Protein Alignment LGR5 and Lgr3

DIOPT Version :10

• Sequence 1: NP_003658.1
• Gene: LGR5 / 8549
• HGNCID: 4504
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_733115.1
• Gene: Lgr3 / 43098
• FlyBaseID: FBgn0039354
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 946
• Identity: 200/946 - (21%)
• Similarity: 330/946 - (34%)
• Gaps: 307/946 - (32%)

Human     8 VLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRML-LRVDCSD------------LGLSE 59
            |||...|:..|:.|.....|    ..|.....|.|..:|. .|.||:|            .|..|
  Fly    17 VLLLAAVIFYLSLGPCPAAS----FACDNGTLCVPRRQMCDSRNDCADSSDENPVECGLLYGSKE 77

Human    60 LPSNLSVFTSYLDLSMNNISQLLPNP---------LPSLRFLEELRLAGNALTYIPKGA------ 109
            :..  .:..:.::.....:...:.|.         :|..:.| .|.:..:.:|| ||..
  Fly    78 IAD--KIVRNAIEKKQQRLISAVSNASGADSTTSMVPRNQSL-TLNMTCDIVTY-PKACQCGQGT 138

Human   110 --FTGLYS------------LKVLMLQNN-QLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFS 159
              :.|.|:            ..:::::|| .||   .....|...||.|.|..|:||.||...||
  Fly   139 ILYCGRYAKLRRFPRLSSEVTNLIIIRNNLTLR---DNIFANFTRLQKLTLKYNNISRVPLGSFS 200

Human   160 GLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHS 224
            ||..|..|.|..|.::.:|...|..|.:||.:.|..|.:||:|           |..|...|
  Fly   201 GLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLHHLP-----------VEQLRFFR--- 251

Human   225 LGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFY 289
                      .||.|.|:.|.|        ||.|::           :|:     .|:|..::..
  Fly   252 ----------RLEWLVLSRNRL--------TLRNVQ-----------LPK-----IPTLYEVYLD 282

Human   290 DNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354
            .|.|:::|...|                                               :||.||
  Fly   283 FNRIEYIGEETF-----------------------------------------------SQLDNL 300

Human   355 QVLDLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNA 417
            .:|||.:||:..:  .:|:....::.|.|..|.|.|:..:||.....|.:|:||
  Fly   301 HLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKELSGETFLHNTRLEALSLA----------- 354

Human   418 FSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTG---NHA-LQSLISSENFPELKVIEMPYAYQ 478
                  |:.:.:||:|:.  |:    .::.|.|||   :|. .:::.|..|...:       .|.
  Fly   355 ------LMPIHISSSLME--PL----NISFLNLTGIRYDHIDFEAINSMRNLTYI-------IYD 400

Human   479 CCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSP 543
              .|..|....::.                                               .|.|
  Fly   401 --RFFYCSMTPRVR-----------------------------------------------MCKP 416

Human   544 SPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYIS---PIKLLIGVIAAVNML 605
            |.......:.||...::|...|.:|.|.:..|.||....|   :|..   .:.::|..:|..:||
  Fly   417 STDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRF---IYRDENVAVTMVIRNLALADML 478

Human   606 TGVSSAVLAGVDAFTF-GSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYS 669
            .|. ..|..||..:.: ..:.:....|.....|.:||.|::.:||.|:.:|...:|||...:
  Fly   479 MGF-YLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLERFLLI--- 539

Human   670 AKFETKAPFSSLKVI-------ILLCALL---ALTMAAVPLLGGSK---YGA-SPLCLPLPFGEP 720
                 ..||...:.|       .|:|..:   .|.:|.|.|...|.   ||: |..|.||...|.
  Fly   540 -----ADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEA 599

Human   721 STMGYMVALIL---LNSLCFLMMTIAYTKLYCNLDKGDLENIW-----------DCSMVKHIALL 771
            ..||::.:..:   :|.|..:|:.:.||.|        |.:||           ||........:
  Fly   600 FPMGWLYSAFVFLGVNLLLLVMIAMLYTAL--------LISIWRTRSATPLTLLDCEFAVRFFFI 656

Human   772 LFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL----- 831
            :.|:.:...|:..:......|.. ||.::..::::.|:||.:.:|||||....|.::..:
  Fly   657 VLTDFLCWVPIIVMKIWVFFNYN-ISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGW 720

Human   832 --VSLRKQ----------TYVWT---RSKHPSLMSI 852
              ::.||:          |...|   .|:||...:|
  Fly   721 KKITSRKRAEAGNGNVATTTTGTATGSSQHPDDFTI 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LGR5	NP_003658.1	LRRNT	33..65	CDD:396168	10/44 (23%)
		leucine-rich repeat	68..91	CDD:275380	2/31 (6%)
		LRR	92..477	CDD:443914	92/411 (22%)
		leucine-rich repeat	92..115	CDD:275380	7/30 (23%)
		leucine-rich repeat	116..139	CDD:275380	5/23 (22%)
		leucine-rich repeat	140..163	CDD:275380	13/22 (59%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	3/22 (14%)
		leucine-rich repeat	236..258	CDD:275380	8/21 (38%)
		leucine-rich repeat	259..282	CDD:275380	1/22 (5%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		leucine-rich repeat	307..353	CDD:275378	2/45 (4%)
		leucine-rich repeat	354..375	CDD:275378	7/22 (32%)
		leucine-rich repeat	376..389	CDD:275378	4/12 (33%)
		leucine-rich repeat	400..423	CDD:275378	4/22 (18%)
		leucine-rich repeat	445..459	CDD:275378	5/17 (29%)
		7tmA_LGR5	558..831	CDD:320485	73/304 (24%)
		TM helix 1	559..585	CDD:320485	8/25 (32%)
		TM helix 2	592..617	CDD:320485	7/24 (29%)
		TM helix 3	637..667	CDD:320485	11/29 (38%)
		TM helix 4	679..701	CDD:320485	6/31 (19%)
		TM helix 5	721..750	CDD:320485	8/31 (26%)
		TM helix 6	759..789	CDD:320485	6/40 (15%)
		TM helix 7	799..824	CDD:320485	8/24 (33%)
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060	9/36 (25%)
		LRR	85..389	CDD:443914	92/426 (22%)
		leucine-rich repeat	181..204	CDD:275380	13/22 (59%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/46 (22%)
		leucine-rich repeat	253..275	CDD:275380	10/45 (22%)
		leucine-rich repeat	276..299	CDD:275380	7/69 (10%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..347	CDD:275380	7/22 (32%)
		7tmA_Relaxin_R	431..715	CDD:320265	73/304 (24%)
		TM helix 1	432..458	CDD:320265	8/28 (29%)
		TM helix 2	465..490	CDD:320265	8/25 (32%)
		TM helix 3	510..540	CDD:320265	11/37 (30%)
		TM helix 4	552..574	CDD:320265	4/21 (19%)
		TM helix 5	603..632	CDD:320265	8/36 (22%)
		TM helix 6	644..674	CDD:320265	4/29 (14%)
		TM helix 7	683..708	CDD:320265	8/24 (33%)