Protein Alignment SLC6A5 and CG10804

DIOPT Version :8

• Sequence 1: NP_004202.3
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_001138150.1
• Gene: CG10804 / 31317
• FlyBaseID: FBgn0029663
• Length: 726
• Species: Drosophila melanogaster
• Alignment Length: 732
• Identity: 261/733 (36%)
• Similarity: 380/733 (52%)
• Gaps: 149/733 (20%)

Human    96 DLREAQGAQASPPPG-SSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVN------ 153
            :|||.:|...|...| |.....:||                         :.|:.|..|
  Fly    28 ELRELRGRLVSKEHGVSHHHHTSLH-------------------------HQPLYGATNQGFMSD 67

Human   154 -------MSQSTVVLGTDGITSVLPGSVATVATQEDEQGD------ENKARGNWSSKLDFILSMV 205
                   :.|.....|::..||.....:..:||...:|.|      |.:.|.:|.||:.|:|:.:
  Fly    68 AFDESSELEQDPPPFGSEASTSKAKAELVAIATASADQQDIVEGEKEGEERESWDSKIMFLLATI 132

Human   206 GYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PAL 269
            ||||||||||||||||.:|||||||:||.:||.:.|:|||:||:::||...:|.:.||..: |.|
  Fly   133 GYAVGLGNVWRFPYLAQKNGGGAFLVPYFIMLCIQGIPIFYLELAIGQRLRKGAIGVWSQVSPYL 197

Human   270 QGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIS 334
            .|.||:..::|.::|:|||.||.:.|.||..||.|.|||..|
  Fly   198 GGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLPWADC----------------------- 239

Human   335 DHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYF--VLKISAGIEYPGEIRWPLA 397
                             |.....|||.......|:.|...|.::  .|:.|..::.|....:.:|
  Fly   240 -----------------PTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMPENFNYHMA 287

Human   398 LCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLT 462
            :.|.::|.:||..:.:||.:|||:||.||.||||||:|...||:||.||..|:.:..||:||.|.
  Fly   288 IALIVSWFLVYICMVQGITSSGKIVYMTAIFPYVVLIIFFFRGITLKGAADGVAHLFTPRWETLL 352

Human   463 DATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFM 527
            |..||.:|.|||||||..|:||||..||||..:||||||.::|:.||..||:|||.|:||||||.
  Fly   353 DPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPANNNCYRDAILVSLTNCGTSMFAGVVVFSVIGFK 417

Human   528 AN---------------ERKVNIENVAD---------QGPGIAFVVYPEALTRLPLSPFWAIIFF 568
            |.               :.|.:...|.|         .|.|:||:::.||:.:.|.:..||::||
  Fly   418 ATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTGLAFIIFTEAINQFPGAQLWAVLFF 482

Human   569 LMLLTLGLDTMFATIETIVTSISDE--FPKYLRTH-KPVFTLGCC---ICFFIMGFPMITQGGIY 627
            |||.|||:|:.|.|:|.:|||:.|.  ||...:.: .......||   :||       ....|.|
  Fly   483 LMLFTLGIDSQFGTLEGVVTSLVDMKLFPNLPKEYIVGALCFSCCTISMCF-------ANGAGSY 540

Human   628 MFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFI 692
            :|||:|::|.::.|:|||:||.:.|||:||::||.:|||||.|.:||.:|..||.:::|..:..|
  Fly   541 IFQLMDSFAGNFPLLIIALFECLSISYIYGVRRFSDDIEMMTGSRPNFYWMFCWKYLSPCAMVTI 605

Human   693 LCFSFYQWEPMTYGS--------------YRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGR 743
            |..||||.  :|.||              ..:|:|.:|:.:.::..|::||||:.|:::.
  Fly   606 LLASFYQL--LTEGSSYPAWIGSKGATEGMEWPHWCIVVAFFLILSSILWIPIVAVLRLC----- 663

Human   744 FIERLKLVCSPQPDWGP 760
               .:|:|....|.|.|
  Fly   664 ---GIKVVEDSDPAWFP 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A5	NP_004202.3	SLC6sbd_GlyT2	191..787	CDD:271389	240/618 (39%)
CG10804	NP_001138150.1	SLC6sbd-B0AT-like	120..661	CDD:271364	234/590 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900