Protein Alignment SCARB2 and santa-maria

DIOPT Version :10

• Sequence 1: NP_005497.1
• Gene: SCARB2 / 950
• HGNCID: 1665
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_609121.2
• Gene: santa-maria / 34024
• FlyBaseID: FBgn0025697
• Length: 563
• Species: Drosophila melanogaster
• Alignment Length: 434
• Identity: 126/434 - (29%)
• Similarity: 223/434 - (51%)
• Gaps: 31/434 - (7%)

Human    34 DQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGET-PRVEEVGPYTYRELRNK 97
            |..:.|::.|...|..:::|:.||:.:....|.:|.||||:.....| |.:|:||||.:.|..:|
  Fly    42 DWIMHKEMALAPDTRVYENWKSPPIDLSLDIYLYNWTNPEDFGNLSTKPILEQVGPYRFIERPDK 106

Human    98 ANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVL----TVIEWSQVHFLREIIEA 158
            .:|.:.....:::......:.|:...|.|... |.|.|||...|    |...|..|.  |.:::.
  Fly   107 VDIHWHPENASVTYRRRSLFYFDAAGSNGSLD-DEITTLNAVALSAAATAKYWPPVK--RSLVDV 168

Human   159 MLKAYQQKLFVTHTVDELLW-GYKDEILSL---IHVFRPDIS-PY--FGLFYEKNGTND--GDYV 214
            .||.|..::.|..::||||: ||.|.::.:   :.:|..::. |:  ||.||.:||:.|  |.:.
  Fly   169 GLKMYGAEMSVQKSIDELLFTGYNDAMIDVAMAMPIFGDEVKVPFDKFGWFYTRNGSADLTGVFN 233

Human   215 FLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPLITK-DEVLYVFPSDFCRSVY 278
            ..||.|......::..||.:.:..:: ...|.|.||:.|: |.|...| .:.:.:|..|.||::.
  Fly   234 VFTGADQLAKLGQMHSWNYQENTGFF-DSYCGMTNGSAGE-FQPQHLKPGDSVGLFTPDMCRTIP 296

Human   279 ITFSDYESVQGLPAFRYK-VPAEILANTSDNAGFCIPEGNCLGSGVLNVSICKNGAPIIMSFPHF 342
            :.:.:...::||..:::. .|..:...|......|...|.|:.|||:|:|.|:.|:|:.||:|||
  Fly   297 LDYVETVDIEGLEGYKFSGGPRSVDNGTQYPENLCFCGGQCVPSGVMNISSCRFGSPVFMSYPHF 361

Human   343 YQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFP 407
            :.||..:...:||:.|||:|||.::.:.|.|||.|:.|.|||:|:.|:.:........|..:.||
  Fly   362 FNADPYYPDQVEGLSPNQKDHEFYMVVQPSTGIPLEVAARFQVNMLVEPIQGISLYTGIPRIFFP 426

Human   408 VMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMALGVFFGL 451
            :::..:.|.|..:.|.:||.          :|.::::..:|.|:
  Fly   427 LVWFEQKVRITPDMADQLKV----------LPIVMLSGHIFAGI 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCARB2	NP_005497.1	CD36	28..457	CDD:460076	126/434 (29%)
		Important for interaction with GBA1	155..191		11/39 (28%)
santa-maria	NP_609121.2	CD36	21..476	CDD:460076	126/434 (29%)