Protein Alignment SLC6A5 and CG4476

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_648293.1
• Gene: CG4476 / 39056
• FlyBaseID: FBgn0035969
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 219/629 (35%)
• Similarity: 343/629 (55%)
• Gaps: 63/629 (10%)

Human   168 SVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIP 232
            ::|..|:..:|.:..|...:.|||.||.|.|:|::|.:..:||||||||||:.|.:|||||||||
  Fly    28 ALLKPSLLPMALESSELSPDRKARDNWGSSLEFLMSCIALSVGLGNVWRFPFTALENGGGAFLIP 92

Human   233 YLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFY 297
            ||::|.:.|.||:::|:.||||:|:|.|.|:...|.::|.|.|.|:...::|.||..::..||.|
  Fly    93 YLVVLFVVGKPIYYMEMLLGQFSSRGIVQVFDFAPLMRGVGYAQLLALGVLATYYASVMALTLRY 157

Human   298 LFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCV-ISDHPKIQIKNSTFCMTAYPNVTMVNFTS 361
            .|.||.|.|||..|...|.            |.|| .|....:|                    .
  Fly   158 FFDSFASELPWSFCREEWG------------DGCVSASGGQPLQ--------------------G 190

Human   362 QANKTFVSGSEEYFKYFVL----KISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVV 422
            |.::.|.|.::.|.:..||    .:..||.||.   ..|||.|.::|:.|...:.:|:|:|||..
  Fly   191 QLSRNFSSSTQLYLQRIVLNETDSLEEGIGYPS---GSLALMLGISWLTVTLIIIRGVKSSGKAA 252

Human   423 YFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLIT 487
            |..|.|||||:.|||:|.:|||||..|:.||:||:||||.:..||.:|.||:||||:..:|.:|.
  Fly   253 YVLALFPYVVMFILLVRALTLPGAYDGVMYFLTPQWEKLLEPQVWYNAVTQVFFSLAVCFGVIIM 317

Human   488 LSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVADQGPGIAFVVYP 551
            .||||:|.:|.|||..|||..::.||:.:|.:||.::|.:|:|... :|.:|...|||:||:.||
  Fly   318 YSSYNRFGHNVYRDANIVTTLDTFTSLLSGVIIFGILGNLAHESGTKDIASVVKAGPGLAFISYP 382

Human   552 EALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFI 615
            :|:.:..:.| .::::||.||..||:.:....:..|:|.:.|:|   :.....:..:...:..|:
  Fly   383 DAIAKFKMFPQVFSLLFFAMLFMLGVGSNVGMVSCIMTVLKDQF---VNVKLWIIVVSLSVIGFL 444

Human   616 MGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVC 680
            :|...||.||.::..|:|.:..::..::.|||||:.:.::||.:|.|:|.|.|:..:.:.::::|
  Fly   445 VGLIYITPGGQHIITLMDFHGVTFVSLVSAIFELIAVGWIYGTKRLCQDAEYMLNIKTSNYYRIC 509

Human   681 WAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSV----IWIPIMFVIKMHLAP 741
            |:.|||.::..||.:|.....|::|....:|....|:||.:..|.:    .|..   ........
  Fly   510 WSIVTPLVMLVILVYSLLTMRPLSYNGQEFPLVYRVVGWCVSGCIIGQLFYWAG---YANFKQPK 571

Human   742 GRFIERLKLVCSPQPDWGP-----------FLAQHRGERYKNM 773
            |....|:.....|..||||           ||.....|..||:
  Fly   572 GSLKSRINNSIKPHSDWGPSDPKKLMDYQMFLRNKDEENSKNV 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	213/606 (35%)
CG4476	NP_648293.1	SLC6sbd	52..526	CDD:271359	192/512 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C107584597
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840