Protein Alignment SLC6A5 and CG15279

DIOPT Version :10

• Sequence 1: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_609726.1
• Gene: CG15279 / 34863
• FlyBaseID: FBgn0028886
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 659
• Identity: 232/659 - (35%)
• Similarity: 367/659 - (55%)
• Gaps: 60/659 - (9%)

Human   140 TLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKA------RGNWSSKL 198
            |.:||:          |:...:..||.::.....::|.:....:..|:.:|      |..|...:
  Fly     3 TTQRNH----------QNLAFVGDDGRSTASTVEISTNSPALRDNSDDQEAAKVPEERATWGKGV 57

Human   199 DFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVW 263
            :|::|.:..:||||||||||:.|..|||||||||||::|.|.|.||::||:.:|||:|:|.|.|:
  Fly    58 EFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKPIYYLEMVIGQFSSRGSVKVF 122

Human   264 KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPW------NTPECKD 322
            ...||::|.|........:::.||..::.....|...||.:.|||.:|...|      :.|:..:
  Fly   123 DLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPWSTCRAEWGIHCINSAPDASN 187

Human   323 KTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVL----KIS 383
            .::|      .|:..:.|            |.||    ...|...::.||.||...||    .|.
  Fly   188 WSQL------ESNDQRPQ------------NYTM----KSQNDRVITSSEWYFVKEVLHEKPNIE 230

Human   384 AGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGA 448
            .||..|   .|.|.:.||:||..|:..:.:|:|:|||..||.|.||||::.:||:|.|||||:..
  Fly   231 EGIGLP---NWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSID 292

Human   449 GIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATS 513
            ||:|||.|:|.|:.|..||..|.||.|:|||..:|.:|..||:|||.:|.:||..|||..::.||
  Fly   293 GIYYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTS 357

Human   514 IFAGFVIFSVIGFMANERKV-NIENVADQGPGIAFVVYPEALTRLP-LSPFWAIIFFLMLLTLGL 576
            :.|||.||.::|.:|:|... :|.:|...|.|:||:.||:|:.:.. |...::::|||||..||:
  Fly   358 LLAGFTIFGILGHLAHEIGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGI 422

Human   577 DTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYAL 641
            .:..|.....||:|.|.||.:.:..   .:|...:..|.:|...||.||.||..|||.:.||...
  Fly   423 GSNIAMTSCSVTAIRDRFPNFGQWQ---CSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMIA 484

Human   642 VIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYG 706
            :::.|.||..|.::||..|.|:|||.|:|.:..::|::||:.:||.|:|.||.:.:..::|:||.
  Fly   485 LVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPLTYN 549

Human   707 SYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFI-ERLKLVCSPQPDWG---PFLAQHRG 767
            :..|||||..:|||:.|..::.:||..::.:...||:.: .:::...:|:.:||   |.|.:...
  Fly   550 NIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPKKNWGPSDPLLREQYH 614

Human   768 ERYKNMIDP 776
            :..:|.:.|
  Fly   615 KEIENELTP 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	223/602 (37%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:444915	216/575 (38%)