Protein Alignment CDKL2 and Cdk5

DIOPT Version :10

• Sequence 1: XP_047272338.1
• Gene: CDKL2 / 8999
• HGNCID: 1782
• Length: 582
• Species: Homo sapiens
• Sequence 2: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Alignment Length: 288
• Identity: 107/288 - (37%)
• Similarity: 166/288 - (57%)
• Gaps: 3/288 - (1%)

Human     1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVN 65
            |:||:.:..:|||:||.|.|.||:||..|||:|:....:||:.|...|:|||.|||:|:|:|:|.
  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65

Human    66 LLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPE 130
            |::|....|:..||||..|..:....:.....:|..|.:.::.|::.|:.||||||::|||:||:
  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQ 130

Human   131 NILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEM 195
            |:|::::|.:||.|||.||....|.:.|:..|.|.|||.|::|.|...|..::|:|:.||::.|:
  Fly   131 NLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL 195

Human   196 F-MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEV 259
            . .|.|||||...:|||..|...||.  |........:.:...|.||.........:..|:|:..
  Fly   196 ADAGRPLFPGSDVLDQLMKIFRVLGT--PNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSK 258

Human   260 VIDLAKKCLHIDPDKRPFCAELLHHDFF 287
            ..||.:|.|...|::|......:.|.:|
  Fly   259 GRDLLQKLLICRPNQRISAEAAMQHPYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL2	XP_047272338.1	STKc_CDKL2_3	2..287	CDD:270836	105/285 (37%)
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	105/284 (37%)