Protein Alignment DNF1 and CG33298

DIOPT Version :10

• Sequence 1: NP_011093.3
• Gene: DNF1 / 856913
• SGDID: S000000968
• Length: 1571
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1448
• Identity: 426/1448 - (29%)
• Similarity: 650/1448 - (44%)
• Gaps: 343/1448 - (23%)

Yeast   133 RSKTLKWARKNIPNP-FEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKI 196
            ||:::...|:....| ::..|..:.:.|.....:..|||..|..:| ....:..:|..|:..|||
  Fly   192 RSESIYTLRRTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVP-PKTPKRDHPNGQFVGNKI 255

Yeast   197 RTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIE 261
            ||||||.|:|:|||:|.|||..||:||:.:::|............::.:|::.::.:||:||..|
  Fly   256 RTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFE 320

Yeast   262 DSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKR 326
            |.||...|..:|||...:.:| |.|           |:||..
  Fly   321 DRRRRASDKRINNTTCRVYDG-ETE-----------RYKKVK----------------------- 350

Yeast   327 MQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDC 391
                                                                             
  Fly   351 ----------------------------------------------------------------- 350

Yeast   392 KFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTI 456
                  |:.::|||||.:.||:.:||||:||.|||..|.||::|.:||||||||.|:.::....:
  Fly   351 ------WQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEM 409

Yeast   457 RT----SKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKW 517
            ::    ||.::|    :|::.|.:.||.:.|.:..   ..||  ..||:...:|||...|:||.:
  Fly   410 QSIFVPSKFVSR----VEADAPTTKLYRFHGALIH---PTGE--RVPISTECLLLRESRLKNTDY 465

Yeast   518 AMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSR 582
            ..|:|::.|.:||.|||:.....|:|::.:::|..|:...::|.|||.|..|...::.     |.
  Fly   466 IEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWL-----SS 525

Yeast   583 FS-YEFGTIAGSAATNGFVS---FWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKL 643
            |: :....:..:..|....|   ||..:::.|.::|:|||:::|:.|..|...|:.:|.|::|:.
  Fly   526 FTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAET 590

Yeast   644 DYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDV 708
            :.....::.||:::|||:::||:|||||||:|.|.|::|.:||..|....:| |..:..:.|
  Fly   591 NKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSE-LEKIYSKPG--- 651

Yeast   709 ETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFV----------------RDLKG 757
                  ..|......|.:..::..|:..:...|.....  :||:                ||:..
  Fly   652 ------APAPPLIPNDNLNSDMAQLTQGTYLTPHAQRI--QEFLVVLAICNTVIVGAAPHRDMMN 708

Yeast   758 ASG--EVQQ-------------------------------------------------RCCE--- 768
            |||  ||||                                                 |..|
  Fly   709 ASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRS 773

Yeast   769 -------HFMLAL-ALCH-------SVLVEANPDNP----------------------------- 789
                   :.:.|| |..|       |...|::|::.
  Fly   774 VTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINS 838

Yeast   790 ---------------KKLDL------------------KAQSPDEAALVATARDVGFSFVGKTKK 821
                           |::.|                  :|:||||.|||..|.......:.::..
  Fly   839 KITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPN 903

Yeast   822 GLIIE--MQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQ 884
            .:::.  |.|..:|:|||.:|.|:||||.||.:|:..|     ....:|..|||||.|...|...
  Fly   904 QILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIG-----SQEIVLYTKGADSSIMPVLVPC 963

Yeast   885 SGSNSEAIL-EKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVA 948
            |.::.|.|| |:|...|::||.||||.|.:|:|.|:.::|..|..::.....||.|||..|....
  Fly   964 SHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSF 1028

Yeast   949 DSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELL 1013
            ..:|..|.|||.|.||||||||||:.|..|..|||.:|||||||.||||||.:|..|...:|||:
  Fly  1029 AKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELI 1093

Yeast  1014 VIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALK 1078
            .:.....|..|          ..::.||.:..|    ::............|...|:|:||..|.
  Fly  1094 RLTARSRDAAE----------TAINFYLTDMEN----DKTTSTLGYGQSLRKKQRALVVDGKTLT 1144

Yeast  1079 LALYGEDIRRK----FLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQ 1139
            ..|   |.:.|    ||.|.|.|.:|||||.:|.|||.:||:||:.|::.|||||||:|||:|||
  Fly  1145 FIL---DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQ 1206

Yeast  1140 SADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFW 1204
            .||||:||:|:||.||||.:|:.:.:||||.||:|.||.|.|.||:.||..|||||..|...:||
  Fly  1207 MADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFW 1271

Yeast  1205 YGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRK 1269
            |.:|..|.|..:.:..|:|.|||.|||||.:.:|:.|:.|.:.:.|..|.||:.|.|...:....
  Fly  1272 YQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHD 1336

Yeast  1270 FLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGV--YVTTIAVISCNTYVLLH-- 1330
            |...:||.||||::.||.....|.::              .||:  :.|||.. ||....|:|
  Fly  1337 FWLILLDALYQSLVIFFVALCAYAES--------------DVGIWEFGTTITA-SCLFANLVHCA 1386

Yeast  1331 -QYR-WDWFSGLFIALSC----LVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFC 1389
             :.| |.....|.|.||.    |....:..:..:....|..:......:.:...|.|..::.:..
  Fly  1387 IEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVA 1451

Yeast  1390 LLPRFTYDSFQKFFYPTD 1407
            :|||....:.:....|.|
  Fly  1452 VLPRLLLTTVRISLCPDD 1469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNF1	NP_011093.3	ATPase-Plipid	191..1413	CDD:273734	413/1389 (30%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	388/1256 (31%)