Protein Alignment NUP93 and npp-13

DIOPT Version :10

• Sequence 1: NP_055484.3
• Gene: NUP93 / 9688
• HGNCID: 28958
• Length: 819
• Species: Homo sapiens
• Sequence 2: NP_740802.1
• Gene: npp-13 / 171774
• WormBaseID: WBGene00003799
• Length: 787
• Species: Caenorhabditis elegans
• Alignment Length: 856
• Identity: 221/856 - (25%)
• Similarity: 384/856 - (44%)
• Gaps: 125/856 - (14%)

Human     1 MDTEGFGELLQ----QAEQLAAE-TEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKA 60
            :|.:||.:||.    |..::..| ::..:....||:.|..|....|...:|       :|..|:.
 Worm    11 VDHQGFAQLLANPIFQTNRVGQENSQQFTVRNGVEQELCGILGGSEGDWTR-------QTHSVQK 68

Human    61 SVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMA 125
            .::.|.||:::.  |::.:|.:|..|.        || :|.:  :...|::..|:|
 Worm    69 QMMFGERGIELP--SRQPKSHTAEDTL--------TD-EGVV--DVPEAVMDDIDE--------- 111

Human   126 EEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYISDVGPPGRSSLDNIEMAYA---- 186
            ||...:...|:.|..:....|.||            |.|:.: .:.|......||:.....
 Worm   112 EELDEDISRVKVETDRAFFNHMLL------------SRPAAV-PMNPAQAMERDNLPFGGGKFVN 163

Human   187 -----RQIYIYNEKI---VNGHLQPNLVDLCASVAELD--DKSISDMWTMVKQMTDVLLTPATDA 241
                 |:..|:.:|:   :....:.:||||.....:..  |.::.|:|..|..    :|...|.|
 Worm   164 KNISDRRELIFGDKLHKFLKNQGKKSLVDLMKEAIDESGTDGALGDVWNDVTS----VLNRKTSA 224

Human   242 LKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPLP 306
              :|..:......|..|..||:..:..:....|..||..|:.||:|||..||.:||.:.......
 Worm   225 --SRDDLTTTANLVEDACKYLQAVFTEHMQTVVERNLEVAERGGIPGTRGLVNAFLKVGTEESFQ 287

Human   307 GLQDGEVEGHPVWALIYYCMRCGDLLAASQVVNRAQHQLGEFKTWFQ-----EYMN--SKDRRLS 364
            . :|..::|.|.|.:.|:|:|.||:.:||:.:||       .|::.|     ..:|  :|..:|.
 Worm   288 P-EDDSIDGMPTWQVTYHCVRAGDMKSASETLNR-------LKSFPQCATLVAALNHVAKHGKLD 344

Human   365 PATENKLRLHYRRALRNNTDPYKRAVY-CIIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGT 428
            ...:.||::.:|..|.:..|.||||:| .::|..|    .:.:||..|:::|.||..:..|...|
 Worm   345 SELKKKLKVEWRHNLAHTKDKYKRALYAALLGGLD----SAALADTLENWIWFKLYPLHVDPQLT 405

Human   429 SSPQDRLTLSQFQKQLLEDYGESHFTVN-QQPFLY-FQVLFLTAQFEAAVAFLFRMERLRCHAVH 491
            .     :...:.||.:..||||.:|..| ...|.| |..|:|:.|||.|:..|....: |..:||
 Worm   406 D-----VLFKEVQKAVSVDYGEQYFMSNGPSEFQYFFTALWLSGQFERAIYLLHECGQ-RVDSVH 464

Human   492 VALVLFELKLLLKSSGQSAQLLSHEPGD-PPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLR 555
            ||::..:|..|..|...:.::|..:..| ..|  .||..||::.||:.||..|...:|.|::.|:
 Worm   465 VAVLAHKLGYLRMSKKSTDEMLVVDQNDSTKC--HLNLARLIVAYTKSFELVDVPRSLDYWFLLK 527

Human   556 DEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKG 620
            ......|.::|...||..|..:.:.|.|||||..||.|:.|:||::..|...:|.:|||..|..|
 Worm   528 GITTPTGSDVFEMAVSRSVYLTGQTDEILGKLTPDGRREKGLIDEYLDDPSEVICRVASDTEITG 592

Human   621 LFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYR--AQGISANK 683
            .:::|..||.||........|::..:|..:     ...|||::.:: :.:||:::  .:|..|::
 Worm   593 EWDQAVGLYLLASKPTNAAILLSSEISETL-----RTENKEKIADL-VHVAEQFKKVQRGCQASE 651

Human   684 FVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPLNQESVEERVAAFRNFSDEIRHNLSEV 748
            :  :|..||:||...||...:...:.|:.|...|:|:|...:.|...|..|.....::|..|.::
 Worm   652 Y--ATLSLLVDLAVLFDHCRNEEAEIAYGISTHLRLIPTEPDQVTVIVNEFHMVPQKVREVLPDM 714

Human   749 LLATMNILF--------TQFKR-LKGTSPSSSSRPQRVIEDRDSQLRSQARTLITFAGMIPYRTS 804
            .|..|..|.        ||..| ....:.|..|...|.::        |.:.::.::..:||:..
 Worm   715 CLHLMKCLVDHCIRQSTTQANRGANSATTSMFSSSNRYVK--------QIKAIVLYSATVPYKFP 771

Human   805 GDTNARLVQME 815
            ....:||:|::
 Worm   772 THVTSRLLQLQ 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP93	NP_055484.3	Nic96	218..810	CDD:461172	170/613 (28%)
npp-13	NP_740802.1	Nic96	209..777	CDD:461172	170/609 (28%)