Protein Alignment SLC22A16 and SLC22A

DIOPT Version :10

• Sequence 1: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 572
• Identity: 157/572 - (27%)
• Similarity: 255/572 - (44%)
• Gaps: 66/572 - (11%)

Human     7 EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCR------PPGNVSQVVFHN 65
            :.|..|:|.|||||.:::.:.....:...:..:..||...|..|.|.      |..|    .:..
  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSN----YYEP 88

Human    66 HSNWSLEDTGALLSSGQKDYVTVQLQNGEIW--ELSRCSRNKRENTSSLGYEYTGSKKEFPCVDG 128
            |:|||:...|..|.|..: |...:|..   |  .:..||.:          .:|.:|:  .|.
  Fly    89 HTNWSIPKNGKDLDSCNR-YTNSELPQ---WNHSVDICSAD----------HFTKNKE--ACA-- 135

Human   129 YIYDQNTWKSTAVT---QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSS 190
              :::..::...||   .:.:.||.:|...::..:...|...|....|:.:||.||       |.
  Fly   136 --HNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGR-------SF 191

Human   191 SMFLFGIAAA-------FAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHS 248
            |:.|.||..|       |:..|..|:...|...|.:|......||..:|.:|.|.|..|...:..
  Fly   192 SIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITV 256

Human   249 FFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAK 313
            |:|||.:|:|::......|.:...|....::..:...|:|||:..||||:|:.|.|:.|:
  Fly   257 FYAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNIL----- 316

Human   314 WNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLS-------YLFYNWSITKRTLTVWLIWFTGSL 371
             .||:.....||....|...|..:..::|:.:.|       :..:.|.|...:    |.|....|
  Fly   317 -RRAAHVNKRELPESVLDKLVLANRDKLQQSSESRFPIREAFKNFKWRIANCS----LCWIVHVL 376

Human   372 GFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIP 436
            .:|..|||.|.|.|::|.|...:.:||||.:....:.||:.|||..|...:..|.|.|...:...
  Fly   377 VYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTG 441

Human   437 QKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSI 501
            ....:|.:|..:|||..|.|:|.::|.:.:|:|||.:|:..:...||:.|..|:|||.:..|:..
  Fly   442 ADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKY 506

Human   502 WIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKL 553
            :...|.:.....|::||:|||..|||....|.||.:||..:..:.:|||..|
  Fly   507 YANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	MFS_SLC22A16_CT2	118..525	CDD:340933	117/423 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		4/11 (36%)
SLC22A	NP_649370.1	MFS_SLC22	136..530	CDD:340875	115/410 (28%)