Protein Alignment NUP93 and npp106

DIOPT Version :10

• Sequence 1: NP_055484.3
• Gene: NUP93 / 9688
• HGNCID: 28958
• Length: 819
• Species: Homo sapiens
• Sequence 2: NP_588422.1
• Gene: npp106 / 2539077
• PomBaseID: SPCC1739.14
• Length: 933
• Species: Schizosaccharomyces pombe
• Alignment Length: 938
• Identity: 209/938 - (22%)
• Similarity: 371/938 - (39%)
• Gaps: 194/938 - (20%)

Human     6 FGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRT-LTRTSQETADVKASVLLGSRGL 69
            ||.||:            .::|.::..|.::::....|.|:. |||    ..|.||..||...|:
pombe    36 FGVLLE------------PQVPVIQYGLNQLEEKARNLESKVLLTR----DGDTKAHYLLAESGM 84

Human    70 DISHISQRLESLSAATTFEPLE-PVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESM 133
            :.....|::.|:...:.::.|| ..|....|...|......::::||...:..   ..|:....|
pombe    85 NAEQTRQKIYSIHIHSPWDQLELDKKSLYEQPHTKLYNGQNVVASIENGYQSN---VYEFQLRLM 146

Human   134 L---VEWEQVKQ-------RILHTLLASGEDALDFTQESEPSY-----------------ISDVG 171
            .   :.||..|.       ::||:...||. ....:....|:.                 :.:||
pombe   147 KNNGIAWENTKTEFMEDVGKLLHSKDNSGL-GTSISMSLRPNLARPLLTASSVKSQSVRSLREVG 210

Human   172 -----PPG-----------------RSSLDNI------EMAYARQIYIYNEKIVNGHLQPNLVDL 208
                 |.|                 ||...||      ..::|..::..||..:... ..::..|
pombe   211 SNLPIPTGSLTKIDGLNNQLSNDLTRSQTTNIFGFAEKASSFAAAVHKLNEARIRNQ-ACHVWSL 274

Human   209 CASVAELDDKSI---SDMWTMVKQMTDVLLTPATD------ALKNRS-SVEVRMEFVRQALAYLE 263
            .|||:::.:..:   .|.|:::..|.|.......|      ||.:.| ::.|....:..:|.|||
pombe   275 FASVSQMVNTEVIQLFDAWSLLAHMIDETRYGMGDFEARHLALDSSSAALAVEKNCIEGSLKYLE 339

Human   264 QSYKNYTLVTVFGNLHQAQLGGVPG--------TYQLVRSFLN---IKLPAPLPGLQDGEVEGHP 317
            ..:  .:|:    :||.:..|.:..        .|..:|.:.|   ||....:       |...|
pombe   340 NQF--LSLI----DLHLSDAGHITTVNSVEKVIAYSKLRFYKNGSWIKSTVSV-------VNDVP 391

Human   318 VWALIYYCMRCGDLLAASQVVNRAQ---HQLG-EFKTWFQEYMNSKDRRLSPATENKLRLHYRRA 378
            :|.:::|.||.|.|.||.|.||...   .:|| .|..:|..|..:....|.....::|:..|.:.
pombe   392 LWVVLFYLMRSGQLDAALQFVNTYSDDFEKLGRSFPLYFYSYAKNPSLPLPKQLRDRLQAEYGQL 456

Human   379 LR-NNTDPYKRAVYCIIGRCDV-TDNQSEVADKTEDYLWLKL-------NQVCFDDDGTSSPQDR 434
            :: ...||:|.|:|.::|.|:. ..:..||...:|||:|::|       |.| .|.:|..|....
pombe   457 MKYAPEDPFKHAIYKLLGNCEPHRVSLPEVCVTSEDYMWIQLMFCRVNQNDV-IDSNGGQSTNSL 520

Human   435 LTLSQFQKQLLEDYGESHFT-VNQQPFLYFQVLFLTAQFEAAVAFL---FRMERLRCHAVHVALV 495
            ..|.|.:|:::. :|..:|. .|..|..||..|.:..:||.|::||   :.:|     |.|.|:.
pombe   521 FNLYQLEKKIVA-FGPRYFNPKNNTPTNYFLALLMCGEFERAISFLHTNYPVE-----ATHFAVA 579

Human   496 LFELKLL-LKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKD 559
            :....|| .|:..::..:|.:|..|.    ::||.:|::.|.:..|..|....|.|...:.....
pombe   580 MAYYGLLRTKNYEKNENILIYEADDV----KINFPQLIIAYLKHLEYVDAAVYLDYIACIPLVPA 640

Human   560 SQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVID------KFTSDT-KPIINKVASVAE 617
            .|..::.|..:  |:::|.||...||.::.|..|..|::|      .|..|: :.:..:.|..|:
pombe   641 YQACSINLTKI--LLLQSHEFSKFLGDIKPDTERTTGLLDLYLRLIPFDHDSLQKLYLEGAREAD 703

Human   618 NKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALS--IAERYRAQGIS 680
            :.|.|.::..||.|..:.|.|:.:..|.||..:........:.:..|||.:|  :........::
pombe   704 DDGRFGDSIILYHLLGDYDTVIGVAIKNLSQSIVSRGLWSIDSKESKNMHISSNVVASEAPDALA 768

Human   681 ANKF------------VDST----FYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPLNQESVE- 728
            ||..            |.:|    ..:||.::.....|.....|....:||.|.|:|:|:...|
pombe   769 ANLLAMYESNPKKSAKVSATNKKALKVLLKVVKVQKLYGQEKWDEVLQLIEHLDLLPINEVQAEF 833

Human   729 --------------ERVAAFRNFSDEIRH---NLSEVLLATMNILFTQFKRLKGTSPSSSSRPQR 776
                          .|...|..|.||:..   :|..:.::::..|:....:|...:..|..:.||
pombe   834 EPNEQIPPISARLRRRAFEFSTFQDEVLSVIPSLMYISMSSIKALYRTISKLPVVNEESKKKLQR 898

Human   777 VIEDRDSQLRSQARTLITFAGMIPYRTS 804
                    |:.:...|:.|:.||..|.|
pombe   899 --------LQFKGSMLVMFSTMIESRLS 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP93	NP_055484.3	Nic96	218..810	CDD:461172	158/669 (24%)
npp106	NP_588422.1	Nic96	288..924	CDD:461172	158/665 (24%)