Protein Alignment SLC6A5 and CG13793

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_609136.2
• Gene: CG13793 / 34047
• FlyBaseID: FBgn0031935
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 610
• Identity: 156/611 (26%)
• Similarity: 265/611 (43%)
• Gaps: 81/611 (13%)

Human   191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFA 255
            ||||....|:|.:..|.|:.| :::...:..|.|.|...::||||.:.:..:||..:...:|||:
  Fly    12 RGNWEKPTDYIFACFGLALKL-DIFVASFWFFFNTGIFGMVPYLMYMVIYLVPIMVIHSYMGQFS 75

Human   256 SQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCN--NPWNTP 318
            |.|.:|.::..|..:|.|...|.:::.:.|||.:.....|.::..||...||| ||.  ..|...
  Fly    76 SSGFISAFRLSPLFKGMGYVSLFLTITLLIYYTIFAAVPLLFVLNSFRPTLPW-SCEGFKSWQND 139

Human   319 ECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSE--EYFKYFVLK 381
            ..   .|..:.:..|::....:.:|.|:......:|..|.:.....::|.:.||  :|
  Fly   140 TI---AKWSICNATIAEEVAKETENDTYFYITNIHVPSVLYFKSHFESFQNDSELNDY------- 194

Human   382 ISAGIEYPGEIRWPLALCLFLAWVIV------YASLAKGIKTSGKVVYFTATFPYVVLVILLIRG 440
                     ||.|.|:....|.|..:      ::..||    .||.:.:.......:|::..:|.
  Fly   195 ---------EISWHLSGLFALVWATIAFIFYKFSEPAK----FGKCIRYMVIGTVALLLVCFVRF 246

Human   441 VTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFF--SLSAAWGGLITLSSYNKFHNNCYRDTL 503
            :.||||..|:..::||..|:....|    ::|.|..  :..|.||.:|||||:|.|..|....:.
  Fly   247 LFLPGAHLGLKNYMTPSIEEFVVGT----SSTFIMALQAFGAGWGSVITLSSFNGFKTNIMSYSW 307

Human   504 IVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQ----GPGIAFVVYPEALTRLPLSPFWA 564
            |:    |...||. :::|.::.||.....:.:.....:    ...:.|:....||:.|.....|.
  Fly   308 II----SFGQIFI-YIMFGMVSFMLEHYFLGLPKPLFETQVINHWVLFLSSASALSSLGWPNLWT 367

Human   565 IIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLG------CCICFFIMGFPMITQ 623
            .|::.|||...|..:...|.||:.|:.||| :.||..|...|||      .|..:|      .|.
  Fly   368 FIYYTMLLMAALIVITTQIFTILQSLFDEF-EQLRAKKQEVTLGLIGGLAVCSLYF------CTN 425

Human   624 GGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKV-CWAFVTPT 687
            .|:..|.:: :..|.::..::.:..|:.:.:|||..||.:||:.|:| ||...||| ...||.|.
  Fly   426 HGVLYFAIL-SIDAIFSQTLLHLLLLLVVLWVYGRDRFQKDIKFMLG-QPFASWKVFILRFVAPP 488

Human   688 ILTFILCFSFYQWEPMTYGSYRYPNWSMVLGW---LMLACSVIWIPIMFVIKMHLAPGRFIERLK 749
            .|...|....    .|....:.|.  |.||.:   :::...::.||......:|..||...|..:
  Fly   489 TLVICLVLEI----KMCLEEHSYS--SSVLHFMAIILVGLPILAIPAYGFYYIHQRPGSISELFR 547

Human   750 LVCSPQPDWGPFLAQHRGERYKNMI 774
            ..     ||.|...::| ::|..::
  Fly   548 AT-----DWYPVEMEYR-QQYGELV 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	156/611 (26%)
CG13793	NP_609136.2	SLC5-6-like_sbd	19..498	CDD:271356	136/522 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C103639367
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930