Protein Alignment CG42594 and twk-34

DIOPT Version :10

• Sequence 1: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_506906.3
• Gene: twk-34 / 180054
• WormBaseID: WBGene00006686
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 698
• Identity: 114/698 - (16%)
• Similarity: 192/698 - (27%)
• Gaps: 330/698 - (47%)

  Fly   166 PHPPLTSIAGSTAGSNNSNISGSNMSSNSNCGTLKSNAKLLPLQLMATPPSRKEPLTPAHPQAAS 230
            |.||:.::|.:..                     ....||.||:......:|..|.....|.:.|
 Worm    38 PEPPVNNVAPAEE---------------------SQEPKLTPLEERERKKNRVHPTMQNLPLSRS 81

  Fly   231 IQAQAQVQHQLQQQHQQQQQQQQQQHQQQQQ---QQQQRQRKRQGWCSCFSSTPGGGHAGGGVGG 292
            ..:.:..:.:..:::.::........|:.|.   |.|:|.:.||...|..||
 Worm    82 NSSTSLSKVEAVEKYYERNAHTVSGFQRNQDTFGQLQRRYKPRQDAISVLSS------------- 133

  Fly   293 GVAAGETGKTPPGYGSKEKKKSRKATSQTVWSAL------LTNLGICMLLLAYTLLGSFIFLTIE 351
                      |...|.......|.......|.|.      |.::.:.:::|:||:.|:|:|.|:|
 Worm   134 ----------PGALGEPVMPTDRHFDRSMYWFAFHRKQIGLRHIMVALMVLSYTIFGAFMFWTVE 188

  Fly   352 --NEDSALLHQQHTLASTKRNLAGLGIGAAGIGSSIYQQQQQQQQQRTPHQQQQQHQAVQGRHAD 414
              ||.:..|.:...|    .||  |.|.|..|...:.
 Worm   189 SRNERAVTLERVTNL----ENL--LNILATNITEIVN---------------------------- 219

  Fly   415 NDTMAAAAAAVAAQGTLAGSASAGGLNPFGQPASSGEFVYGLDGMDATDLEAGGMPQFALSPDTY 479
                                      ||                 :.|..||
 Worm   220 --------------------------NP-----------------NTTTTEA------------- 228

  Fly   480 DVRQRTIENIWDITVSLNILYKENWTKLAALEIAKFQDQLIKRLNEDVMLQLSHDDVANAPSSSS 544
                           .:.:..:|.:..|..|| .:::.....:|.:.
 Worm   229 ---------------EMQVYIREAYVSLMKLE-GQYKGSTYYKLEDH------------------ 259

  Fly   545 SSSSSSSSSSSSTGASGVPGSNNPATEAVLLHTHYHHHRAGGVGGVAVGGGPPHEWNFAKAFLYS 609
                                                              |...:|.|..||.:|
 Worm   260 --------------------------------------------------GKNWKWTFESAFFFS 274

  Fly   610 LTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTGSILARVAREVFSKALCCCLCSNC 674
            :.|.||.|||::||.:.||:::...|.|..:|:|||.|...|..
 Worm   275 MNVYTTTGYGSIAPESILGQVLVCLYGFIFVPVTLVALRDLGQF--------------------- 318

  Fly   675 GYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVRDVFHATPEKDAGAGAPPPNAGGPVG 739
             :..:..|..|:..:|.|      |:....::
 Worm   319 -FLVHLTKLYAQLIQRWR------EINGDTSI--------------------------------- 343

  Fly   740 SVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYIVFGAAVLYRLEKWPILDG------- 797
                  |::.:             |..||..|..::.:|:.|....::..::   |.|
 Worm   344 ------DVNEI-------------IKIPIKACLLLLALYLAFCTIFIHVFDE---LSGDESGSGM 386

  Fly   798 -----IYFCFMSLSTIGFGDMLPGLRRESNAT-TWFCSVYIMSGMTLT 839
                 .||.|:||||||.||::|     :||| :...|:....||.||
 Worm   387 SVFLCFYFSFISLSTIGLGDIMP-----NNATFSPIISIMFFFGMALT 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301	23/56 (41%)
		Ion_trans_2	774..846	CDD:462301	24/79 (30%)
twk-34	NP_506906.3	Ion_trans_2	250..319	CDD:462301	25/158 (16%)
		Ion_trans_2	366..442	CDD:462301	23/72 (32%)