Protein Alignment CDKL2 and Takl1

DIOPT Version :9

• Sequence 1: NP_001317653.1
• Gene: CDKL2 / 8999
• HGNCID: 1782
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_732554.1
• Gene: Takl1 / 318725
• FlyBaseID: FBgn0046689
• Length: 393
• Species: Drosophila melanogaster
• Alignment Length: 422
• Identity: 99/422 - (23%)
• Similarity: 172/422 - (40%)
• Gaps: 108/422 - (25%)

Human     2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNL 66
            ||:     :|.||.|.|.|...::....|.|..|||    :.:||.|.|||..|.::.|||::.:
  Fly    14 EKF-----LGAGSGGAVRKATFQNQEIAVKIFDFLE----ETIKKNAEREITHLSEIDHENVIRV 69

Human    67 LEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQ--KYLFQIINGIGFCHS--HNIIHRDI 127
            :......|:.||:.|:::...|.:.....:..:|.|.|  ::..|....:.:.||  ..|:||||
  Fly    70 IGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSLDRPIVHRDI 134

Human   128 KPENILV-SQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCL 191
            ||:|:|: :|...:|:||||.|..::   ...||...|..|.||| .:..:||....||::.|.:
  Fly   135 KPQNMLLYNQHEDLKICDFGLATDMS---NNKTDMQGTLRYMAPE-AIKHLKYTAKCDVYSFGIM 195

Human   192 VTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKL 256
            :.|:...:                      :| :..|.|.|..:|.::.....|:.|:|......
  Fly   196 LWELMTRQ----------------------LP-YSHLENPNSQYAIMKAISSGEKLPMEAVRSDC 237

Human   257 SEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRK 321
            .|.:..|.:.|:.|:|:|||...|:            |:|..|                     :
  Fly   238 PEGIKQLMECCMDINPEKRPSMKEI------------EKFLGE---------------------Q 269

Human   322 KEKEKDDSLVE--ERKTLVVQDTNAD----------------PKIK-DYKLFKIKGSKI------ 361
            .|...|:..::  :..|:.|...:.|                |.|: .:.:.|.:..::
  Fly   270 YESGTDEDFIKPLDEDTVAVVTYHVDSSGSRIMRVDFWRHQLPSIRMTFPIVKREAERLGKTVVR 334

Human   362 -------DGEKAEKGNRASNASCLHDSRTSHN 386
                   ||::..:  ||...:....||.:||
  Fly   335 EMAKAAADGDREVR--RAEKDTERETSRAAHN 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL2	NP_001317653.1	STKc_CDKL2_3	2..287	CDD:270836	80/289 (28%)
		S_TKc	4..287	CDD:214567	78/287 (27%)
		[NKR]KIAxRE	45..51		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..384		5/20 (25%)
Takl1	NP_732554.1	S_TKc	15..262	CDD:214567	78/282 (28%)
		STKc_TAK1	17..274	CDD:270960	82/320 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910