DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG8925

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	155/548 - (28%)
Similarity:	240/548 - (43%)	Gaps:	75/548 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    15 HFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHV-------------CRPPGNVSQVVFHNH 66
            |....:|:|..:..:|::.|.   |.|:|..:...|:             |..|.|:.|:.....
  Fly   146 HTKLLERLLGCLTPWQSMWCA---LLSIFQAICTFHIFVYVFQIAPKDFWCARPENLMQMSVSEW 207

Human    67 SNWSLEDTGALLSSGQKDYVTVQLQNGEI--WELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGY 129
            .|.|....|.||.  ..||..|..:|.::  |.         ||.:.|||.... ..||..|||.
  Fly   208 RNISQSSNGCLLL--DVDYTQVTYENNQLINWP---------ENATDLGYRQCW-HFEFSDVDGS 260

Human   130 IYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFL 194
                   ..|.|.:::|||.|..|: |::..|:.|...|:|..|:.|||.|||..|.|..:...:
  Fly   261 -------AKTLVQEFDLVCGRDILS-LVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSV 317

Human   195 FGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVAL 259
            ||...||:.....||:.|..:...:....||.||.|:|.:..|.||...:......|:..:|.|.
  Fly   318 FGGILAFSTSVAMFMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAG 382

Human   260 TGYLVRTWWLYQMILSTVTVPFI--LCCWV-LPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCK 321
            ..||:|.|...|:.:|.   |::  |..|. |||:|.|||::||.:|...:::..|:.|..|:..
  Fly   383 LAYLIRDWRHLQLAISW---PWLIMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSASL 444

Human   322 LS------------------------ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTV 362
            .|                        |..:::...|..::...|....:.:....|..|..||.:
  Fly   445 PSNYRKTLEAAVPRAVQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWRTTCLTLVI 509

Human   363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVG-RRTVLAYSLFCSA 426
            ||   |..:.::..:|:..|||||.|:|..:.|.||..:.....:.:.||| ||:::.|.|. ..
  Fly   510 WL---TLIIIYFGLTLHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLL-PG 570

Human   427 LACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASIL 491
            |.|....::..:..::.:.|  :.|..|||...:|..|||..||||||:..||.|::...:|.||
  Fly   571 LCCLATNLVSNQTGVIALAT--IAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALIL 633

Human   492 APFSVDLSSIWIFIPQLFVGTMALLSGV 519
            .||...|..|...:|...:|...|:..|
  Fly   634 VPFLWKLEHIDPLLPLNVMGVCGLIGAV 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	155/548 (28%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG8925	NP_650526.1	MFS	277..667	CDD:119392	116/395 (29%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	108/367 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920