DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG14857

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	134/561 - (23%)
Similarity:	224/561 - (39%)	Gaps:	85/561 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNH-SNW 69
            |:.|.:..|..||:|.::..:..:...:..:||.:...:|..|.|.|          :|.. .|.
  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWC----------YHEALENR 57

Human    70 SLEDTGAL------------LSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKE 122
            |.|:..|:            |...:.|.|||..:..:.|.
  Fly    58 SFEEIAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQRWI------------------------- 97

Human   123 FPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGR-RVVLW 186
                  |.||.......|...|  ||:..:.|.:.|.||..|.|:|:.|||...||:|| |.|:.
  Fly    98 ------YNYDFGFRSMNAELNW--VCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVIL 154

Human   187 ATSSSMFLFGIAAAFAVDYYTFMAARFF--LAMVASGYLVVGFVYVMEFIGMKSRTWA-SVHLHS 248
            |.... |:......:|.:...|...|..  ||..|:.||:  |:.|:|::..|.|..| |..|..
  Fly   155 ANQCG-FVGDFLTTYASNLVQFAIFRCISGLAATANYYLM--FILVLEYLAPKLRNMAISGTLGI 216

Human   249 FFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAK 313
            .|.:|.|:......|...|.:|....:.:.:...|..:|:.|:..||::....|.|...:..:|.
  Fly   217 CFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAH 281

Human   314 WNRASSCKLSELLSLDLQG---------PVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTG 369
            :|.      .|:.:.|.:.         .:||.|.  |...:..|....::.|.:|.|...:...
  Fly   282 FNG------MEVKAADFEAFRRNCIVKRKLSNQPE--QTAGIFDLLRTPNLRKVSLLVVFTFMLT 338

Human   370 SLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSAL---ACGV 431
            ||.|.:.|.|...:|.:.::...|..||..|:.....:...:|||:.....::.|:.|   |.||
  Fly   339 SLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGV 403

Human   432 VMVI--PQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPF 494
            .:..  .||:..|.:..|:..:..|...:.:...:.:||.||.|||..:.:..:....||.::|:
  Fly   404 ALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPY 468

Human   495 SVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATT 535
            .:.|.:.....|.|.:..:.|.:...||.||||..::|..|
  Fly   469 LIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPIT 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	131/551 (24%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	131/551 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	90/354 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850