DRSC/TRiP Functional Genomics Resources

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Protein Alignment: CFLAR and Strica

Sequence 1:NP_001120655.1 Gene:CFLAR HGNCID:1876 Length:480 Species:Homo sapiens
Sequence 2:NP_001260718.1 Gene:Strica FlyBaseID:FBgn0033051 Length:527 Species:Drosophila melanogaster

Alignment Length:346 Identity:61/347 (18%)
Similarity:104/347 (30%) Gaps:135/347 (39%)


Human   165 KTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQ 229
            |.|:....||....||         |..||           |.||....|.:|    :|.:..|.
  Fly   278 KPKVTAVAQSQDAQGT---------ISTSL-----------GISKSSLTKNKL----KPARVYIF 318

Human   230 ESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILG 294
            ..|.|      :.:.:.:...          ..:.::||.||..|..:|:.....::..|.:.:.
  Fly   319 NHERF------DNKNEFRKGS----------AQDVKVLRATFEQLKCKVEVITDATLVTIKKTVR 367

Human   295 QFACMPEHRDYD---SFVCVLVSRG-GSQSVYGVDQTHSGLPLHHIRRMFMGDSCPY-------L 348
                |.:.:|::   :.|.|::|.| ....:...|..:|           :.|...:       |
  Fly   368 ----MLQTKDFEDKSALVLVILSHGTRHDQIAAKDDDYS-----------LDDDVVFPILRNRTL 417

Human   349 AGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSL- 412
            ..|||:.|:|                                              .|..|..| 
  Fly   418 KDKPKLIFVQ----------------------------------------------ACKGDCQLG 436

Human   413 -----LEQSHSSPSLYLQCLSQ-----KLRQERKRPLLDLHIE-LN--GYMYDWNS--------- 455
                 ..|.:.||:..|:|.|.     ..|.|...|.:....| ||  |...|.::         
  Fly   437 GFMTDAAQPNGSPNEILKCYSTYEGFVSFRTEDGTPFIQTLCEALNRSGKTSDIDTIMMNVRQVV 501

Human   456 RVSAKEKYYVWLQHTLRKKLI 476
            ::.:|::....:..||..|.:
  Fly   502 KMQSKDRQIPSVTSTLTSKYV 522

Known Domains:


GeneSequenceDomainRegion External IDIdentity
CFLARNP_001120655.1 Not proteolytically processed and involved in apoptosis inhibition 1..435 51/292 (17%)
Interaction with caspase-8 propeptide 1..305 27/140 (19%)
Interaction with FADD 1..227 15/62 (24%)
Interaction with caspase-8 1..195 9/30 (30%)
DED_c-FLIP_r1 1..80 CDD:260044
DED_c-FLIP_r2 91..171 CDD:260046 2/6 (33%)
Interaction with TRAF1 and TRAF2 192..480 54/320 (17%)
Interaction with caspase-3 192..435 44/265 (17%)
Interaction with caspase-8 subunits p18 and p10 217..480 48/295 (16%)
CASc 244..479 CDD:214521 43/268 (16%)
Caspase 263..358 21/106 (20%)
Interaction with caspase-8 370..480 21/131 (16%)
StricaNP_001260718.1 CASc 311..523 CDD:294037 47/290 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG3573
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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