Protein Alignment Gyc76C and Gucy2d

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_077356.1
• Gene: Gucy2d / 79222
• RGDID: 620438
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 1210
• Identity: 367/1210 - (30%)
• Similarity: 551/1210 - (45%)
• Gaps: 209/1210 - (17%)

  Fly     3 RWPFNLL--LLLSVAVRDCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVNKD-- 60
            |||...|  |||.:.:...|....|..||.|.....|   .:.|..|    |..:|.|.:|:|
  Rat    32 RWPGPGLPGLLLLLLLPSPSAFSAVFKVGVLGPWACDPIFARARPDL----AARLATDRLNRDLA 92

  Fly    61 --------PNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGP--CYVEAIVSQSR 115
                    ..|||...|      |.|.....:.|:|.     ::.:.||..|  |....:::|..
  Rat    93 LDGGPWFEVTLLPEPCL------TPGSLGAVSSALTR-----VSGLVGPVNPAACRPAELLAQEA 146

  Fly   116 NIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVWSPVADLLKD 178
            .:.::.:.|...||:     ..|.|..|....:|..||:.:.|.:.:::.  :|:|......|..
  Rat   147 GVALVPWGCPGTRAA-----GTTAPAVTPAADALYVLLKAFRWARVALITAPQDLWVEAGRALST 206

  Fly   179 QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSM 243
            ....|.:.:....|.:.:.:....:.|...|.|...::|...|:.    |.||...... .:.:.
  Rat   207 ALRARGLPVALVTSMVPSDLSGAREALRRIRDGPRVRVVIMVMHS----VLLGGEEQRY-LLEAA 266

  Fly   244 ETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTK 308
            |..|| ..|..:.:..|.:.|:.....:.|......:.:...|..        .|.:....||..
  Rat   267 EELGL-TDGSLVFLPFDTLHYALSPGPEALAAFVNSSKLRRAHDA--------VLTLTRRCPPGG 322

  Fly   309 DYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLT 373
            ......::.|:: .:.|.:|::          |.:|.....:||:|.|.|..|       ||.
  Rat   323 SVQDSLRRAQEH-QELPLDLDL----------KQVSPLFGTIYDAVFLLAGGV-------TRA-- 367

  Fly   374 DDVIFEVASNGTRVIDTIIKNRT-------YMSITG-----SKIKIDQYGDSEGNFSVLAYKPHK 426
                 ..|..|..|....:..:.       :..|.|     |.:.:|.....|..|:.
  Rat   368 -----RAAVGGGWVSGASVARQMREAQVFGFCGILGRTEEPSFVLLDTDAAGERLFTT------- 420

  Fly   427 WNNSNNMPCNYHMV-PVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGF-ANELCK---KD 486
                       |:: ||....:....|        :.:|.|...|..:|.|.| .:.:|.   :.
  Rat   421 -----------HLLDPVLGSLRSAGTP--------VHFPRGAPAPGPDPSCWFDPDVICNGGVEP 466

  Fly   487 DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELE-IEGLLWKIDPNEI------------KGY 538
            ...:...:..:|:|:    :|.......|...:.:: :.|      ||:|            :|
  Rat   467 GLVFVGFLLVIVVGL----TGAFLAHYLRHRLLHMQMVSG------PNKIILTLEDVTFLHPQG- 520

  Fly   539 SGNEIVSSPSKVSLMSAQSYGSRWTN---------QFVTSTGRLRGAVVRIKELKFPRKRDISRE 594
                  .|..||:..|..|..:|.|:         |..|:.|...|..|.:|  |||.:..::..
  Rat   521 ------GSSRKVAQGSRSSLATRSTSDIRSVPSQPQESTNIGLYEGDWVWLK--KFPGEHHMAIR 577

  Fly   595 IMKEMRL--LRELRHDNINSFIGASVEPTR----------ILLVTDYCAKGSLYDIIENEDIKLD 647
            ...:|..  ||||||:|:..::|..:..|.          :.:|:::||:|||:|::...|||||
  Rat   578 PATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLD 642

  Fly   648 DLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQ 712
            .:|.:||:.||||||.|:|: :.|.||.|||.||||..|::|:|||.|...|.:.  ...:.|..
  Rat   643 WMFKSSLLLDLIKGMRYLHH-RGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEA--QRVLPEPP 704

  Fly   713 HYRNQLWRAPELLRN---HIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLK 774
            ...:|||.||||||:   ...|:..|||::..|||.|:..|..|:..:...|:|::..|:..|
  Rat   705 SAEDQLWTAPELLRDPALERRGTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSPP-- 767

  Fly   775 GEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEM 839
                  |....::..:..|...:..:..||||.||.||...:..:..|.:..|:..||:|.|:.|
  Rat   768 ------PLCRPLVSMDQAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRM 826

  Fly   840 MEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVG 904
            :|:|::||||::.|||..|.:||.||:.||.:|||.||||.|.||..|||..::.||:|||||||
  Rat   827 LEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVG 891

  Fly   905 FTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMA 969
            ||.:||.|.|::||:.||||||:||.||..:||||||||||||||.||||.:||.|||.|||:|:
  Rat   892 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMS 956

  Fly   970 LELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKI 1034
            |::|.||...|:.|.|...:::|||:|:||.|||||||||||||||||||||||||||.|...:|
  Rat   957 LDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRI 1021

  Fly  1035 HISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRP- 1098
            |::......|..|..|:..|.||...:||||...|:||.|...                 |::|
  Rat  1022 HVNMSTVRILRALDQGFQMECRGRTELKGKGVEDTYWLVGRVG-----------------FNKPI 1069

  Fly  1099 RKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGEST 1138
            .|.|.|.|.:....|.....   ...|:..:.:|..|:.|
  Rat  1070 PKPPDLQPGASNHGISLQEI---PPERRKKLEKARPGQFT 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	83/448 (19%)
		PK_GC-A_B	543..827	CDD:270944	101/307 (33%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	83/452 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..552		9/38 (24%)
		PK_GC-2D	540..814	CDD:270945	94/286 (33%)
		HNOBA	<823..868	CDD:462234	25/44 (57%)
		CYCc	848..1039	CDD:214485	119/190 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1069..1108		9/41 (22%)