Protein Alignment CDKL2 and IKKepsilon

DIOPT Version :9

• Sequence 1: NP_001317653.1
• Gene: CDKL2 / 8999
• HGNCID: 1782
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 637
• Identity: 143/637 - (22%)
• Similarity: 241/637 - (37%)
• Gaps: 133/637 - (20%)

Human     9 LVGEGSYGMVMKCRNKDTGRIVAIKKF-----LESDDDKMVKKIAMREIKLLKQLRHENLVNLL- 67
            ::|:|:.|.|.:..||.||..||:|.|     :...|      :.|||.:.||::.|||:|.||
  Fly    17 VLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPAD------VQMREFEALKKVNHENIVKLLA 75

Human    68 -EVCKKKKRWYLVFEFVD----HTILDDLELFPN--GLDYQVVQKYLFQIINGIGFCHSHNIIHR 125
             |..::.:...:|.|...    ..||||.|   |  ||........|..:..|:.....:.::||
  Fly    76 IEEDQEGRGKVIVMELCTGGSLFNILDDPE---NSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHR 137

Human   126 DIKPENIL--VSQSG--VVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKA---- 182
            |:||.||:  :|:.|  :.||.|||.||.| ...:.:.....|..|..|:|      |.:|
  Fly   138 DLKPGNIMKFISEDGQTIYKLTDFGAAREL-EDNQPFASLYGTEEYLHPDL------YERAVLRK 195

Human   183 ---------VDVWAIGCLVTEMFMGE-PL--FPGDSDIDQLYHIM------------------MC 217
                     ||:|:||..:..:..|. |.  |.|..:.:.::.|.                  :.
  Fly   196 SIQRSFTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQITTKKASGVISGTQLSENGPIE 260

Human   218 LGNLIPRHQELFN-----KNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF 277
            ....:|.|..|..     ..|:.||: |.|.:|:.....|:  ..||.:.|.|:.:|:....|..
  Fly   261 WSTTLPPHAHLSQGLKTLVTPLLAGL-LEENREKTWSFDRF--FHEVTLILRKRVIHVFFTNRTS 322

Human   278 CAELLHHDFFQMDGFAERFSQELQLKVQKDA---RNVSLSKKSQNRKKEKEKDDSLVEERKTLVV 339
            ..|:......|:|.|.||...:.::.::|..   .|..|.||...|...|....:..::...|..
  Fly   323 SVEVFLEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYS 387

Human   340 QDTN--ADPKIKDYKLFKIKGSKIDGEKAEKGNRASNA----SCLHDSR---------------- 382
            .|.|  ..|:..|...|.:....:..|     |.||.|    |..|:.:
  Fly   388 NDDNNVQLPQQLDLPKFPVFPPNVSVE-----NDASLAKSACSVGHECKRRVDIFTSMDILIKKG 447

Human   383 TSH--NKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEK 445
            ..|  ..:|.:.:|......|.|:..:..:....:.|:::.|.      .|.:.|         |
  Fly   448 VEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVT------KGDQEI---------K 497

Human   446 TKKCSIPFVKPNRHSPSGIYN-INVTTLVSSEKNLFWASK--------KRREYSRTDVRLPEL-- 499
            |...::..||.:....:.:.: ::...::..|.|..|.|.        |.|..::....:..|
  Fly   498 TLLTALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRD 562

Human   500 NYNHLPELRALGGIARNSRLTKKESKILSESRIPSLAAIDLHTPSITLHQVS 551
            ::.||...||...:..|........||..:.....:.|:.|...:.|:.|::
  Fly   563 SWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIA 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL2	NP_001317653.1	STKc_CDKL2_3	2..287	CDD:270836	87/333 (26%)
		S_TKc	4..287	CDD:214567	87/333 (26%)
		[NKR]KIAxRE	45..51		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..384		7/40 (18%)
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	79/296 (27%)
		STKc_TBK1	18..332	CDD:270890	87/332 (26%)
		UBL_TBK1_like	299..389	CDD:240618	21/91 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910