upd1 - dome

chain A = FBgn0004956 , chain B = FBgn0043903

Rank Table

Rank 1
id Rank/Model Chain Protein 1 Protein 2 Score fbgn1 fbgn2 ncbi_gene_id1 ncbi_gene_id2 Symbol 1 Symbol 2 protein_1_size protein_2_size iLIS iLIA iLISA ipSAE actifpTM ipTM LIS cLIS LIR i/j cLIR i/j LIS (AB) LIS (BA) LIA (AB) LIA (BA) LIA LIR (A) LIR (B) LIR LIpLDDT (A) LIpLDDT (B) LIpLDDT cLIS (AB) cLIS (BA) cLIA (AB) cLIA (BA) cLIA cLIR (A) cLIR (B) cLIR cLIpLDDT (A) cLIpLDDT (B) cLIpLDDT LIR Indice A LIR Indice B cLIR Indice A cLIR Indice B Confidence pae_file_name directory_name output_file_name enrichment_id1 enrichment_id2 pLDDT pTM Len A Len B
29060 1 / 4 A / B upd1 dome 12 / 15 FBgn0004956 FBgn0043903 32813 32976 upd1 dome full full 0.529 2655.2 1405 0.625 0.992 0.57 0.384 0.729 223 / 325 21 / 24 0.408 0.36 37919 41293 79212 223 325 548 76.198 88.62 83.565 0.764 0.694 44 45 89 21 24 45 81.018 80.272 80.62 ["77-105","114-238","255-281","288-327"] ["20-329","356-366","368","408"] ["79-80","149-154","156-157","200-204","272","274","277","298"] ["23-27","57","59","103","105","107-108","110-113","115","152","154","173-176"] 0.544 upd1___dome_scores_rank_001_alphafold2_multimer_v3_model_4_seed_000.json SET_69 59.343 0.44 413 1282
29061 2 / 1 A / B upd1 dome 10 / 15 FBgn0004956 FBgn0043903 32813 32976 upd1 dome full full 0.435 1950.1 847.5 0.491 0.976 0.52 0.298 0.633 201 / 258 18 / 23 0.32 0.277 20976 23764 44740 201 258 459 78.365 88.258 83.926 0.634 0.633 44 41 85 18 23 41 84.812 79.67 81.927 ["82-104","117-233","258-281","290-324"] ["20-186","190-227","231","233","242-246","249-250","252-254","257-264","285-289","292","297-308","311-323"] ["150-154","156-157","200-204","272","274","277","298"] ["23-27","60","103","105","107-108","110-113","115","152","154-155","173","175-176"] 0.498 upd1___dome_scores_rank_002_alphafold2_multimer_v3_model_1_seed_000.json SET_69 59.05 0.41 413 1282
29062 3 / 5 A / B upd1 dome 10 / 15 FBgn0004956 FBgn0043903 32813 32976 upd1 dome full full 0.398 1925.5 767 0.491 0.973 0.51 0.272 0.583 197 / 270 20 / 24 0.295 0.25 20363 23253 43616 197 270 467 77.483 88.158 83.655 0.608 0.558 43 42 85 20 24 44 80.277 80.22 80.246 ["80-101","117-230","232","258-280","290-324"] ["21-187","189-227","229-234","240-250","252-264","286-289","292","294","297-309","311-323"] ["80","149-154","156-157","200-204","272","274","277","298"] ["23-27","59","103","105","107-108","110-113","115","152","154-155","173-176"] 0.492 upd1___dome_scores_rank_003_alphafold2_multimer_v3_model_5_seed_000.json SET_69 58.379 0.42 413 1282
29063 4 / 3 A / B upd1 dome 10 / 15 FBgn0004956 FBgn0043903 32813 32976 upd1 dome full full 0.375 1889.2 708.3 0.443 0.968 0.51 0.257 0.546 196 / 257 20 / 23 0.274 0.24 18817 21285 40102 196 257 453 77.041 88.162 83.35 0.583 0.51 45 44 89 20 23 43 81.814 80.034 80.862 ["80-100","118-232","259-280","289-324"] ["21-187","189-190","193-227","231","233","241-246","249","252-253","257-264","271","287-289","292","297-323"] ["149-154","156-157","200-204","272","274","277-278","298"] ["23-27","59","103","105","107-108","110-113","115","152","154-155","173","175-176"] 0.494 upd1___dome_scores_rank_004_alphafold2_multimer_v3_model_3_seed_000.json SET_69 58.663 0.43 413 1282
29064 5 / 2 A / B upd1 dome 1 / 15 FBgn0004956 FBgn0043903 32813 32976 upd1 dome full full 0.127 545.3 69.4 0.018 0.753 0.42 0.086 0.188 137 / 175 22 / 12 0.076 0.096 768 3737 4505 137 175 312 79.392 88.908 84.729 0.177 0.2 35 31 66 22 12 34 71.161 76.87 73.176 ["81-83","92-135","158","160-161","170-191","193-196","207-208","210-234","259","261-268","270-271","273","300-319"] ["37-39","45","47","99","101","103-105","115","117-177","179-227","231","233","240-247","250-253","257-265","269","286-289","292","297-308","312-322"] ["100-110","112","126","130-131","216","219-220","223","227"] ["165-170","187-188","191-192"] 0.424 upd1___dome_scores_rank_005_alphafold2_multimer_v3_model_2_seed_000.json SET_69 59.204 0.44 413 1282
Average A / B upd1 dome 15 / 15 0.372 1793.06 759.44 0.413 0.932 0.506 0.259 0.535 190.8 / 257 20.2 / 21.2

Predicted Aligned Error Map

Rank 1

Click for full size

upd1dome
upd1___dome_pae.png

Protein A - FBgn0004956 /   upd1

Highlights Show Interactions

Protein B - FBgn0043903 / dome

Highlights Show Interactions

Linear Contact Map

Rank 1
Lines connect cLIR residue pairs within Cβ distance in the 3D structure. Per-rank structures fetched automatically.
Akt (A):PH (106–211)Protein kinase (266–523)AGC-kinase C-terminal (524–597)TED 1 (2.30.29.30) (108–218)TED 2 (3.30.200.20) (264–591)TED 3 (1.10.510.10) (351–544)UniProt: Q8INB9
foxo (B):Fork-head (95–201)TED 1 (1.10.10.10) (101–163)UniProt: A0A0B4KGN1

Circular Contact Map

Rank 1
Arcs represent chains (proportional to length). Lines connect cLIR residue pairs in physical contact.
Selected Rank
All Ranks Combined

3D Structure Viewer

Rank 1

Interactive 3D preview powered by Mol* (Sehnal et al. 2021). LIR regions shown as cartoons; cLIR residues highlighted. Drag to rotate, scroll to zoom.

Visualization Settings

Rank 1

Color Scheme

Chain A (Protein 1)

LIR - confident domain (PAE ≤ 12)

cLIR - confident interface (PAE ≤ 12 & Cβ ≤ 8 Å)

Chain B (Protein 2)

LIR - confident domain (PAE ≤ 12)

cLIR - confident interface (PAE ≤ 12 & Cβ ≤ 8 Å)

Presets - gradient (LIR light, cLIR dark)

Presets - high contrast (all 4 colors distinct)

Presets - solid

UniProt /Protein Details

Rank 1
Flybase ID Uniprot Symbol EBI Alphafold
FBgn0004956 Q9VWW4 upd1 https://www.alphafold.ebi.ac.uk/entry/Q9VWW4
FBgn0004956 O96525 upd1 https://www.alphafold.ebi.ac.uk/entry/O96525
FBgn0004956 Q8MZC7 upd1 https://www.alphafold.ebi.ac.uk/entry/Q8MZC7
FBgn0043903 Q9VWE0 dome https://www.alphafold.ebi.ac.uk/entry/Q9VWE0

Subcellular localization predictions

Rank 1
FBgn0004956 /   upd1:
FBgn0043903 /   dome:

Expression correlation

cell_line

'modENCODE_mRNA-Seq_cell.B'

Pearson Correlation: 0.09

tissues

modENCODE_mRNA-Seq_tissues

Pearson Correlation: 0.166

treatment

modENCODE_mRNA-Seq_treatments

Pearson Correlation: 0.558

development_stages

modENCODE_mRNA-Seq_U

Pearson Correlation: 0.85

cell_line

'modENCODE_mRNA-Seq_cell.B'

Pearson Correlation: 0.09

tissues

modENCODE_mRNA-Seq_tissues

Pearson Correlation: 0.166

treatment

modENCODE_mRNA-Seq_treatments

Pearson Correlation: 0.558

development_stages

modENCODE_mRNA-Seq_U

Pearson Correlation: 0.85


MIST Interaction Details

- Paper Counts Reference (PMID)
Protein-protein interaction (Fly) 3 10879541,11825879,26658615
Genetic interaction (Fly) 6 11696329,12403714,16277982,14668372,11825879,20072127
Protein-protein interaction (Interologs) 0 N/A
Genetic interaction (Interologs) 0 N/A