Protein Alignment SLC6A5 and CG8850

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 630
• Identity: 222/631 (35%)
• Similarity: 344/631 (55%)
• Gaps: 53/631 (8%)

Human   164 DGITSVLPGSVATVATQEDEQGDENKA-RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGG 227
            |||::|:..:.....|...|...|:.. |..||..::|:.|.:..:||||||||||::|.:||||
  Fly    29 DGISTVIYSAEGEELTINCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGG 93

Human   228 AFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIIC 292
            ||||||:::|.|.|.|:::|||.:|||:|:|.:..:...|.::|.....:..:.|...||..|:.
  Fly    94 AFLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMA 158

Human   293 YTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMV 357
            .|:.||.|||..||||..|...|.            .|||.:                  ..|..
  Fly   159 LTIRYLVASFSEVLPWTYCLVEWG------------KSCVAT------------------GATAA 193

Human   358 NFTSQANKTFVSGSEEYFKYFVLKISAGIEYP--GEIRWPLALCLFLAWVIVYASLAKGIKTSGK 420
            |.:|....  ||.:|.:|...||:....::..  |...|.|.|||...|||:...|:|||::|||
  Fly   194 NDSSIVQG--VSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGK 256

Human   421 VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGL 485
            ..||.|.||||::::||||.||||||..||.||:.|:|.:|.:..||..|.||:||||:..:|.|
  Fly   257 ASYFLALFPYVIMIVLLIRAVTLPGAWQGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTL 321

Human   486 ITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKV-NIENVADQGPGIAFVV 549
            :..:|:|.|:.|.::|.:|:|..:|.|||.||.:||.::|.:|.|... :|..|...|.|:||:.
  Fly   322 VMYASFNDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFIS 386

Human   550 YPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKP--VFTLGCCI 611
            ||||:.:....| .:|::||.|||.||:.:.......:|..:.|.|     ||.|  :..:...|
  Fly   387 YPEAIAKFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRF-----THLPHWLLAVSASI 446

Human   612 CFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIF 676
            ..|:.|...:|.||.::..|||.|..::..:::||.||:.:.::||::|.|.|||.|:..:.:.:
  Fly   447 IGFLCGLVYMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFY 511

Human   677 WKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAP 741
            |::|||.|.|.::..:|.:..:.:||:||...:||....:.||::....|:.:|...::.::..|
  Fly   512 WRICWAIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQP 576

Human   742 GR-FIERLKLVCSPQPDWGPFLAQ-------HRGERYKNMIDPLG 778
            |: |..:..|...|..:|||...|       || :|..:...|.|
  Fly   577 GKTFGSKFGLAMQPTANWGPLQTQKFEAYIIHR-KREADFKSPRG 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	215/603 (36%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	190/511 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C107584638
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840