22914 2069 2069 41611 rows Fluorescence 16645049 PDF
 
 
Definition of global and transcript-specific mRNA export pathways in metazoans.
S2R+ Genome vs1 22914 83 83 922 rows Imaging 18086857 504805 PDF
 
 
Discovery of insect and human dengue virus host factors.
S2 Genome vs2 22632 520 520 47452 rows Imaging 19396146 504761 PDF
 
 
Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia.
S2 Genome vs1 21306 609 609 70944 rows Luminescence 20585616 504786 PDF
 
 
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.
S2 Genome vs1 22914 82 82 143 rows Imaging 16020694 PDF
 
 
Dynamic Switch of Negative Feedback Regulation in Drosophila Akt-TOR Signaling.
Unknown Genome vs1 22534 1137 1137 94464 rows Fluorescence 20585550 504744 PDF
 
 
ER retention of the cleaved EGFR ligand Spitz
S2R+ Genome vs1 13536 263 263 263 rows Imaging
 
 
False negative rates in Drosophila cell-based RNAi screens: A case study.
S2R+ KP, KPvs2, NCRNA 1809 5 5 6912 rows Luminescence 21251254 504711 PDF
 
 
Flockhouse Virus
Unknown Genome vs1, Genome vs2 17079 426 426 569 rows Imaging
 
 
Functional genomic analysis of the Wnt-wingless signaling pathway.
clone 8 Genome vs1 22534 233 233 28709 rows Luminescence 15817814 PDF
 
 
Functional genomics reveals genes involved in protein secretion and Golgi organization.
S2 Genome vs1 22534 1068 1068 47650 rows Luminescence 16452979 PDF
 
 
Genes involved in store-operated calcium entry
S2 Genome vs1 22914 75 75 53762 rows Fluorescence
 
 
Genes regulating lipid storage in Drosophila melanogaster
Kc Genome vs1, Genome vs2 17210 736 736 37803 rows Imaging
 
 
Genetic modifiers of cell survival following exposure to DNA damaging agents
Kc, S2 Genome vs1 22914 109 109 356832 rows Luminescence
 
 
Genome-wide RNAi analysis of growth and viability in Drosophila cells.
Kc, S2R+, SL2 Genome vs1 21306 429 429 84920 rows Luminescence 14764878 493246 PDF
 
 
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.
S2* Genome vs1 22534 120 120 40738 rows Luminescence 16055650 PDF
 
 
Genome-wide RNAi screen for genetic modifiers of Mitotane (o.p'-DDD) cytotoxicity in Drosophila Kc167 cells
Kc Genome vs2 22632 0 0 152448 rows Luminescence
 
 
Genome-wide RNAi screen for host factors required for intracellular bacterial infection.
SL2 Genome vs1 22534 311 311 23123 rows Imaging 16020693 504811 PDF
 
 
Genome-wide RNAi Screen for Rb-synthetic Lethal Genes
S2* Genome vs1 22914 30 30 33 rows Luminescence
 
 
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
S2 Genome vs2 22632 723 723 50305 rows Fluorescence 19797662 504721 PDF
 
 
Genome-wide screen for genes involved in microRNA biogenesis and siRNA activity
S2R+ Genome vs2 22502 0 0 49920 rows Fluorescence
 
 
Hedghog secretion
S2 Genome vs1 22914 1199 1199 56448 rows Luminescence
 
 
Hh Signalling
clone 8 Genome vs1 22534 503 503 43465 rows Luminescence
 
 
High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model.
Primary KP, KPvs2 1361 0 0 0 rows Imaging 21909362 PDF
 
 
Host Factors Required for Modulation of Phagosome Biogenesis and Proliferation of Francisella tularensis within the Cytosol.
S2R+ Genome vs2 23325 467 467 52606 rows Fluorescence 20552012 504705 PDF
 
 
Identification of co-factors and target genes required for FOXO-induced muscle atrophy in D. melanogaster
BG2 TF 1803 0 0 15944 rows Imaging
 
 
Identification of genes required for HOW-dependent RNA degradation
S2R+ Genome vs1 15257 680 680 32640 rows Fluorescence
 
 
Identification of neural outgrowth genes using genome-wide RNAi.
Primary Genome vs1 22534 136 136 2632 rows Imaging 18604272 504795 PDF
 
 
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.
S2R+ Genome vs1 21306 170 170 93142 rows Luminescence 18519643 504794 PDF
 
 
Identifying factors that regulate the recruitment and function of the dosage compensation complex in Drosophila melanogaster.
SL2 Genome vs1, Genome vs2 22520 0 0 360 rows Luminescence
 
 
Identifying modulators for the mammalian nuclear hormone receptor RORgamma-t
S2 Genome vs2 22547 0 0 52608 rows Luminescence
 
 
Interactions between Legionella pneumophila and its host
Unknown Genome vs2 12464 617 617 12288 rows Fluorescence
 
 
Kc Cell Morphology
Kc Genome vs1 22534 226 226 369 rows Imaging
 
 
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
S2 Genome vs1 22914 134 134 0 rows Imaging 18662975 PDF
 
 
Modifiers of Notch Signalling
Kc Genome vs1 22534 684 684 22670 rows Luminescence
 
 
Molecular circadian clock in Drosophila
S2 Genome vs1 22534 31 31 52224 rows Luminescence
 
 
Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads.
S2 Genome vs1 22534 2165 2165 0 rows Imaging 17785517 PDF
 
 
Nuclear targeting factors of MAD-Follow Up
S2R+ Genome vs2 22491 0 0 24934 rows Imaging
 
 
p53
S2 Genome vs1 22914 785 785 248448 rows Luminescence
 
 
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
Kc Genome vs1 21306 220 220 222 rows Imaging 15547975 PDF
 
 
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.
Unknown KP, KPvs2, TF 3131 17 17 4943 rows Imaging 18927396 PDF
 
 
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.
Kc Genome vs2 22491 1509 1509 95237 rows Fluorescence 22028469 PDF
 
 
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.
S2R+ Genome vs1 22534 1671 1671 95232 rows Fluorescence, Imaging 22028469 PDF
 
 
PVR modifier screen
Kc Genome vs1, MK 22535 470 470 85630 rows Luminescence
 
 
Regulators of X-chromosome dosage compensation
SL2 Genome vs1 22534 79 79 306 rows Imaging
 
 
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance.
Primary Genome vs1, Genome vs2 22534 50 50 1049 rows Imaging 18359903 504798 PDF
 
 
RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection.
S2 Genome vs1 15609 160 160 489 rows Imaging 17967059 PDF
 
 
Screen for novel regulators of G2/M checkpoint
S2 Genome vs2, KP, KPvs2 23068 115 115 23807 rows Imaging
 
 
Synthetic-lethal interactions with oncogenic Ras
S2 Genome vs2 22491 0 0 95229 rows Luminescence
 
 
The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells
S2R+ Genome vs1 22534 27 27 789 rows Imaging
 
 
Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis.
S2 Genome vs1 22914 369 369 718 rows Imaging 18984163 PDF
 
 
VSV Screen
SL2 Genome vs1 22534 552 552 674 rows Imaging
 
 


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