Protein Alignment Nost and Nost

DIOPT Version :10

• Sequence 1: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: XP_061510404.1
• Gene: Nost / 1272556
• VectorBaseID: AGAMI1_002221
• Length: 1112
• Species: Anopheles gambiae
• Alignment Length: 1267
• Identity: 540/1267 - (42%)
• Similarity: 718/1267 - (56%)
• Gaps: 249/1267 - (19%)

  Fly   139 NIGSNNNQKGGAKGFLGRIKRYS-VLGNKLGRRNLGSMNLNPPNNVVDNSVSPTKLHTGSYNMTG 202
            ::..:.:.|..:..|....|||| |:|.:..|:..|...         ....|.   :.||:|.|
Mosquito    16 SLAGSKHGKSSSNLFDKLSKRYSGVIGARFLRKTPGRKG---------GVAEPL---SDSYDMCG 68

  Fly   203 SHSDDHRLEIGAPILISTTTLDTDRFDV-TEARLKQ--------IGGGIAQTSSIVRTLTPRSSD 258
            :.|||.|.|||||:|||.|.    :||. |::.::|        |||.:...:      ||.:|:
Mosquito    69 NRSDDFRPEIGAPVLISKTM----KFDFDTDSEVEQLPLPSVPTIGGRVRSVA------TPSTSE 123

  Fly   259 EEE---FVDARSS------------PQQMERDEDLQIADDQVE--------KNDRDQYGHQFQLP 300
            :.|   ||||.||            |:........|  |:.|.        :..|.:..|...|
Mosquito   124 DSENDVFVDANSSLPNFGEIKFTFLPESNNNCRSFQ--DENVRHSGGGHMLEKSRSKSAHNLHL- 185

  Fly   301 KKQHREEEMGDLKYLDDLEEPEQFETPKHEVEEKLLTANQDVKRPITPITIAIDPPIRR----PR 361
              .|...||          .....:.|...:...  |||..:   :||:::...|.:..    ||
Mosquito   186 --HHAGSEM----------RLSLAKAPSLNISAS--TANGAI---VTPLSVPNSPAVESIYDFPR 233

  Fly   362 IAR----QQRQSQSVQNLHRSELKVYLHKSNSVALDMNVTAPAKLGLDLNLPELPELYGASELSL 422
            ..|    ::....|..:|.||.     |..|.::                            |||
Mosquito   234 STRSDGIRKPHGDSSYDLTRSH-----HVLNEIS----------------------------LSL 265

  Fly   423 AASDNK--ENLPAVKPSAERSPIPNGGFMAQQPHFKSLDSFHLNTRSHSNQSSQQSSRQSLACSS 485
            .:.|:.  :|||:  |:..|..:|..                         ||.:..|.|.|.||
Mosquito   266 VSDDSHLYQNLPS--PADARYDVPPA-------------------------SSGRRRRDSSASSS 303

  Fly   486 -SNGEYDFDLKSVSYQSL-----NAQNLFVSIDELQELTRQINE-TEDFGKEI--DLEYCAHRDQ 541
             |..|.:|||||.|:|||     .|..|.||:|||.|||||||: |...|..:  ..|||.||.|
Mosquito   304 NSTQEEEFDLKSASFQSLADAGPGANQLAVSMDELDELTRQINQSTVGLGTPLPDSDEYCEHRKQ 368

  Fly   542 LRPSERRITLLKNKN---QTLINFNHNKEKLRKGWHGMKHWLGEEGSKIKEAVRQQTPLKRL--- 600
            |.|||||:||:||::   :.||:|:..|.|:.|.|.|.|.|:|||..:|:|.|::...::|:
Mosquito   369 LHPSERRLTLMKNRSVSGKHLIDFDRRKAKITKKWSGFKSWIGEEQGRIREVVQKHAAMQRVGVE 433

  Fly   601 -------AQSRSNLNQSTADA-SRQSM------SPERT--QRDVTESCEDVTERTEMESSMSHRN 649
                   |..|:|.:.:.:|. |||.:      :||.:  |||.|.|.||    .|...:|..::
Mosquito   434 SSGTGGKAVKRANSDLTASDQDSRQDVEGTVVTTPESSVVQRDRTLSSED----REGARTMHRKS 494

  Fly   650 SEEDLSPHAKRFKDEGQNGFEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKA 714
            :..::.        ||||||||:||:|||||||.|:|:.:|.||.:.|.:|:|||||:|||||||
Mosquito   495 ANAEIL--------EGQNGFEEVRRFVKQGGDFGKDLVAILHERTEIEQLYAKSLSKIANKLNKA 551

  Fly   715 GREIPGSVADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARV 779
            .|::||::|::||.|:||:|.||::|||.:.||.:|:|||||.|:|..|||||.:|:||||:||:
Mosquito   552 CRDLPGTIAESWRSVSTELEGRSEVHRQFSNSLAEEVVKPLKTVIENQHKARKTIETNVDKSARI 616

  Fly   780 LGEWRASEAKAKKASHTAARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVK 844
            |.|||.:|.||||.||.|||||||||||||||::|::|||.|||     :.:||::|.:|||..|
Mosquito   617 LAEWRTAEIKAKKNSHGAARENEKLQDAMLDVKLQRTPSIGLLH-----KTSEKDVKVSEKDSSK 676

  Fly   845 LDNKRKKAEEAVKRADVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFAQQYARL 909
            |:.||||||||||:|||||||||:|:|||||||||:|||||:.||:.|.|||.....:...|.:|
Mosquito   677 LEGKRKKAEEAVKKADVEYYTLCIRAERARVDWEMSVLRGSSMLQTLESQRLAQFKTYVTDYLKL 741

  Fly   910 ISDMNPILGGLSTRLQPQLDACNVAKDMQVVRHIRRNSEGPSEQLLPDFYCEHTTLAMNRERRKH 974
            .::|:|:|.....||.||:..|:||||:.|:::|||.:||||||||||||||||||||||||||.
Mosquito   742 SAEMSPLLTKTIDRLSPQVAMCSVAKDLDVLKNIRRATEGPSEQLLPDFYCEHTTLAMNRERRKQ 806

  Fly   975 ALIKLLQLVKTDLERERRSRDGLRGLSQSL--NHQEHQNITDKLYHIRSMLTYLEGARLKLHSAL 1037
            :|:|||||::.||:||||||:||:|.||:|  |.:.:|||.|||||||||||||||||.||.|||
Mosquito   807 SLVKLLQLIRQDLDRERRSRNGLKGFSQTLDKNGESNQNIADKLYHIRSMLTYLEGARYKLQSAL 871

  Fly  1038 LELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQTQQSTSMLAHDITDITTNHED 1102
            ||||||||::|||||||.|||||||||.|:||||.|||:....|......:.|:..|.|.::  |
Mosquito   872 LELDHKPRSSHPLAQHIQITRDRTGLQTSVLKVPLWLKHEQDDQEGTQEPVTANGQTTILSS--D 934

  Fly  1103 ELPDENCSHLHSSSHSNNNSNGSCTDVSSVVKPFNRSKSN-IETNFTSQPKIISTTNAAIAVSVK 1166
            :..|:.|..:.:.           |.:..:|..:.|:..| .|..:|       ||.|..:|
Mosquito   935 DSSDQGCLDIKND-----------TLIKHIVHKYARNGCNGDEGQYT-------TTKAGKSV--- 978

  Fly  1167 SKTLANLQDGHHNNQQHHHHHHNHHSDRGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQ 1231
                      |.::     |||....|||.|||.|||.|||||||||||||::    :....|.|
Mosquito   979 ----------HQDD-----HHHGPAWDRGVADGVSNQPDSDFDEFSSQDEDED----RCSVAPKQ 1024

  Fly  1232 SQQQQQQPLLQNPTINGQVQTQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPG 1296
            ..:....|.|.|......|.    :.:|..       |...|||||:||::|||||||||||.||
Mosquito  1025 MLENGCHPALANGASPASVD----HPDAVA-------GQPVILGRCRALFNYTPKLYDELELQPG 1078

  Fly  1297 DIIEVHAKQDDGWWLGALRNHIGIFPATYVEE 1328
            ||:|||.||:|||||||||..|||||||||||
Mosquito  1079 DILEVHIKQEDGWWLGALRGQIGIFPATYVEE 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	155/244 (64%)
		SH3_Nostrin	1276..1328	CDD:212757	42/51 (82%)
Nost	XP_061510404.1	None