Protein Alignment Gyc76C and adcy1b

DIOPT Version :10

• Sequence 1: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_073776301.1
• Gene: adcy1b / 569499
• ZFINID: ZDB-GENE-100805-1
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1062
• Identity: 220/1062 - (20%)
• Similarity: 378/1062 - (35%)
• Gaps: 301/1062 - (28%)

  Fly   213 WYQLVQNTMNRTRIYV----------------FLGAANSLVDFMSSME---------TAGLFARG 252
            |..||.||:..|.:.|                ||.|.|.:.:.: .||         ...|..|.
Zfish   189 WRSLVANTLLFTGVNVSGLFVRILTERAQRKAFLQARNCIEERL-RMEDENEKQERLLMSLLPRN 252

  Fly   253 EYMVIFVDMMVYSEREAEK-YLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQFTKQ 316
            ..|.:..|.:...||...| |::|.|.::.:                        ..|.:.||..
Zfish   253 VAMEMKEDFLKPPERIFHKIYIQRHDNVSIL------------------------FADIVGFTSL 293

  Fly   317 VQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYA---WAVDKMLREETRVLTDDVIF 378
            ..:.:::     |:.:|..|. |.||..:........:|:..   :.|..:.:.:|     |...
Zfish   294 ASQCTAQ-----ELVKLLNEL-FGKFDELATENHCRRIKILGDCYYCVSGLTQPKT-----DHAH 347

  Fly   379 EVASNGTRVIDTI--IKNRTYMSI-------TGSKIKIDQYGDSEGNFSVLAYKPHKWNN----- 429
            .....|..:||||  :...|.:.:       || ::.....|..:..:.|       |:|
Zfish   348 CCVEMGLDMIDTITSVAEATEVDLNMRVGLHTG-RVLCGVLGLRKWQYDV-------WSNDVTLA 404

  Fly   430 ----SNNMPCNYHMVPVAYFHQGEEHPEYKLING--SIDWPSGGEKPADEPMCGFANELCKKD-- 486
                :..:|...|:.          ....:.:||  .::..:|.|:.|         .|.|.|
Zfish   405 NMMEAGGLPGKVHIT----------RSTLECLNGDYEVEPGNGRERHA---------FLLKHDIE 450

  Fly   487 -----DTHYTSTVAAVVLGVL---------LFCSGVITMSIYRK-WKIELEIEGLLWKIDPNEIK 536
                 .:|.......::|..:         ..|..::.:...|| :|.|:....::     |...
Zfish   451 TFFIVPSHRRKIFPGLILSDIKPAKKMKFKTVCYLLVQLMHCRKMFKAEIPFSNVM-----NCED 510

  Fly   537 GYSGNEIVSSPSKV------SLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREI 595
            |.....:.|:|.|:      :..:.||......|:::.          |:.|   .|:.:.....
Zfish   511 GDKRRVLRSAPEKLRNRTPTTASAPQSSPGTRVNRYIN----------RLIE---ARQTESDTAD 562

  Fly   596 MKEMRLL-----RELRHDNINS--FIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIAS 653
            :..:.|:     ||.|:..:|.  |.||.|  ..:|||.   ..|.||.:|..:...:..|.:..
Zfish   563 LNYLTLMYRDSERERRYHQLNDEYFTGAVV--LSLLLVV---LLGFLYLLIIPQGTVVLVLLVFC 622

  Fly   654 LIHDLIKGMIYIHNSQL-VYHG----NLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQH 713
            :.. |:..::|:|.::: .:.|    .::::.||.....:..|.       :.|.    :|
Zfish   623 ICF-LVVCIMYLHITRVQCFPGCLTIQIRTALCVFIVLLIYAVA-------QACV----VG---- 671

  Fly   714 YRNQLW------------RAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEI-- 764
            ....||            .|..|.|........|..|||...|....| ...|.::::.||.|
Zfish   672 CMPWLWPSNSTRSIVIIDAAAGLNRTMAELPCAGAQYAFLCCMLGTLS-MALFLRVSWIPKMILL 735

  Fly   765 ----VDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMR 825
                |.|:..|.|.|   ||          ....:.|..:|..       .|..|::   |....
Zfish   736 LLLLVLYITILELSG---FR----------RASGWALLSVRGL-------EPLLSLL---LFSTA 777

  Fly   826 GGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTED--LLHRMLPQSVAEKLTMG---- 884
            .......:|..:.:...:|...|:   ||..:   ||:|.::  :|..:||..||:...:.
Zfish   778 VALHSRQLDLKLRLDFLWATQAEE---ERDGM---EKVKLDNKRILFNLLPVHVAQHFLLSNPRN 836

  Fly   885 -------QGVEPVSYDLVTIYFSDIVGFT----AMSAESTPLQVVNFLNDLYTVFDRII--RGY- 935
                   |.:...||..|.:.|:.|..|.    .:...:..::.:..||::...||.::  ..|
Zfish   837 MVRSSEHQDLYYQSYAQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYK 901

  Fly   936 DVYKVETIGDAYMVVSGLPIKNGDR-------HAGEIASMALELLHAVKQHRIAHRPNETLKLRI 993
            |:.|::|||..||...||....|.:       |...||..|:|:...:.:  |.::......||:
Zfish   902 DIEKIKTIGSTYMSAVGLVPTIGTKAKKSTATHLSTIADFAIEMFDVLDE--INYQSYNDFVLRV 964

  Fly   994 GMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGL 1058
            |::.|||||||:|...|:|.::|:|||.||||:|.|...||.::......|.   ..|....||.
Zfish   965 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQVTEDVYRLLQ---NNYDLMCRGN 1026

  Fly  1059 VNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGS 1123
            |::||||.::|::|.|                                .::.|.|:|.|..|...
Zfish  1027 VSVKGKGQMLTYFLEG--------------------------------KAQDPGIRAPHHTGGLE 1059

  Fly  1124 RRQSTVPRAMDGESTYSLQGSV 1145
            ||...:.|.   .||.:..|||
Zfish  1060 RRVHAIART---SSTQTKAGSV 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	50/278 (18%)
		PK_GC-A_B	543..827	CDD:270944	62/319 (19%)
		HNOBA	<833..881	CDD:462234	13/49 (27%)
		CYCc	860..1052	CDD:214485	62/218 (28%)
adcy1b	XP_073776301.1	None