Protein Alignment SLC6A5 and Ntl

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_609135.1
• Gene: Ntl / 34046
• FlyBaseID: FBgn0267326
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 236/594 (40%)
• Similarity: 367/594 (62%)
• Gaps: 34/594 (6%)

Human   176 TVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240
            |.||::|::.:.::.||.|.||.:||||::|||:|:|||||||||.:::||.|||||||:|:.||
  Fly     9 TNATRKDKRIERDENRGQWKSKSEFILSLLGYAIGIGNVWRFPYLCYRSGGAAFLIPYLLMVILA 73

Human   241 GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSV 305
            |:|:|::|:.:|||:|.|...:::..|.|:|.|||.::::.....||:|||.|.:..:|..|...
  Fly    74 GIPLFYMEILIGQFSSTGCTGMFRMTPLLKGTGIAQVVVNAYCVCYYSVIISYPIRMIFYCFFKK 138

Human   306 LPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSG 370
            :||..|:|.|||.:|          ...||..|   :||                   :..|.:.
  Fly   139 VPWEDCSNSWNTDDC----------VTASDMGK---QNS-------------------SDVFKTS 171

Human   371 SEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVI 435
            ::|:|...||:||..|...|.:.|.....|.:.|:|:|..|.:|||:.|||||||..|||::|.|
  Fly   172 ADEFFHLEVLRISTDISDLGGMVWEQLTALIITWIIIYFCLMRGIKSVGKVVYFTVPFPYLLLFI 236

Human   436 LLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYR 500
            |||||.|||||..||.:::.|:|.:|.|..||.|||.|:||.:...|||::.::|::.|.||...
  Fly   237 LLIRGATLPGAWKGIKFYLYPEWHRLLDLKVWADAAVQMFFGIGPGWGGIVNMASFSSFRNNAKC 301

Human   501 DTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAI 565
            |::::...|..||:.||||:|||:||::.:..:.:|:||..|.|:|||.||||:..||:...||:
  Fly   302 DSVLIVSINVFTSLLAGFVVFSVLGFLSEKSGIPVESVATGGAGLAFVTYPEAIALLPVPQLWAL 366

Human   566 IFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQ 630
            :||.||..||:|::|..:|.|::||.||: .::|:||...||..|:.|..:...|.|.||:::.|
  Fly   367 MFFFMLFLLGIDSVFVQLEAIMSSILDEW-YWVRSHKCKLTLISCLIFLGLSSIMCTNGGMFILQ 430

Human   631 LVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCF 695
            |.|.|:::.|:::|.:.|::.::::||::.|..|:|.|:|.:|.::|::.|..|||.|:.|||..
  Fly   431 LFDWYSSAIAVIVICLVEIIMVAWIYGIKNFMLDVEFMLGKRPTLYWRIVWQVVTPVIIIFILIT 495

Human   696 SFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGP 760
            |......:||.:..||.|::::||.....||:|||:.....|........:.||....|. ||.|
  Fly   496 SIVFIRTITYNNIPYPQWAIIIGWASCFTSVMWIPLYIFYIMIRKRATLCDSLKKRLKPL-DWTP 559

Human   761 FLAQHRGE 768
            ...|.|.|
  Fly   560 ADPQDRAE 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	232/579 (40%)
Ntl	NP_609135.1	SLC5-6-like_sbd	24..554	CDD:294310	225/563 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_128673
Panther	1	1.100			LDO	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.900