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Signed protein-protein interaction network (Signed PPI) was developed at Harvard Medical School, in the lab of Norbert Perrimon and Drosophila RNAi Screening Center (DRSC). Signed PPI is a database of protein-protein interaction networks. The current version of the Signed PPI database contains Drosophila signed PPI network, i.e. PPI network with predicted edge-signs (activation/inhibition relationships). The resource includes both literature based signs (collected from SignaLink, KEGG and STKE databases) and predicted edge-signs. The purpose of the database is to help researchers to access, build and navigate signed protein-protein interaction networks by offering a simple and interactive web interface.
If you use Signed PPI in your research, please cite our paper:
Arunachalam Vinayagam, Jonathan Zirin, Charles Roesel, Yanhui Hu, Bahar Yilmazel, Anastasia A Samsonova, Ralph A Neumuller, Stephanie E. Mohr, and Norbert Perrimon.
Integrating protein-protein interaction networks with phenotypes reveals signs of interactions
Nature Methods (2013) doi:10.1038/nmeth.2733
PMID: 24240319