Protein Alignment LGR5 and rk

DIOPT Version :10

• Sequence 1: NP_003658.1
• Gene: LGR5 / 8549
• HGNCID: 4504
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Alignment Length: 984
• Identity: 283/984 - (28%)
• Similarity: 434/984 - (44%)
• Gaps: 134/984 - (13%)

Human    17 QLAT--------GGSSPRSGVLLRGCPTHCHCEPDGRM-LLRVDCSDLGLSELPSNLSVFTSYLD 72
            ||:|        .|......:..|....||||  .|.: :||:.|..:|:..:|.||......||
  Fly   123 QLSTASTATDVIAGKRTLHSICERWLQKHCHC--TGSLEVLRLSCRGIGILAVPVNLPNEVVVLD 185

Human    73 LSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNL 137
            |..||:::|..|.......||||.|:.|::..:...||.||..||.|.|||..|:.:|.::.|.|
  Fly   186 LGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGL 250

Human   138 RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
            ..|.||:|:.|.:..:...|...|..||.|.|:.|....||..|...|..|:|:.|..|.:..|.
  Fly   251 AQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIN 315

Human   203 DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSN 267
            |..|..:.:|:||.|..|:|..:.......|.:|:.|:|:.|.:...|..:..||.|:||...||
  Fly   316 DEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSN 380

Human   268 NIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLES 332
            .:|.|.:.....:..::.:.  .||:..:...||:.:.:||.|.|:....:..||:|.....||.
  Fly   381 RLRWINDTELPRSMQMLDMR--ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEI 443

Human   333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIK------- 390
            |.|..|.|..:|..:|.|.|.|:.|:|..|.|:.:|:.|.|:.|:.:||..|:|.:|:
  Fly   444 LKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGL 508

Human   391 -----------------VDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
                             .|.||.:..|:.|:|..|:|:.||..|||...:|..|:|.:|:....|
  Fly   509 KQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP 573

Human   439 ITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAF--------------------- 482
            .:||..|.|||...|..|:.....:.||.::.:.:.|||.||||
  Fly   574 ESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLF 638

Human   483 ----------------GVCENAYKISNQ--------WNKGDNSSMDDLHKKDAG------MFQAQ 517
                            .:....:.:|.|        |....|.:.:.|..:..|      |.:..
  Fly   639 PSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYF 703

Human   518 DERDL-------------------EDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIG 563
            :|.|:                   |||         ...||||.|.||||.||..|.|.|.:|.|
  Fly   704 EEHDVSGPATGYGFGTGLFSGMSTEDF---------QPGSVQCLPMPGPFLPCADLFDWWTLRCG 759

Human   564 VWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHG 628
            ||.:.:|:|..|..|...:..|...:...:.|:..:||.:...|:...:||.|||.|.|.|....
  Fly   760 VWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFA 824

Human   629 AWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLAL 693
            ..|:..|.|.:.|||::.:||.||:.|.:..|||.:::.::.....:........|:.:..:.||
  Fly   825 IPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFAL 889

Human   694 TMAAVPLLGGSKYGASPLCLPLPFGE-PSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLE 757
            .||.:||:|.|.|....:|||..... |:::.|:::|:.:|...||.:...|.|:|..:......
  Fly   890 IMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAW 954

Human   758 NIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYIL 822
            |..|..:.|.:|||:||:.:...|:||.|.:::..|..||.|..|...:.|:||.:|.||.||.:
  Fly   955 NTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAI 1019

Human   823 FNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPS 887
            ....||:|.|:|         .||     .....|........:..|..|...   ||||..:|:
  Fly  1020 MTKQFKKDCVTL---------CKH-----FEESRVVGGGGPGGRGAVARTKRG---DLPPPLLPA 1067

Human   888 PAYPVTESC 896
            .|......|
  Fly  1068 AAVAHPPGC 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LGR5	NP_003658.1	LRRNT	33..65	CDD:396168	11/32 (34%)
		leucine-rich repeat	68..91	CDD:275380	7/22 (32%)
		LRR	92..477	CDD:443914	128/408 (31%)
		leucine-rich repeat	92..115	CDD:275380	10/22 (45%)
		leucine-rich repeat	116..139	CDD:275380	10/22 (45%)
		leucine-rich repeat	140..163	CDD:275380	7/22 (32%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..258	CDD:275380	6/21 (29%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		leucine-rich repeat	307..353	CDD:275378	16/45 (36%)
		leucine-rich repeat	354..375	CDD:275378	8/20 (40%)
		leucine-rich repeat	376..389	CDD:275378	5/12 (42%)
		leucine-rich repeat	400..423	CDD:275378	10/22 (45%)
		leucine-rich repeat	445..459	CDD:275378	6/13 (46%)
		7tmA_LGR5	558..831	CDD:320485	85/273 (31%)
		TM helix 1	559..585	CDD:320485	8/25 (32%)
		TM helix 2	592..617	CDD:320485	6/24 (25%)
		TM helix 3	637..667	CDD:320485	12/29 (41%)
		TM helix 4	679..701	CDD:320485	6/21 (29%)
		TM helix 5	721..750	CDD:320485	8/28 (29%)
		TM helix 6	759..789	CDD:320485	11/29 (38%)
		TM helix 7	799..824	CDD:320485	10/24 (42%)
rk	NP_476702.1	LRR	<157..390	CDD:443914	78/232 (34%)
		leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR	292..612	CDD:443914	94/321 (29%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..486	CDD:275380	25/67 (37%)
		leucine-rich repeat	441..464	CDD:275378	9/22 (41%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tmA_Glyco_hormone_R	754..1028	CDD:320264	85/273 (31%)
		TM helix 1	755..781	CDD:320264	8/25 (32%)
		TM helix 2	788..813	CDD:320264	6/24 (25%)
		TM helix 3	833..863	CDD:320264	12/29 (41%)
		TM helix 4	875..897	CDD:320264	6/21 (29%)
		TM helix 5	918..947	CDD:320264	8/28 (29%)
		TM helix 6	956..986	CDD:320264	11/29 (38%)
		TM helix 7	996..1021	CDD:320264	10/24 (42%)