Protein Alignment YARS1 and TyrRS-m

DIOPT Version :10

• Sequence 1: NP_003671.1
• Gene: YARS1 / 8565
• HGNCID: 12840
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_611967.1
• Gene: TyrRS-m / 37965
• FlyBaseID: FBgn0035064
• Length: 464
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 42/214 - (19%)
• Similarity: 81/214 - (37%)
• Gaps: 70/214 - (32%)

Human    11 LHLITR--------------NLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIAD 61
            |||:.|              ||  :.|.|.:..:.::||:   :|..          :|:....:
  Fly   218 LHLLRRHNCCFQMGGSDQTGNL--MTGHELISRVERKREV---FGLT----------LPLVTTEE 267

Human    62 FLKAGCEVTILFADLHAYLD-NMKAPWELLELRVSYYENVIKAMLESIG-VPLEKLKFIKGTDYQ 124
            ..|.|..     |....:|| |..:|:.|.:..:...::.::.:|:... :||.:::       |
  Fly   268 GDKFGKS-----AGNAVWLDGNKTSPFALYQFFLRMPDSEVEKLLKLFTFIPLPQVE-------Q 320

Human   125 LSKEYTLDVYRLSSVVTQHDSKKA-------------GAEVVKQVEHPLLSGLLYPG-LQALDEE 175
            |.:|:|          .:.:.:||             |...:||.|.  ::..||.| ::.|.|.
  Fly   321 LMREHT----------KEPEKRKAQTLLAEDVTLLVHGESGLKQAER--VTNALYKGNVEGLAEL 373

Human   176 YL-KVDAQFGGIDQRKIFT 193
            .| ::...|.|.....:.|
  Fly   374 NLSEIQQTFQGATMVNLLT 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YARS1	NP_003671.1	nt_trans	8..328	CDD:469580	42/214 (20%)
		'HIGH' region. /evidence=ECO:0000269|PubMed:14671330	44..52		0/7 (0%)
		'KMSKS' region. /evidence=ECO:0000269|PubMed:14671330	222..226
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22291016	242..247
		PLN02610	<327..528	CDD:215329
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..363
TyrRS-m	NP_611967.1	TyrS	28..464	CDD:439932	42/214 (20%)