DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and Slc46a3

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001343931.1	Gene:	Slc46a3 / 71706	MGIID:	1918956	Length:	460	Species:	Mus musculus

Alignment Length:	484	Identity:	109/484 - (22%)
Similarity:	208/484 - (42%)	Gaps:	49/484 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPE------------NE 106
            :|.:.:||.:.|..||..:|..:...:...:......|:|  ...|.|..|            .|
Mouse     1 MKISFIEPAILLNAFAMTLTIPLTAQYVYRRIWEETGNYT--FASNSNGSECDQNKSSSIFAFRE 63

  Fly   107 EFRTKAMLTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIVVNARM 171
            |.:.||.|.|   ||.| :||.:..::....|.:.||..|||||:::..:|....:|.:.:.:..
Mouse    64 EVQKKASLFN---LQVE-MSALIPGLVSTFMLLASSDNHGRKLPMVLSSLGSLGTNTWLCMMSYF 124

  Fly   172 TTWPVQNIIYSATLPSALTGADVAIFASCFAYISD-ISSLQQRTIRVTILDVIYLSAMPMGVA-- 233
            .. |:| ::.::|...||.|.....:.:|||||.| ....:.|.||:.|||.:      :||.
Mouse   125 DL-PLQ-LLIASTFIGALFGNYTTFWGACFAYIVDQQKEYKHRIIRIAILDFM------LGVVTG 181

  Fly   234 -LGSHLFYNVFNQSYADMFTVNASLLALAIIYTLCALKWQTTPRQRSLRELGCCGFWGDFFDKQH 297
             .|....|.:....:...:.:.|.:|.:.:.|.|..|..........:..:.|.....|.|.:.:
Mouse   182 LTGLSSGYFIRELGFVWSYFITAMVLIVNLAYILFFLNDPIKESSSQIVTMSCIESLKDLFYRTY 246

  Fly   298 VKDSLAVLVKPRKGHRRSFLIILLVSMALYTFQRDEGQYLY-MYTLG-KFDWDVSAYSNFKTFKS 360
                  :|.|.....|::.|.:|:.::.:|.|.......:: :|.|| ...|: ..|..:.:...
Mouse   247 ------MLFKNGSSKRQALLCLLIFTLVIYFFVIIGISPIFTLYELGPPLCWN-EVYIGYGSALG 304

  Fly   361 SAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAV--VCSLGPIVG 423
            |...::..|.:.|.:..|  :|..|.:||.:...:......|...|.:::...:  :.::.|:
Mouse   305 SVSFLSSFLGIWLFSYCL--KDIHIAYIGIFTTMVGMTLAAFTRTTLMMFLVRIPFIFTIMPL-- 365

  Fly   424 PMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRRTQNTNHGGNVFILTIATQIAV 488
            .::|:|.||:|.::|:|.:||.::..:......|...||.:|..|. ..:.|.:|:|:....:..
Mouse   366 SVLRSMLSKVVHSTEQGALFACIAFLETLAGVTSTSAYSGIYSATV-AWYPGFIFLLSAGLLVLP 429

  Fly   489 FVMILCLHIV---LGKNSLAVPEVPEKES 514
            .:.:.|:..:   .|..:|.|.|.|.:.:
Mouse   430 AISLCCVKSIGWEEGSYTLLVHEEPSEHT 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	72/336 (21%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	80/370 (22%)
Slc46a3	NP_001343931.1	MFS	3..437	CDD:391944	103/459 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.860