Protein Alignment SLC22A16 and CG6006

DIOPT Version :10

• Sequence 1: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001097812.1
• Gene: CG6006 / 41962
• FlyBaseID: FBgn0063649
• Length: 603
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 152/558 - (27%)
• Similarity: 263/558 - (47%)
• Gaps: 63/558 - (11%)

Human     9 IYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLED 73
            |.|.:||:|::|.::..:.:...:....|..:|::........|:.|..:..:......|
  Fly    85 IGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATWRN----- 144

Human    74 TGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTG--SKKEFPCVDGYIYDQ--- 133
                 .||..|       |...||....|:...|.|....::...  .||...| :.:.|:.
  Fly   145 -----LSGSVD-------NCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVAC-EKWEYETNDN 196

Human   134 --NTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFG 196
              |||.|    ||:|||:::.|..:.:..|:.||..|.:..||.||:.||:.:|:.::....:||
  Fly   197 VGNTWTS----QWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFG 257

Human   197 IAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTG 261
            :.......:..::..|..|.:|:......|.:..:|::..|.||.|.::......:..::::...
  Fly   258 LWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLA 322

Human   262 YLVRTWWLYQMILSTVTVPFILCC--W-VLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLS 323
            ||.:.   ||.:...:.:|.|..|  | |:||:|.|||.:||.:|.::|::..||:|       .
  Fly   323 YLTQD---YQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFN-------G 377

Human   324 ELLSLDLQ--GPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGN 386
            ..|..|.|  .|...|.|:    :::|||.:..:.:.::..:.||||.:|.:|...||..:.|||
  Fly   378 RQLPADYQLTPPTQESSTQ----DVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGN 438

Human   387 EYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKH---YILGVVTAM 448
            .|||..|.|:|||||.......:.|||::.:...:|.|:.:|| ....|.:.|   ..|.:...|
  Fly   439 VYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVAC-CCAAITEGHADLLWLKITFLM 502

Human   449 VGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTM 513
            :|||.|.|...::.:||||||||.:|::.||:.::...||.||.|:...|:.|...:....:...
  Fly   503 MGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAW 567

Human   514 ALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSS 551
            ::..|.:.|.||||           |.:.:::|:..||
  Fly   568 SIFGGFVVLFLPET-----------AVRQKTDNQGGSS 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	MFS_SLC22A16_CT2	118..525	CDD:340933	124/421 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		3/9 (33%)
CG6006	NP_001097812.1	MFS_SLC22	189..579	CDD:340875	121/408 (30%)