Protein Alignment COG7 and cog7

DIOPT Version :8

• Sequence 1: NP_705831.1
• Gene: COG7 / 91949
• HGNCID: 18622
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_001070861.1
• Gene: cog7 / 768247
• ZFINID: ZDB-GENE-061013-463
• Length: 767
• Species: Danio rerio
• Alignment Length: 770
• Identity: 543/771 (70%)
• Similarity: 652/771 (85%)
• Gaps: 3/771 (0%)

Human     1 MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKLQLFIQEVNHAVEETSHQALQN 65
            ||||||||||||||:|:|.||:...|: |.||||.||:||||||||||||||:::||:|:|||||
Zfish     1 MDFSKFLADDFDVKDWVNGAFKVAQKD-APGKADAHASTLVMKLQLFIQEVNNSIEESSNQALQN 64

Human    66 MPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESLQEADK 130
            ||:||||:|||||||||||:||||||||||||||||.|||||||||||||||||||||:||||||
Zfish    65 MPRVLRDIEALKQEASFLKDQMILVKEDIKKFEQDTVQSMQVLVEIDQVKSRMQLAAEALQEADK 129

Human   131 WSTLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAA 195
            ||||||||||||||||:||||:|||.||.||.|||||||||||||.|||||||||||.|.|||:.
Zfish   130 WSTLSADIEETFKTQDVAVISSKLTAMQGSLAMLVDTPDYSEKCVQLEALKNRLEALTSTQIVST 194

Human   196 FTSQAVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDLSLDRQLTGLYDALLGA 260
            |.|.|.||:|:||:||||:|||||||||||||||.|||..|:.:||||..|.:||:..||.||..
Zfish   195 FNSLATDQAKLFVRVFTEMDRMPQLLAYYYKCHKAQLLTVWESICQSDAPLKQQLSEFYDTLLST 259

Human   261 WHTQIQWATQVFQKPHEVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQELTRLLEFYDATAHFA 325
            ||||:||::|||:.|.||:.||:||||||::||:|.|::..::|...:..|..|||.:..:|:|:
Zfish   260 WHTQLQWSSQVFRNPCEVLTVLMIQTLGAMVPSIPDCIAETLKRCSGDCRLDVLLELHQTSANFS 324

Human   326 KGLEMALLPHLHEHNLVKVTELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQE 390
            :.||.|:.|.|.|.||:||.|||..||.|||.||::||.:||:|||||:||||||.|||:|||.|
Zfish   325 RSLEAAMQPQLGECNLLKVAELVSCVYSPYKTYQIQYGGLEETNLLIQLSAVPLERGEVLDCVLE 389

Human   391 LSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLDHIPPN 455
            |:|||.|:||||:|||||||:||:||..|||:.||::||.||||||:.||||||||.||:..|.:
Zfish   390 LTHSVQKVFGLAAAAVDRCVKFTDGLAVCGLIKALRALFNKYVSDFSVTLQSIRKKYKLEDTPTS 454

Human   456 SLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPRSLAGFQESILTD 520
            .:|.|||||||||:|:|||||||||.||.|||||:|:||..||::|.:..:||||.|.||.:.
Zfish   455 EVFTEDWTAFQNSVRVIATCGELLRQCGAFEQQLSNKILGRAGRFLWEGFNPRSLTGLQEGVA-- 517

Human   521 KKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAAPRAALTRLNQQAHQLAFDS 585
            ::.|.|||||||||||:.|.|||.:|:|.|::|||||:.|.:|||..|||||||||||:||||||
Zfish   518 ERRSQKNPWQEYNYLQQSNTAEYNNLLETLHSLKEKGTGNSSLLAETRAALTRLNQQANQLAFDS 582

Human   586 VFLRIKQQLLLISKMDSWNTAGIGETLTDELPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDS 650
            |||:|||||.|::|.::..:|.:||||||:||||||:|.|||:|||||||||||:|||||||||.
Zfish   583 VFLQIKQQLFLLNKPEARGSASLGETLTDDLPAFSLSPQEYITNIGQYIMSLPLHLEPFVTQEDP 647

Human   651 ALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDAILQIPELSPHSAKQLATDI 715
            |||||||.||||:||||||::|||:|.||.|||||||||||||||.|||:||||.|..|||||||
Zfish   648 ALELALHTGKLPYPPEQGDDVPELENTADYWLGSIARATMQTYCDVILQLPELSAHHTKQLATDI 712

Human   716 DYLINVMDALGLQPSRTLQHIVTLLKTRPEDYRQVSKGLPRRLATTVATMRSVNY 770
            |||.|||||||||.|||||:|||||:.:|::|||.:|.|||||:.|:|.:|.:.|
Zfish   713 DYLSNVMDALGLQTSRTLQNIVTLLRVKPDEYRQTAKTLPRRLSATIANIRGLEY 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COG7	NP_705831.1	COG7	2..767	CDD:287200	541/765 (71%)
cog7	NP_001070861.1	COG7	2..764	CDD:287200	541/765 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C311982284
eggNOG	1	0.900				E1_KOG4182
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H33431
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D198192at33208
OrthoFinder	1	1.000				FOG0007671
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_131606
Panther	1	1.100			LDO	PTHR21443
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
ZFIN	1	1.500
	11	11.220