Sequence


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PTM  Sites

Number of Observed Sites: 21

Pos AA PTM Source(s) Confidence
366 S Phosphorylation Perrimon 1
370 S Phosphorylation Perrimon 1
392 T Phosphorylation Perrimon 1
394 S Phosphorylation Perrimon 1
418 T Phosphorylation Gygi 1
432 S Phosphorylation Gygi, Perrimon, SwissProt 3
438 T Phosphorylation Gygi, Perrimon, SwissProt 3
450 T Phosphorylation Perrimon 1
453 T Phosphorylation Perrimon 1
466 T Phosphorylation Gygi, Mann, SwissProt 3
468 S Phosphorylation Gygi, Mann, Perrimon, SwissProt 4
477 T Phosphorylation Mann 1
519 T Phosphorylation Perrimon 1
709 S Phosphorylation Aebersold, Gygi, Mann 3
731 S Phosphorylation Gygi 1
810 T Phosphorylation Gygi, SwissProt 2
827 S Phosphorylation Gygi, SwissProt 2
829 M Oxidation Gygi 1
833 S Phosphorylation Gygi, Perrimon, SwissProt 3
834 S Phosphorylation Gygi, SwissProt 2
838 S Phosphorylation Gygi, Perrimon, SwissProt 3

Number of Aligned* Residues: 31

Pos AA PTM Score? Details
337 D N/A 0
366 S Phosphorylation 1.0p
368 N N/A 0
370 S Phosphorylation 1.0p
388 K N/A 0
392 T Phosphorylation 1.0p
394 S Phosphorylation 1.0p
405 P N/A 0
416 H N/A 0
418 T Phosphorylation 0.83
432 S Phosphorylation 1.0p
437 S Phosphorylation 0.24
438 T Phosphorylation 1.0p
444 T Phosphorylation 0.19
450 T Phosphorylation 1.0p
453 T Phosphorylation 1.0p
465 R N/A 0
468 S Phosphorylation 1.0p
519 T Phosphorylation 1.0p
551 T Phosphorylation 0.18
613 S Phosphorylation 0.82
687 T Phosphorylation 0.26
696 G N/A 0
794 L N/A 0
800 A N/A 0
801 E N/A 0
810 T Phosphorylation 0.67
833 S Phosphorylation 1.0p
834 S Phosphorylation 0.35
838 S Phosphorylation 1.0p
865 T Phosphorylation 0.15
*Residues aligned to at least one experimentally determined phosphosite across six Drosophila species.

Domains

Region Domain Description External Link
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Subcellular  Localizations

Nucleus. Chromosome. Note=Binds to polytene chromosomes from salivary glands. Localized at late-replicating intercalary heterochromatin and pericentric heterochromatin. Colocalizes with many Polycomb Group proteins binding sites on polytene chromosomes.

Kinase  Target  Predictions

These predictions are based on 70 selected mammalian kinase motifs from Scansite 3's web service. Their online tool is currently on version 4. To see the best predicted D. mel ortholog, click on .

Gene Motif Motif Group Sequence Region Score
PRKAA1  -   AMP Kinase (AMPK) Basophilic serine/threonine kinase group (Baso_ST_kin) SGLGKVATVAALLSA 55..69 0.5097
PLK1  -   PLK1 Kinase (PLK1) Acidophilic serine/threonine kinase group (Acid_ST_kin) RGHSLNNSFCTSMLL 145..159 0.2558
PIP3-E  -   PIP3-binding PH (PIP3_PH) Lipid binding group (Lip_bind) LSEYIKDFRLRRFRH 231..245 0.5946
CDC2  -   Cdc2 Kinase (Cdc2_Kin) Proline-dependent serine/threonine kinase group (Pro_ST_kin) EIVTPPSTPQNRTPS 352..366 0.4095
CDK5  -   Cdk5 Kinase (Cdk5_Kin) Proline-dependent serine/threonine kinase group (Pro_ST_kin) EIVTPPSTPQNRTPS 352..366 0.377
CDK1  -   CDK1 motif 2 - [ST]PxxK (CDK1_2) Proline-dependent serine/threonine kinase group (Pro_ST_kin) RTPSLNESPRTKSKK 363..377 0.2915
PRKCZ  -   PKC zeta (PKC_zeta) Basophilic serine/threonine kinase group (Baso_ST_kin) KKKFSKKTSPRKKAD 376..390 0.4009
PRKCA  -   PKC alpha/beta/gamma (PKC_common) Basophilic serine/threonine kinase group (Baso_ST_kin) KKFSKKTSPRKKADL 377..391 0.294
PRKCZ  -   PKC zeta (PKC_zeta) Basophilic serine/threonine kinase group (Baso_ST_kin) KKFSKKTSPRKKADL 377..391 0.4167
CDC2  -   Cdc2 Kinase (Cdc2_Kin) Proline-dependent serine/threonine kinase group (Pro_ST_kin) KKFSKKTSPRKKADL 377..391 0.3638
CDK5  -   Cdk5 Kinase (Cdk5_Kin) Proline-dependent serine/threonine kinase group (Pro_ST_kin) KKFSKKTSPRKKADL 377..391 0.2979
CDK1  -   CDK1 motif 1 - [ST]Px[KR]x (CDK1_1) Proline-dependent serine/threonine kinase group (Pro_ST_kin) KKFSKKTSPRKKADL 377..391 0.2155
CDK1  -   CDK1 motif 2 - [ST]PxxK (CDK1_2) Proline-dependent serine/threonine kinase group (Pro_ST_kin) KKFSKKTSPRKKADL 377..391 0.2278
AKT1  -   Akt Kinase (Akt_Kin) Basophilic serine/threonine kinase group (Baso_ST_kin) RKRTRAATVHLTPKT 407..421 0.3823
MAPK1  -   Erk D-domain (ErkDD) Kinase binding site group (Kin_bind) KRTRAATVHLTPKTR 408..422 0.4363
CDK5  -   Cdk5 Kinase (Cdk5_Kin) Proline-dependent serine/threonine kinase group (Pro_ST_kin) RAATVHLTPKTRRLN 411..425 0.3705
CAMK2G  -   Calmodulin dependent Kinase 2 (Cam_Kin2) Basophilic serine/threonine kinase group (Baso_ST_kin) GQEKKQKTVDVPAQG 536..550 0.2761
PRKACG  -   Protein Kinase A (PKA_Kin) Basophilic serine/threonine kinase group (Baso_ST_kin) TITQRRRTLLEDDFF 803..817 0.1869
PIK3R1  -   p85 SH3 mode1 (p85_SH3_m1) Src homology 3 group (SH3) LASLRKSPKSPKQGA 880..894 0.4935
CDK5  -   Cdk5 Kinase (Cdk5_Kin) Proline-dependent serine/threonine kinase group (Pro_ST_kin) SLRKSPKSPKQGAKS 882..896 0.3707