Protein Alignment YARS1 and MetRS-m

DIOPT Version :10

• Sequence 1: NP_003671.1
• Gene: YARS1 / 8565
• HGNCID: 12840
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_650348.1
• Gene: MetRS-m / 41733
• FlyBaseID: FBgn0027083
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 110/537 - (20%)
• Similarity: 188/537 - (35%)
• Gaps: 168/537 - (31%)

Human    34 RELKI--YWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSY 96
            |.:|.  |.||......:|.  .|:..:......|...:.:.||.|.....::.|.:.:.|....
  Fly     4 RRIKCLRYLGTRYNSSHYVT--TPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYPEQDVRLCTGT 66

Human    97 YENVIK----AMLESIGVPLEKLKFIKGTDY--QLSKEYTLDVYRLSSV-------VTQHDSKKA 148
            .|:..|    |.|.  |||:.|        |  .:|:.|. :|:|.:|:       .|:...|:|
  Fly    67 DEHGTKIQQAASLH--GVPVAK--------YCDDISQRYR-EVFRSASIQQDDFIRTTEDRHKRA 120

Human   149 GAEVVKQVE---HPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALG--YSKRV 208
            .|...:.:.   |  :....|.|...:.:|....|:|. .:|:            |.|  ||..
  Fly   121 VANFWRTLHTRGH--IYSAAYSGWYCVSDETFLTDSQL-RLDE------------ATGTRYSLE- 169

Human   209 HLMNPMVPGLTGSKMSSSEEESKIDLLDR-KEDVKKKLK-KAFCEPGNVENNGVLSFIKHVLFPL 271
                      :|..:..:||.:.:..|.: ::||:..:| :|...|...|.         :|...
  Fly   170 ----------SGHPVEWTEETNYMFRLSQFQDDVRHWVKTEARVRPAKFEK---------ILLDT 215

Human   272 KSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVH-----PGDLKNSVEVALNKLLDPIREKFNTP 331
            .||                ...|:.....:..||     |.|...:|.|.|:.|::
  Fly   216 LSE----------------PLPDVSVSRPSNRVHWAIPVPDDDSQTVYVWLDALVN--------- 255

Human   332 ALKKLASAAYPD-------PSKQKPMAKGPAK-------------NSEPEEVIPSRLDIRV---- 372
               .|:|..|||       |..|:.:.|...|             ..||    |.:|.:..
  Fly   256 ---YLSSVGYPDEKFSAHWPPAQQVIGKDILKFHGIYWTAFLLAAGLEP----PGQLYVHSHWTV 313

Human   373 -GKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEEL--QDRLVVVLCNLKPQKMRGV 434
             |:.::..||...|.|        :|..:..:.||..|:.:|.:  .|.   ...::|.|::...
  Fly   314 DGQKMSKSKHNVVDPL--------QAAQQYTMEGLRYFLLREGVAHSDG---NYSHVKAQRILNS 367

Human   435 E---SQGMLLC-ASIEGIN-RQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQAD 494
            |   :.|.||. ||.:.:| .|:.|      |...||:           .:|.....|.::||..
  Fly   368 ELADTLGNLLSRASAKSLNPGQIYP------SPSAEHL-----------ADLLRSLDVAKRLQDS 415

Human   495 -FKISEECIAQWKQTNF 510
             .::||.|.:.::..:|
  Fly   416 LLQLSERCESHYECNHF 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YARS1	NP_003671.1	nt_trans	8..328	CDD:469580	64/320 (20%)
		'HIGH' region. /evidence=ECO:0000269|PubMed:14671330	44..52		1/7 (14%)
		'KMSKS' region. /evidence=ECO:0000269|PubMed:14671330	222..226		0/3 (0%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22291016	242..247		1/5 (20%)
		PLN02610	<327..528	CDD:215329	46/217 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..363		9/43 (21%)
MetRS-m	NP_650348.1	MetG	21..559	CDD:439913	105/520 (20%)