DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LGR5 and CG18095

DIOPT Version :10

Sequence 1:NP_003658.1 Gene:LGR5 / 8549 HGNCID:4504 Length:907 Species:Homo sapiens
Sequence 2:NP_001188805.1 Gene:CG18095 / 34823 FlyBaseID:FBgn0028872 Length:564 Species:Drosophila melanogaster


Alignment Length:562 Identity:139/562 - (24%)
Similarity:234/562 - (41%) Gaps:86/562 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    60 LPSN--LSVFT-----SYLDLS-MNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSL 116
            ||.:  |.:|:     |.|.|| .||....|   :.....|..|.|:...|.::..|.|.....|
  Fly     4 LPGSLLLLIFSFSPRLSCLQLSKCNNTEVTL---IRKTELLTSLTLSNCTLPHVENGFFVRFDHL 65

Human   117 KVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQA 181
            ..|.||::.|..:...:|..|..||.|.|..|::|.:.......|.:|.:|.|..|.|:::.|::
  Fly    66 LHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKS 130

Human   182 FRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
            |.....||.:.|..|:|..|.:.:|..||.|..|:|:.|::..:....|.|||.|.:|.|.:|.:
  Fly   131 FEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRI 195

Human   247 DEF--PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
             ||  ..:..:.::|:.|....|.:.|:...:..|...|:.::...|.:|.:....|....||:.
  Fly   196 -EFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQD 259

Human   310 LTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--F 370
            |.|  |..:::.: ..|:|..:||.|.::...:..:.....:.|..|..||:|:|||..||.  |
  Fly   260 LDLSYNNITKLNK-EALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLF 323

Human   371 SVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA------IIHP--NAFSTLPSLIKL 427
            ....:|::|.|.:|:|.||..........||.:.|:.|.|:      .:.|  |.|:     :.:
  Fly   324 HFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFT-----LYV 383

Human   428 DLSSNLLSSFPITGLHGLTHLKLTGN---------HALQSLISSENFPELKVIEMPYAYQCCAFG 483
            |||||.|.|..::.|....::.|..|         :.:|.|.:|.||                  
  Fly   384 DLSSNRLKSLNLSSLLHFRYINLADNNWSCNWLVANLVQKLPNSVNF------------------ 430

Human   484 VCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQC------- 541
                    :..|...:|.|.:..:.:.....:....|.:  .|||. ..:....|..|       
  Fly   431 --------ARPWTVINNLSENTTNVEGIDCIEGGTNRSI--ILLDV-SGVPQPKSDNCDCVVAYD 484

Human   542 --SPSPGPFK----PCEHLLDGWLIRIGVWTIAVLALTCNAL 577
              :|||.|..    |.:......:|   :|.:..:|:..:.|
  Fly   485 ETNPSPPPLTWPKIPTDRFDSRSVI---IWMLVAIAIAFSGL 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR5NP_003658.1 LRRNT 33..65 CDD:396168 2/6 (33%)
leucine-rich repeat 68..91 CDD:275380 7/28 (25%)
LRR 92..477 CDD:443914 110/407 (27%)
leucine-rich repeat 92..115 CDD:275380 6/22 (27%)
leucine-rich repeat 116..139 CDD:275380 7/22 (32%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
leucine-rich repeat 164..187 CDD:275380 7/22 (32%)
leucine-rich repeat 188..211 CDD:275380 8/22 (36%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..258 CDD:275380 6/23 (26%)
leucine-rich repeat 259..282 CDD:275380 5/22 (23%)
leucine-rich repeat 283..304 CDD:275380 4/20 (20%)
leucine-rich repeat 307..353 CDD:275378 10/47 (21%)
leucine-rich repeat 354..375 CDD:275378 10/22 (45%)
leucine-rich repeat 376..389 CDD:275378 5/12 (42%)
leucine-rich repeat 400..423 CDD:275378 8/30 (27%)
leucine-rich repeat 445..459 CDD:275378 3/22 (14%)
7tmA_LGR5 558..831 CDD:320485 4/20 (20%)
TM helix 1 559..585 CDD:320485 4/19 (21%)
TM helix 2 592..617 CDD:320485
TM helix 3 637..667 CDD:320485
TM helix 4 679..701 CDD:320485
TM helix 5 721..750 CDD:320485
TM helix 6 759..789 CDD:320485
TM helix 7 799..824 CDD:320485
CG18095NP_001188805.1 LRR 22..>338 CDD:443914 89/320 (28%)
leucine-rich repeat 41..64 CDD:275380 6/22 (27%)
leucine-rich repeat 65..88 CDD:275380 7/22 (32%)
leucine-rich repeat 89..112 CDD:275380 7/22 (32%)
leucine-rich repeat 113..136 CDD:275380 7/22 (32%)
leucine-rich repeat 137..160 CDD:275380 8/22 (36%)
leucine-rich repeat 161..184 CDD:275380 7/22 (32%)
leucine-rich repeat 185..208 CDD:275380 6/23 (26%)
leucine-rich repeat 209..232 CDD:275380 5/22 (23%)
leucine-rich repeat 233..256 CDD:275380 4/22 (18%)
leucine-rich repeat 257..280 CDD:275380 6/23 (26%)
leucine-rich repeat 281..304 CDD:275380 4/22 (18%)
leucine-rich repeat 305..328 CDD:275380 10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

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