Protein Alignment SLC6A5 and ine

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 865
• Identity: 285/866 (33%)
• Similarity: 435/866 (50%)
• Gaps: 151/866 (17%)

Human    14 ANSPEAAAAQG---------HPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARA 69
            ||.|.||.:..         :.:|...|        .||:.|.|..:|..:.|.|       ...
  Fly   129 ANQPTAAVSTSTVTFTIDDCNEEGDAIP--------AAASVPAPVTMPAISPTPA-------TLT 178

Human    70 CEAERPGVGSCKLSSP-------RAQAASAALRDL--------------------REAQGAQASP 107
            |.......|.....||       |..:..:::|.:                    ....|.||..
  Fly   179 CTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVGGVSMATSGLQAPN 243

Human   108 P---------PGSSG-----PGNALHCKIPFLRGPEGDANVSVG-----KGTLERNNTPVVGWVN 153
            |         .|||.     .||.::..:..:|..   |::.:|     |..:.|..|......:
  Fly   244 PLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSL---ASIGIGSTDGRKLVIRRVPTTANELFD 305

Human   154 M--SQSTVVLGTDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWR 216
            |  .|:...||.|...|.|..|        ||.......:.:|::|:.|:|:.:||:||||||||
  Fly   306 MVNPQTPPPLGVDDDDSYLDMS--------DETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWR 362

Human   217 FPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPV-SVWKAIPALQGCGIAMLIIS 280
            |||:.:::|||.||:||.::|.:..:|:.|:|:|:||:..:||: ::.:..|..:|.|:|.:::|
  Fly   363 FPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVS 427

Human   281 VLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNST 345
            .|::.||:|||.|:::|.|.||.:.:||..|||.||||:|
  Fly   428 FLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDC------------------------- 467

Human   346 FCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYAS 410
                ..|....:|  :.|..|..:.|||:|:..||:||.|:||||.:||.|..||..||::||.:
  Fly   468 ----WVPQRKGIN--ASAPDTSRTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFA 526

Human   411 LAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIF 475
            ..|.||:|.||.|||||||:|:::||::|.|||.||..|:.:|..|||.:|.:|.||.:||:|.|
  Fly   527 TWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAASQNF 591

Human   476 FSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD 540
            .||...:|.:|:.:||||::||..|||:.|:..|..||:..|...||.:|.:|.|:..|:.:|..
  Fly   592 NSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIG 656

Human   541 QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTH---K 602
            .|||:.|||||:|:.::|.:..||::||.|||.|||::.||.:|.:||||.|.||::::.|   .
  Fly   657 DGPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYH 721

Human   603 PVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEM 667
            .:..|..|:...:.|.|.|.|||||.|||:|.||||..::.:|..:::.|::.||..|..::::.
  Fly   722 EIVVLFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQ 786

Human   668 MIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTY--GSYRYPNWSMVLGWLMLACSVIWIP 730
            |.|..|:.:.:.||..:.|.:|..|...|...:...||  |.|.||:|:..:||:..:.|:|.||
  Fly   787 MTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIP 851

Human   731 IMFVIKMHLAPG-RFIERLKLVCSPQ----------------PDWGPF-LAQHRGERYKNMIDPL 777
            ...||....:.| .|.||::....|.                |:...| |||.....||.....|
  Fly   852 GYAVINFLRSSGDTFWERIRNTLRPNIYECKICGEHHCEHDYPEQEQFMLAQEMATVYKPTNPHL 916

Human   778 GTSSLGLKLPVKDLELGTQC 797
                         |.||.:|
  Fly   917 -------------LNLGQKC 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	236/620 (38%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	227/570 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C103639515
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840