Protein Alignment LGR5 and kek3

DIOPT Version :10

• Sequence 1: NP_003658.1
• Gene: LGR5 / 8549
• HGNCID: 4504
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_523575.1
• Gene: kek3 / 34912
• FlyBaseID: FBgn0028370
• Length: 1021
• Species: Drosophila melanogaster
• Alignment Length: 212
• Identity: 73/212 - (34%)
• Similarity: 103/212 - (48%)
• Gaps: 13/212 - (6%)

Human    10 LSLPVLLQLATGGSSPRSGVLLRGCPTHCHCE-PDGRMLLRVDCSDLGLSELPSNLSVFTSYLDL 73
            |.|.:||.|....|  :.|.|...||..|.|: ..|:.  .|.|.:..|:.:|..|...|..|||
  Fly    57 LHLHLLLWLLCCCS--QLGQLRAECPAVCECKWKSGKE--SVLCLNANLTHIPQPLDAGTQLLDL 117

Human    74 SMNNISQLLPN---PLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
            |.|.| ||:|:   ....|..|:::.||...|..|.:.||..|.:|..|.|..|.|..:|:.||.
  Fly   118 SGNEI-QLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALY 181

Human   136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSL-SALQAMTLALNKIH 199
            ::..|:.|||..|.|..||...|..:..|..|.|.|..|:.|.|:||..| |:|:.:.|..|::.
  Fly   182 HVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLS 246

Human   200 HIPDYAFGNLSSLVVLH 216
            .:..   |.::||..||
  Fly   247 EVRS---GTITSLASLH 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LGR5	NP_003658.1	LRRNT	33..65	CDD:396168	9/32 (28%)
		leucine-rich repeat	68..91	CDD:275380	11/25 (44%)
		LRR	92..477	CDD:443914	44/126 (35%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	8/22 (36%)
		leucine-rich repeat	140..163	CDD:275380	9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	10/23 (43%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	3/5 (60%)
		leucine-rich repeat	236..258	CDD:275380
		leucine-rich repeat	259..282	CDD:275380
		leucine-rich repeat	283..304	CDD:275380
		leucine-rich repeat	307..353	CDD:275378
		leucine-rich repeat	354..375	CDD:275378
		leucine-rich repeat	376..389	CDD:275378
		leucine-rich repeat	400..423	CDD:275378
		leucine-rich repeat	445..459	CDD:275378
		7tmA_LGR5	558..831	CDD:320485
		TM helix 1	559..585	CDD:320485
		TM helix 2	592..617	CDD:320485
		TM helix 3	637..667	CDD:320485
		TM helix 4	679..701	CDD:320485
		TM helix 5	721..750	CDD:320485
		TM helix 6	759..789	CDD:320485
		TM helix 7	799..824	CDD:320485
kek3	NP_523575.1	LRR	<98..>267	CDD:443914	58/167 (35%)
		leucine-rich repeat	112..137	CDD:275380	11/25 (44%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	10/23 (43%)
		leucine-rich repeat	235..258	CDD:275380	6/25 (24%)
		LRRCT	267..316	CDD:214507
		Ig	331..428	CDD:472250
		Ig strand B	335..339	CDD:409562
		Ig strand C	348..352	CDD:409562
		Ig strand E	394..398	CDD:409562
		Ig strand F	408..413	CDD:409562
		Ig strand G	421..424	CDD:409562