Protein Alignment CDKL2 and Cdk1

DIOPT Version :10

• Sequence 1: XP_047272338.1
• Gene: CDKL2 / 8999
• HGNCID: 1782
• Length: 582
• Species: Homo sapiens
• Sequence 2: NP_476797.1
• Gene: Cdk1 / 34411
• FlyBaseID: FBgn0004106
• Length: 297
• Species: Drosophila melanogaster
• Alignment Length: 304
• Identity: 121/304 - (39%)
• Similarity: 181/304 - (59%)
• Gaps: 26/304 - (8%)

Human     1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVN 65
            ||.:|.:..:|||:||:|.|.||:.||:|||:||.....||:.|...|:|||.|||:|:|||:|.
  Fly     1 MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVC 65

Human    66 LLEVCKKKKRWYLVFEFVDHTILDDLELFP--NGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIK 128
            |.:|..::.|.||:|||:...:...::..|  ..::.::|:.||:||.:.|.|||...::|||:|
  Fly    66 LEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLK 130

Human   129 PENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVT 193
            |:|:|:.:||::|:.|||..|:...|..:||..:.|.||||||:|:|..:|...||:|:|||:..
  Fly   131 PQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFA 195

Human   194 EMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP---VFAGV-RLPEIKEREP------ 248
            ||...:|||.|||:||||:.:...|            |.|   ::.|| .||:.|...|
  Fly   196 EMATRKPLFQGDSEIDQLFRMFRIL------------KTPTEDIWPGVTSLPDYKNTFPCWSTNQ 248

Human   249 LERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGF 292
            |..:...|....|||.:|.|..||..|....::|.|.:|  :||
  Fly   249 LTNQLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYF--NGF 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL2	XP_047272338.1	STKc_CDKL2_3	2..287	CDD:270836	117/296 (40%)
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	116/295 (39%)