Protein Alignment SLC6A5 and CG13796

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001137807.1
• Gene: CG13796 / 34051
• FlyBaseID: FBgn0031939
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 158/628 (25%)
• Similarity: 256/628 (41%)
• Gaps: 136/628 (22%)

Human   188 NKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQ--------NGGG-AFLIPYLMMLALAGLP 243
            :|.||.|:...||..:...:|        |..|.|.        :||. .|:|.|||.:....||
  Fly    81 DKCRGRWAKSADFYFASCTHA--------FSSLIFSELSTFGILHGGWLLFIIAYLMGMLFYSLP 137

Human   244 IFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPW 308
            ||.::..||||:|.|.:|.::..|..:|.|.|:|::::....||::.....|.|...|...|:||
  Fly   138 IFLIQAFLGQFSSSGTISAFRVAPIFKGIGYAILLLNLGTLTYYSIAAVVPLIYTVNSIHPVIPW 202

Human   309 GSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEE 373
            .||||.|||.||.......:|...:..|..::...|....||..:.:|
  Fly   203 MSCNNSWNTQECSLHENYDVDDYRVDPHSTVEFFRSMIASTAKGSTSM----------------- 250

Human   374 YFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVV---------YFTATFP 429
                             .|.|.:.:.:...|::|.|.|.|.:...|||:         :|.|.|.
  Fly   251 -----------------SISWSMLIGVLSIWLVVLALLLKPVAFIGKVLRCSCVLMFGFFVAVFL 298

Human   430 YVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFF---SLSAAWGGLITLSSY 491
            |    :|:...||..    .:.|:..|:.:...  ::...|.|.:..   :|...||.:||||||
  Fly   299 Y----LLIHEQVTFD----TLHYYWMPQLDSFD--SILATARTALLMAGGALGPGWGSIITLSSY 353

Human   492 NKFHNNCYRDTLIVTCTNSATSIFAGFVIFSV--------IGFMA--NERKVNIENVADQGPGIA 546
            |.|..:..|.::.| |....|....|.:..:|        :|.|.  .:.|.:::        ..
  Fly   354 NNFRRDAERLSIWV-CLTHITIGLMGLLCCNVAHDHFEDHVGMMPLHVDEKHHMQ--------FL 409

Human   547 FVVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHK------PV 604
            ::.:.....|...:| .||.:||.|:....|..:...:.:::|::.||| :.||:.:      .|
  Fly   410 YLCFSYLFGRFTTTPNLWAFLFFGMIFLSELCALIIQMMSVITALFDEF-ETLRSRRILVISSLV 473

Human   605 FTLGCCICFFI--MGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEM 667
            |.|.....:|.  :||..:||        :...|....|:|..|..|: .::|||..||..|::.
  Fly   474 FCLTASSVYFCTQLGFSQLTQ--------LPNLAVFTHLLISGILVLM-TTWVYGRVRFQCDLQF 529

Human   668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYR--------YPNWSMVLGWLMLAC 724
            |:|...:.|......|.||..|.  ||  .:|   :||...|        |.:..::   |:.|.
  Fly   530 MLGKTISSFKIFFIRFATPIFLG--LC--LFQ---LTYLFTRDRIHDVLIYVSQGLI---LLTAI 584

Human   725 SVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHR 766
            |.:      |.|:....|.:.:||:...:|. ||.|..|.:|
  Fly   585 SYM------VYKVCRTNGDWRQRLQQCLAPH-DWHPVDADNR 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	157/625 (25%)
CG13796	NP_001137807.1	SLC5-6-like_sbd	123..610	CDD:294310	141/567 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C103639448
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940