DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDKL2 and PKD

DIOPT Version :9

Sequence 1:	NP_001317653.1	Gene:	CDKL2 / 8999	HGNCID:	1782	Length:	570	Species:	Homo sapiens
Sequence 2:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	105/435 - (24%)
Similarity:	174/435 - (40%)	Gaps:	121/435 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     2 EKYENLG---------LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKM---VKKIAM--REI 52
            |:.:::|         ::|.|.:|:|....:|.|.|.||||..     ||:   .|:.|.  .|:
  Fly   532 EQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVI-----DKLRFPTKQEAQLKNEV 591

Human    53 KLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLF-QIINGIGF 116
            .:|:.:.|..:|||..:.:..:|.::|.|.:...:|:.:.....|...:.|.|:|. ||:..:.:
  Fly   592 AILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKY 656

Human   117 CHSHNIIHRDIKPENILVSQSG---VVKLCDFGFARTLAAPGE--VYTDYVATRWYRAPELLVGD 176
            .||.||:|.|:||||:|:|...   .|||||||:||.:   ||  .....|.|..|.|||:| .:
  Fly   657 LHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARII---GEKSFRRSVVGTPAYLAPEVL-RN 717

Human   177 VKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDI-DQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
            ..|.:::|:|::|.::.....|...|..:.|| ||:.:...           ::..||
  Fly   718 KGYNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQIQNAAF-----------MYPPNP------- 764

Human   241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQ 305
                        :.::|...|||....|.:...||....:.|.|.:.|            ..:..
  Fly   765 ------------WKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQ------------DKQTY 805

Human   306 KDARNVSLSKKSQNRKKEKEKDD----------------SLVEERKTLVVQDTNADPKIKDYKLF 354
            :|.||:. ::....|....|.||                :::|....|:  ..:|:...:.|
  Fly   806 RDLRNLE-AQVGAGRYLTHEADDLRWDCAGDMXPGCEPEAILESTTELI--SCSANTTTESY--- 864

Human   355 KIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSN 399
                            |.|.|.|....|           |.||.|
  Fly   865 ----------------RRSPADCAGCHR-----------LSDCGN 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDKL2	NP_001317653.1	STKc_CDKL2_3	2..287	CDD:270836	84/305 (28%)
		S_TKc	4..287	CDD:214567	83/303 (27%)
		[NKR]KIAxRE	45..51		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		5/20 (25%)
PKD	NP_001262705.1	C1_1	109..154	CDD:278556
		C1	223..272	CDD:197519
		PH_PKD	396..522	CDD:269945
		STKc_PKD	539..798	CDD:270984	82/297 (28%)
		S_TKc	547..799	CDD:214567	82/290 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910