Protein Alignment SLC6A5 and CG1698

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001260835.1
• Gene: CG1698 / 36006
• FlyBaseID: FBgn0033443
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 668
• Identity: 236/669 (35%)
• Similarity: 360/669 (54%)
• Gaps: 91/669 (14%)

Human   113 GPGNALHCKIPFLRGPEGDANVSVGKGTLER--NNTPVVGWVNMSQSTVVLGTDGITSVLPGSVA 175
            |..||....||....|...:|   ||.||..  .:.|..|..:.                |..|
  Fly    21 GSLNASTISIPGAYKPNESSN---GKKTLSEGSGSAPPPGHGDS----------------PSGV- 65

Human   176 TVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
                   |.|...|.|.:|::.::|::|.:..:||||||||||:.|.:||||||:||||::|.|.
  Fly    66 -------EAGQPGKKRDSWNNDIEFLMSCIALSVGLGNVWRFPFTALENGGGAFVIPYLIVLILV 123

Human   241 GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSV 305
            |.|:::||:.||||:|:|.|.|:...|.::|.|...::.:.::..||..::..||.|...||...
  Fly   124 GKPVYYLEMLLGQFSSRGSVKVYDFSPIMRGIGYGQVLATGIVTTYYATLMALTLRYFVDSFYPT 188

Human   306 LPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370
            |||..|...|.| ||       |||     .|:                      ..:..|.::|
  Fly   189 LPWSYCREEWGT-EC-------LDS-----GPQ----------------------EASRATSLAG 218

Human   371 S-------EEYFKYFVLK----ISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYF 424
            |       |.||...:|:    |..||.||.   |.|||.|.:||:::...:.||:|:|||..||
  Fly   219 SGVRTTSAEFYFTNIILREKASIDDGIGYPS---WSLALALAVAWIVIAGIMFKGVKSSGKASYF 280

Human   425 TATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLS 489
            .|.|||||:::||:|.:|||||..|:.||:.|:|.||.:..||..|.||:||||:..:|.:|..:
  Fly   281 LALFPYVVMLVLLVRALTLPGAFDGVLYFLRPQWHKLLEPQVWYAAVTQVFFSLAICFGNIIMYA 345

Human   490 SYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERK-VNIENVADQGPGIAFVVYPEA 553
            |||:|.:|.|||..|||..::.||:.:|.:||.::|.:|.|.. .:|.:|.:.|||:||:.||:|
  Fly   346 SYNRFGHNIYRDANIVTTLDTFTSLLSGVIIFGILGNLAYENNTTDIASVVNGGPGLAFISYPDA 410

Human   554 LTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMG 617
            :.:....| .::::|||||..||:.:.......:.|.|.|:| .:|:....|  :|..|..:.:|
  Fly   411 IAKFKWLPQLFSVLFFLMLFVLGIGSNVGMASCMSTVIKDQF-GHLKNWTVV--VGIAIVGYFLG 472

Human   618 FPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWA 682
            ...||.||.::..|||.:..::..:::||||||.|:::||::|.|.|:|.|||.:.::::::|||
  Fly   473 LLYITPGGQFLLNLVDYFGVTFVALVLAIFELVTIAWIYGVKRLCRDVEFMIGIKTSLYYRICWA 537

Human   683 FVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSV----IW-IPIMFVIKMHLAPG 742
            .|||.::..||.::...:||:.|..|.|.:...|.||.:.|..|    .| ||.:.....||.
  Fly   538 VVTPLLMLTILIYTLVLYEPLKYKDYTYQSGVYVFGWCLSAFGVGQVLFWAIPAVRKQPSHLG-- 600

Human   743 RFIERLKLVCSPQPDWGP 760
             ...|::....|.|:|||
  Fly   601 -LWARIRKAFEPLPNWGP 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	218/589 (37%)
CG1698	NP_001260835.1	SLC6sbd	75..552	CDD:271359	196/518 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C107584555
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840