Protein Alignment SLC6A5 and CG13795

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001285712.1
• Gene: CG13795 / 34049
• FlyBaseID: FBgn0031937
• Length: 594
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 156/610 (26%)
• Similarity: 274/610 (45%)
• Gaps: 74/610 (12%)

Human   191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFA 255
            ||.|....||:.:..|.|:.| :|:...:..|.:.|...::||.:.:::..:||..:...:|||:
  Fly    20 RGKWDKPTDFMFACFGLALKL-DVFVASFWMFFDMGILGILPYFVYMSIYLVPIMVIHSFMGQFS 83

Human   256 SQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCN--NPWN-- 316
            |.|.:|.::..|..:|.|.....:::.:.|||::.....|.::..||...||| ||.  :.|:
  Fly    84 SSGFISAFRLSPFFKGMGYVSGFLTISMLIYYSIFAAVPLLFIINSFRPTLPW-SCEGLSSWHNG 147

Human   317 ----TPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKY 377
                :..| :||.:|.|   .|::      |.:..:...|:|  :.|.:..:........:::|.
  Fly   148 SATLSSSC-NKTLILED---FSEY------NRSHQLLHVPSV--LYFQNHYDSMQQDAVPDWYKD 200

Human   378 FVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTS--GKVVYFTATFPYVVLVILLIRG 440
            :            |:.|.......:.||::.....|..:|:  ||::.:......|:|::..:|.
  Fly   201 Y------------ELSWHFVGLFAIIWVVIAFIFYKFSETAKFGKLIRYMVIVTLVLLLVCFVRF 253

Human   441 VTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIV 505
            :.||||..|:..::|||...:....|  .....:..:..|.||.:|||||:|.|..:....:.|:
  Fly   254 LFLPGALNGLHRYVTPKASDMAMGVV--STFIMVLHAFGAGWGSVITLSSFNGFKTDIMSYSWII 316

Human   506 TCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIA-FVVY---PEALTRLPLSPFWAII 566
                |...||. :::|.::.||.......:.:|.|.|..:: :::|   ..||:.:.....|..|
  Fly   317 ----SFGQIFI-YIMFGMVSFMLEHYFNELSDVDDNGHVLSHWLLYLSSASALSTMAWPNLWTFI 376

Human   567 FFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQL 631
            ::.|||...|..|...|.|::.|:.||| :.||..|...|.|......:..|...|..||..|.
  Fly   377 YYSMLLIAALIVMTTQIFTVLQSLFDEF-EVLRVRKQEVTFGLIGGIALCSFYFCTNHGIIFFS- 439

Human   632 VDTYAASYALVIIAIFE--------LVGISYVYGLQRFCEDIEMMIGFQPNIFWKV-CWAFVTPT 687
                    ||.:.|||.        |:.:.::||.:||..|||.|:| ||...||| ...|:.|.
  Fly   440 --------ALGLDAIFSHSLLHLLLLLVVLWIYGRERFQRDIEFMLG-QPFASWKVFILRFIAPI 495

Human   688 ILTFILCFSFYQWEPMTYGSYRYPNWSM-VLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLV 751
            ||...|....    .::...:.|....: |:..:::...::.||......::.:.|.|.||.|..
  Fly   496 ILVICLLAGI----ALSISEHSYSTTVVFVMSIVLVVLPILAIPGYGFYYLYQSTGTFCERFKRT 556

Human   752 CSPQPDWGPFLAQHRGERYKNMID 775
            |.| .||.|...:|| ::|:..:|
  Fly   557 CRP-TDWYPVEMEHR-QQYEEAVD 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	156/610 (26%)
CG13795	NP_001285712.1	SLC5-6-like_sbd	27..505	CDD:271356	135/522 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C103639294
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930