Protein Alignment CG42514 and Slc46a3

DIOPT Version :10

• Sequence 1: NP_730171.1
• Gene: CG42514 / 8674108
• FlyBaseID: FBgn0260388
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_082148.1
• Gene: Slc46a3 / 71706
• MGIID: 1918956
• Length: 460
• Species: Mus musculus
• Alignment Length: 484
• Identity: 109/484 - (22%)
• Similarity: 208/484 - (42%)
• Gaps: 49/484 - (10%)

  Fly    54 VKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPE------------NE 106
            :|.:.:||.:.|..||..:|..:...:...:......|:|  ...|.|..|            .|
Mouse     1 MKISFIEPAILLNAFAMTLTIPLTAQYVYRRIWEETGNYT--FASNSNGSECDQNKSSSIFAFRE 63

  Fly   107 EFRTKAMLTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIVVNARM 171
            |.:.||.|.|   ||.| :||.:..::....|.:.||..|||||:::..:|....:|.:.:.:..
Mouse    64 EVQKKASLFN---LQVE-MSALIPGLVSTFMLLASSDNHGRKLPMVLSSLGSLGTNTWLCMMSYF 124

  Fly   172 TTWPVQNIIYSATLPSALTGADVAIFASCFAYISD-ISSLQQRTIRVTILDVIYLSAMPMGVA-- 233
            .. |:| ::.::|...||.|.....:.:|||||.| ....:.|.||:.|||.:      :||.
Mouse   125 DL-PLQ-LLIASTFIGALFGNYTTFWGACFAYIVDQQKEYKHRIIRIAILDFM------LGVVTG 181

  Fly   234 -LGSHLFYNVFNQSYADMFTVNASLLALAIIYTLCALKWQTTPRQRSLRELGCCGFWGDFFDKQH 297
             .|....|.:....:...:.:.|.:|.:.:.|.|..|..........:..:.|.....|.|.:.:
Mouse   182 LTGLSSGYFIRELGFVWSYFITAMVLIVNLAYILFFLNDPIKESSSQIVTMSCIESLKDLFYRTY 246

  Fly   298 VKDSLAVLVKPRKGHRRSFLIILLVSMALYTFQRDEGQYLY-MYTLG-KFDWDVSAYSNFKTFKS 360
                  :|.|.....|::.|.:|:.::.:|.|.......:: :|.|| ...|: ..|..:.:...
Mouse   247 ------MLFKNGSSKRQALLCLLIFTLVIYFFVIIGISPIFTLYELGPPLCWN-EVYIGYGSALG 304

  Fly   361 SAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAV--VCSLGPIVG 423
            |...::..|.:.|.:..|  :|..|.:||.:...:......|...|.:::...:  :.::.|:
Mouse   305 SVSFLSSFLGIWLFSYCL--KDIHIAYIGIFTTMVGMTLAAFTRTTLMMFLVRIPFIFTIMPL-- 365

  Fly   424 PMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRRTQNTNHGGNVFILTIATQIAV 488
            .::|:|.||:|.::|:|.:||.::..:......|...||.:|..|. ..:.|.:|:|:....:..
Mouse   366 SVLRSMLSKVVHSTEQGALFACIAFLETLAGVTSTSAYSGIYSATV-AWYPGFIFLLSAGLLVLP 429

  Fly   489 FVMILCLHIV---LGKNSLAVPEVPEKES 514
            .:.:.|:..:   .|..:|.|.|.|.:.:
Mouse   430 AISLCCVKSIGWEEGSYTLLVHEEPSEHT 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_SLC46	56..495	CDD:340944	102/458 (22%)
Slc46a3	NP_082148.1	MFS	3..437	CDD:475125	103/459 (22%)
		Tyrosine-based lysosomal-sorting motif. /evidence=ECO:0000250|UniProtKB:Q7Z3Q1	446..449		0/2 (0%)