DRSC/TRiP Functional Genomics Resources

Public DRSC Screens

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Cell Line Library Total
Reagents
Screened		 View Hits Download Hits Raw Data Assay Type PubMed PubChem Paper Pub.
Year
Comparison of GPCR Induced vs. Small G-Protein Induced Signalling to the Nucleus
S2 Genome vs1, Genome vs2 17210 2335 2335 77568 rows Luminescence 23177739 (2009)
A Functional Insulator Screen Identifies NURF and dREAM Components to Be Required for Enhancer-Blocking.
S2 Genome vs2, TF 23390 0 0 29568 rows Fluorescence 25247414 PDF 2014
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.
S2R+ Genome vs1 22534 1644 1644 97260 rows Fluorescence, Imaging 17086199 PDF 2006
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.
S2R+ Genome vs1 21306 153 153 21061 rows Imaging 16511445 PDF 2006
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.
Kc Genome vs1 22534 18 18 37661 rows Luminescence 17517653 504808 PDF 2007
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.
S2R+ Genome vs1 22914 476 476 48384 rows Luminescence 19942856 504716 PDF 2010
A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.
DL2 Genome vs1 22914 20 20 356 rows Fluorescence 18042462 504807 PDF 2007
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion.
S2R+ Genome vs2 23328 0 0 61440 rows Luminescence 21886182 PDF 2011
A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila
S2 Genome vs1 22914 1199 1199 56448 rows Luminescence 22432040 PDF 2012
A genome-wide RNAi screen reveals multiple regulators of caspase activation.
Kc Genome vs1 21306 47 47 39948 rows Luminescence 17998402 504804 PDF 2007
A Genome-Wide Screen Identifies Genes That Affect Somatic Homolog Pairing in Drosophila.
SL2 Genome vs1 22534 17 17 789 rows Imaging PDF 2012
A genome-wide, high-throughput cell-based RNAi screen for factors
S2 Genome vs2 23328 0 0 54528 rows Luminescence (2009)
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.
SL2 Genome vs1 22914 126 126 647 rows Imaging 20100940 504771 PDF 2010
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.
S2R+ KP 1361 0 0 0 rows Imaging 20585561 PDF 2010
A Screen for Morphological Complexity Identifies Evolutionary Conserved Regulators of Discrete Switch-like Morphogenesis
Unknown KP 1361 33 33 2488 rows Imaging 652248 (2013)
A systems-level interrogation identifies regulators of Drosophila blood cell number and survival.
Kc Genome vs1, MK 22535 470 470 85630 rows Luminescence 25749252 PDF (2009)
Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen.
S2R+ Genome vs2 23309 0 0 126336 rows Fluorescence PDF 2012
Basic-Leucine Zipper Protein Cnc-C is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome.
S2 TF 1803 0 0 0 rows Fluorescence 21149573 PDF 2010
BCL9 Screen
S2L4 Genome vs2 22718 76 76 48384 rows Luminescence (2012)
Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6.
Unknown Genome vs1 15606 17 17 331 rows Luminescence 19572019 504772 PDF 2009
Biochemical and functional characterization of Orai proteins.
S2R+ Genome vs1 21091 24 24 24 rows Imaging 17293345 504802 PDF 2007
Cell Cycle-dependent Mechanism Controlling Centromere
Kc Genome vs1 22534 6 6 983 rows Imaging (2009)
Comparative Analysis of Argonaute-Dependent Small RNA Pathways in Drosophila,
S2 Genome vs1, Genome vs2 28868 199 199 75352 rows Luminescence 19026789 504791 PDF 2008
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.
S2R+ Genome vs1 21306 2646 2646 2664 rows Imaging 21893601 PDF 2011
Complete understanding of Toll signaling pathway in Drosophila
Unknown Genome vs2 24063 1089 1089 50688 rows Luminescence (2012)
Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses.
Kc Genome vs2, TF 23995 799 799 7202 rows Imaging PDF 2013
COPI activity coupled with fatty acid biosynthesis is required for viral replication.
SL2 Genome vs1 22534 111 111 309 rows Imaging 17040126 PDF 2006
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry.
S2 Genome vs1 22914 2069 2069 41611 rows Fluorescence 16645049, 23878724 PDF, PDF 2006
Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.
S3 TM 3504 258 258 13056 rows Fluorescence 29229844 (2017)
Definition of global and transcript-specific mRNA export pathways in metazoans.
S2R+ Genome vs1 22914 83 83 922 rows Imaging 18086857 504805 PDF 2008
Determine the host factors that induce expression of Salmonella virulence genes inside host cells
S2R+ Genome vs2 23328 0 0 38989 rows Imaging (2008)
Discovery of insect and human dengue virus host factors.
S2 Genome vs2 22632 520 520 47452 rows Imaging 19396146 504761 PDF 2009
Drosophila genome-wide RNAi screen identifies multiple regulators of HIF-dependent transcription in hypoxia.
S2 Genome vs1 21306 609 609 70944 rows Luminescence 20585616 504786 PDF 2010
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.
S2 Genome vs1 22914 82 82 143 rows Imaging 16020694 PDF 2005
DRSC Initial characterization of RNA Bind Protein library with total ATP levels assay
S2R+ RNA-binding 813 18 18 2640 rows Fluorescence, Luminescence (2015)
DRSC Total ATP levels assay of Megadeath library
S2R+ Megadeath 96 5 5 768 rows Luminescence (2017)
DRSC Total ATP levels assay of Membrane-bound organelle library1
S2R+ MB01 419 6 6 1536 rows Luminescence (2015)
DRSC Total ATP levels assay of Trans-membrane protein library
S2R+ TM 3504 195 195 16224 rows Luminescence (2015)
Dynamic Switch of Negative Feedback Regulation in Drosophila Akt-TOR Signaling.
Unknown Genome vs1 22534 1137 1137 94464 rows Fluorescence 20585550 504744 PDF 2010
ER retention of the cleaved EGFR ligand Spitz
S2R+ Genome vs1 13536 263 263 263 rows Imaging (2009)
Factors affecting human androgen receptor transcriptional activation
S2R+ Genome vs2, KP 22479 246 246 55294 rows Luminescence 23403032 652243 (2013)
Factors that Regulate the Recruitment of the Dosage Compensation Complex to the X Chromosome
Kc Genome vs2 22491 577 577 49026 rows Imaging (2011)
False negative rates in Drosophila cell-based RNAi screens: A case study.
S2R+ KP, NCRNA 1809 5 5 6912 rows Luminescence 21251254 504711 PDF 2011
Flockhouse Virus
Unknown Genome vs1, Genome vs2 17079 426 426 569 rows Imaging (2009)
Full-genome investigation of calcium uptake in Drosophila cells
S2R+ Genome vs2 23695 0 0 49536 rows Fluorescence (2010)
Functional genomic analysis of the Wnt-wingless signaling pathway.
clone 8 Genome vs1 22534 233 233 28709 rows Luminescence 15817814 652259 PDF 2005
Functional genomics reveals genes involved in protein secretion and Golgi organization.
S2 Genome vs1 22534 1068 1068 47650 rows Luminescence 16452979 686937 PDF 2006
Genes involved in store-operated calcium entry
S2 Genome vs1 22914 75 75 53762 rows Fluorescence 16751269 686938 (2013)
Genes regulating lipid storage in Drosophila melanogaster
Kc Genome vs1, Genome vs2 17210 736 736 37803 rows Imaging (2008)
Genetic Determinants of Phosphate Response in Drosophila
S2R+ Genome vs2 23328 143 143 56063 rows Fluorescence 23520455 PDF 2013
Genetic modifiers of cell survival following exposure to DNA damaging agents
Kc, S2 Genome vs1 22914 109 109 356832 rows Luminescence (2009)
Genome-wide RNAi analysis of growth and viability in Drosophila cells.
Kc, S2R+, SL2 Genome vs1 21306 429 429 84920 rows Luminescence 14764878 493246 PDF 2004
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.
S2* Genome vs1 22534 120 120 40738 rows Luminescence 16055650 PDF 2005
Genome-wide RNAi screen for genetic modifiers of Mitotane (o.p'-DDD) cytotoxicity in Drosophila Kc167 cells
Kc Genome vs2 22632 0 0 152448 rows Luminescence (2011)
Genome-wide RNAi screen for host factors required for intracellular bacterial infection.
SL2 Genome vs1 22534 311 311 23123 rows Imaging 16020693 504811 PDF 2005
Genome-wide RNAi Screen for Rb-synthetic Lethal Genes
S2* Genome vs1 22914 30 30 33 rows Luminescence (2009)
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
S2 Genome vs2 22632 723 723 50305 rows Fluorescence 19797662 504721 PDF 2009
Genome-wide screen for genes involved in microRNA biogenesis and siRNA activity
S2R+ Genome vs2 22502 0 0 49920 rows Fluorescence (2007)
Genome-wide TSC1 TSC2 and wildtype control screen project
BG2, S2R+ Genome vs2 21948 166 166 135936 rows Fluorescence (2017)
Hh Signalling
clone 8 Genome vs1 22534 503 503 43465 rows Luminescence 16311596 652272 (2003)
High Throughput Screen for the study of Sterol-accelerated degradation of HMG CoA reductase.
S2 TM, UB 4691 0 0 22272 rows Fluorescence (2012)
High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model.
Primary KP 1361 0 0 0 rows Imaging 21909362 PDF 2011
Homolog Pairing FISH analysis (TF Set)
Unknown TF 2082 4 4 0 rows Imaging (2011)
Host Factors Required for Modulation of Phagosome Biogenesis and Proliferation of Francisella tularensis within the Cytosol.
S2R+ Genome vs2 23325 467 467 52606 rows Fluorescence 20552012 504705 PDF 2010
Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation.
SL2 Genome vs1, Genome vs2 22520 322 322 360 rows Luminescence PDF 2012
Identification of co-factors and target genes required for FOXO-induced muscle atrophy in D. melanogaster
BG2 TF 1803 0 0 15944 rows Imaging (2011)
Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.
S2* Genome vs2 23328 0 0 58752 rows Luminescence 26643480 (2009)
Identification of genes involved in juvenile hormone signaling through genome-wide RNA interference screening in Drosophila cells
S2 Genome vs2, TF 1936 781 781 4200 rows Luminescence (2019)
Identification of genes required for HOW-dependent RNA degradation
S2R+ Genome vs1 15257 680 680 32640 rows Fluorescence (2009)
Identification of genes that impact the function of the GBP/Mthl10 signaling axis
S3 Genome vs2, RNA-binding 24381 234 234 0 rows Fluorescence (2018)
Identification of Genes That Promote or Antagonize Somatic Homolog Pairing Using a High-Throughput FISH-Based Screen.
BG2 Genome vs2 24063 111 111 0 rows Imaging PDF 2012
Identification of neural outgrowth genes using genome-wide RNAi.
Primary Genome vs1 22534 136 136 2632 rows Imaging 18604272 504795 PDF 2008
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.
S2R+ Genome vs1 21306 170 170 93142 rows Luminescence 18519643 504794 PDF 2008
Identification of novel nuclear actin regulating proteins
S2R+ Genome vs2 23328 26 26 49148 rows Imaging 26021350 (2009)
Identifying modulators for the mammalian nuclear hormone receptor RORgamma-t
S2 Genome vs2 22547 0 0 52608 rows Luminescence (2011)
Interactions between Legionella pneumophila and its host
Unknown Genome vs2 12464 617 617 12288 rows Fluorescence (2011)
Kc Cell Morphology
Kc Genome vs1 22534 226 226 369 rows Imaging (2009)
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
S2 Genome vs1 22914 134 134 0 rows Imaging 18662975 PDF 2008
Mn Toxicity Assay of DRSC Megadeath library
S2R+ Megadeath 96 6 6 768 rows Luminescence (2017)
Mn Toxicity Assay of DRSC membrane-bound organelle library1
S2R+ MB01 419 20 20 2304 rows Luminescence (2015)
Mn Toxicity Assay of DRSC Trans-membrane protein library
S2R+ TM 3504 154 154 21120 rows Luminescence (2015)
Modifiers of notch transcriptional activity identified by genome-wide RNAi
Kc Genome vs1 22534 684 684 22670 rows Luminescence 20959007 (2009)
Molecular circadian clock in Drosophila
S2 Genome vs1 22534 31 31 52224 rows Luminescence (2009)
Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads.
S2 Genome vs1 22534 2165 2165 0 rows Imaging 17785517 PDF 2007
Nuclear targeting factors of MAD-Follow Up
S2R+ Genome vs2 22491 0 0 24934 rows Imaging (2011)
p53
S2 Genome vs1 22914 785 785 248448 rows Luminescence (2009)
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.
Kc Genome vs1 21306 220 220 222 rows Imaging 15547975 PDF 2004
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.
Unknown KP, TF 3131 17 17 4943 rows Imaging 18927396 PDF 2008
Polycomb Staining
S2 Genome vs2, TF 23759 174 174 38571 rows Imaging (2014)
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.
Kc Genome vs2 22491 1509 1509 95237 rows Fluorescence 22028469 PDF 2011
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling.
S2R+ Genome vs1 22534 1671 1671 95232 rows Fluorescence, Imaging 22028469 PDF 2011
Regulators of Autophagosome Formation in Drosophila Muscles.
Primary Autophagy, KP 1872 189 189 3456 rows Imaging 25692684 PDF (2015)
Regulators of X-chromosome dosage compensation
SL2 Genome vs1 22534 79 79 306 rows Imaging (2009)
RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance.
Primary Genome vs1, Genome vs2 22534 50 50 1049 rows Imaging 18359903 504798 PDF 2008
RNAI screen for genes required for processing of Cubitus interruptus (Ci)
Kc Genome vs2 22632 291 291 48768 rows Luminescence (2012)
RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection.
S2 Genome vs1 15609 160 160 489 rows Imaging 17967059 PDF 2007
RNAi Screen to Identify Kinases and/or Phosphatases Whose Knock-Down is Synthetic Lethal With Activated Ras in S2 cells
S2 KP 1361 0 0 8832 rows Luminescence (2012)
Screen for novel regulators of G2/M checkpoint
S2 Genome vs2, KP 23068 115 115 23807 rows Imaging 504793 (2011)
Screen to identify genes that regulate Rho signaling during cytokinesis
Kc Genome vs2 23328 54 54 0 rows Imaging (2008)
Synthetic lethal TSC screen with FDA library
S2R+, Tsc1, Tsc2 FDA 63 63 0 rows Luminescence (2017)
Synthetic-lethal interactions with oncogenic Ras
S2 Genome vs2 22491 0 0 95229 rows Luminescence (2011)
The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.
Kc Genome vs2 24063 404 404 50648 rows Imaging 27514026 1159615 (2011)
The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells
S2R+ Genome vs1 22534 27 27 789 rows Imaging (2008)
The ROS Regulatory Network
BG2 Genome vs2, KP, TF, UB 24241 0 0 139 rows Imaging (2009)
Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis.
S2 Genome vs1 22914 369 369 718 rows Imaging 18984163 PDF 2008
Unveiling the mechanisms that suppress replication of an arthropod baculovirus in Drosophila
S2R+ Genome vs2 22632 0 0 60705 rows Imaging (2012)
viability with autophagy library
S2R+ unknown 211 0 0 1152 rows Fluorescence (2010)
VSV Screen
SL2 Genome vs1 22534 552 552 674 rows Imaging (2009)
Zn Toxicity Assay of DRSC Autophagy library
S2R+ Autophagy 575 23 23 3312 rows Luminescence (2015)
Zn Toxicity Assay of DRSC Megadeath library
S2R+ Megadeath 96 6 6 1152 rows Luminescence (2017)
Zn Toxicity Assay of DRSC membrane bound organelle library1
S2R+ MB01 419 14 14 1536 rows Luminescence (2015)
Zn Toxicity Assay of DRSC Trans-membrane protein library
S2R+ TM 3688 95 95 21888 rows Luminescence (2015)


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