DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG6006

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	152/558 - (27%)
Similarity:	263/558 - (47%)	Gaps:	63/558 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     9 IYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLED 73
            |.|.:||:|::|.::..:.:...:....|..:|::........|:.|..:..:......|
  Fly    85 IGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATWRN----- 144

Human    74 TGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTG--SKKEFPCVDGYIYDQ--- 133
                 .||..|       |...||....|:...|.|....::...  .||...| :.:.|:.
  Fly   145 -----LSGSVD-------NCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVAC-EKWEYETNDN 196

Human   134 --NTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFG 196
              |||.|    ||:|||:::.|..:.:..|:.||..|.:..||.||:.||:.:|:.::....:||
  Fly   197 VGNTWTS----QWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFG 257

Human   197 IAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTG 261
            :.......:..::..|..|.:|:......|.:..:|::..|.||.|.::......:..::::...
  Fly   258 LWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLA 322

Human   262 YLVRTWWLYQMILSTVTVPFILCC--W-VLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLS 323
            ||.:.   ||.:...:.:|.|..|  | |:||:|.|||.:||.:|.::|::..||:|       .
  Fly   323 YLTQD---YQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFN-------G 377

Human   324 ELLSLDLQ--GPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGN 386
            ..|..|.|  .|...|.|:    :::|||.:..:.:.::..:.||||.:|.:|...||..:.|||
  Fly   378 RQLPADYQLTPPTQESSTQ----DVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGN 438

Human   387 EYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKH---YILGVVTAM 448
            .|||..|.|:|||||.......:.|||::.:...:|.|:.:|| ....|.:.|   ..|.:...|
  Fly   439 VYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVAC-CCAAITEGHADLLWLKITFLM 502

Human   449 VGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTM 513
            :|||.|.|...::.:||||||||.:|::.||:.::...||.||.|:...|:.|...:....:...
  Fly   503 MGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAW 567

Human   514 ALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSS 551
            ::..|.:.|.||||           |.:.:::|:..||
  Fly   568 SIFGGFVVLFLPET-----------AVRQKTDNQGGSS 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	146/535 (27%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577		3/9 (33%)
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	144/527 (27%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	110/371 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920