Protein Alignment Gyc76C and Gucy1a1

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_068696.2
• Gene: Gucy1a1 / 60596
• MGIID: 1926562
• Length: 691
• Species: Mus musculus
• Alignment Length: 516
• Identity: 145/516 - (28%)
• Similarity: 220/516 - (42%)
• Gaps: 143/516 - (27%)

  Fly   608 DNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDI---KLDDLFI-----------ASLIHDL 658
            |.:|||       :.:|..:.:|.:......:|:..|   ..|..|:           |.|:..:
Mouse   161 DFLNSF-------STLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGI 218

  Fly   659 IKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPE 723
            ||..     ::::|..:::.|......|             ..|.|         :.||    |.
Mouse   219 IKAA-----ARILYESHVEVSLMPPCFR-------------SDCTE---------FVNQ----PY 252

  Fly   724 LLRN-HIHGSQ----KGDVYAFAIIMYEIFSRKGPFGQI---NFEPKEIVDYVKKLPLKGEDPFR 780
            ||.: |:..::    .|...:..:|...:|.:..||..:   :....::.:.:::|..|.:...:
Mouse   253 LLYSVHVKSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGK 317

  Fly   781 PEVESIIEAESCPDYVLACIRDCWAEDPEERPEFS----------VIRNRLKKMRGGKTKNIMD- 834
            |..|...|       :|.         |:....||          |||.|.......|:..:||
Mouse   318 PNFEEFFE-------ILT---------PKINQTFSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDL 366

  Fly   835 --QMMEMMEKYA----------------------------NNLEDIVT--ERTR----------- 856
              ||:.::|..|                            |.|.|:|.  |:.|
Mouse   367 KGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGK 431

  Fly   857 ----------LLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAE 911
                      .|.|||.:|.|||..:.|..||::|..||.|:...:..||:.|||||||||:.::
Mouse   432 LKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLFSDIVGFTAICSQ 496

  Fly   912 STPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAV 976
            .:||||:..||.|||.||:.....||||||||||||.|..||. :..|.||.:||.|||:::...
Mouse   497 CSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLH-RESDTHAVQIALMALKMMELS 560

  Fly   977 KQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            .:....|  .|.:|:|||:|:|.|.|||||:.||||||||:.|..|::.||.....||::|
Mouse   561 NEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593
		PK_GC-A_B	543..827	CDD:270944	43/250 (17%)
		HNOBA	<833..881	CDD:462234	23/101 (23%)
		CYCc	860..1052	CDD:214485	88/178 (49%)
Gucy1a1	NP_068696.2	HNOBA	277..466	CDD:462234	41/204 (20%)
		Guanylate_cyc	472..643	CDD:425528	75/151 (50%)