Protein Alignment H2BC21 and His2B:CG33884

DIOPT Version :10

• Sequence 1: NP_003519.1
• Gene: H2BC21 / 8349
• HGNCID: 4760
• Length: 126
• Species: Homo sapiens
• Sequence 2: NP_001027345.1
• Gene: His2B:CG33884 / 3772575
• FlyBaseID: FBgn0053884
• Length: 123
• Species: Drosophila melanogaster
• Alignment Length: 756
• Identity: 136/756 - (17%)
• Similarity: 243/756 - (32%)
• Gaps: 232/756 - (30%)

Human   340 WKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKK 404
            ||:::...:::|::   .::...|..|.:...|..::....||                 ..|::
  Fly   200 WKKVEKRFESLSKN---GLLARDDFGECVGMVDSKDFAVSVFD-----------------ALARR 244

Human   405 RKEVLPKMMA-----FCYQILTDPNFDPR----------KKDGALHVIGSLAEILL------KKS 448
            |::.|.|:..     |..|| :|.:||.|          .:||.: ....:.|:|:      |.:
  Fly   245 RRQKLEKITKDELHDFWLQI-SDQSFDARLQIFFDMADSNEDGKI-TREEIKELLMLSASANKLA 307

Human   449 LFKDQIELFLQNHVFPLLMSNLGYLRARSCWVLHAF--------------------SSLKFHNEL 493
            ..|:|.|.:....:..|...|.||:   ..|.|...                    .|....|.:
  Fly   308 KLKEQAEEYASLIMEELDPENFGYI---ELWQLETLLLQRDAYMNYSRPLSTTSGGVSTPRRNLI 369

Human   494 NLRNAVELAKKS---LIED---------------------EEMPVKVEAALALQSLISNQAQ-AK 533
            ..|:.|:..:|.   ||.|                     :.:..:.:||..:.......|: |.
  Fly   370 RPRHVVQKCRKKLQCLILDNWQRSWVLLVWVMLMAILFVWKFLEYREKAAFKVMGYCLTTAKGAA 434

Human   534 EHMKPYVRFIMQELLHIVRETEN-------------DDVTNVIQKLICEYSQDVASIAVDTTQHL 585
            |.:|..:..:   ||.:.|.|..             ||..|..:.:.|..:   ..|.|....||
  Fly   435 ETLKLNMALV---LLPVCRNTLTWLRSTRARACVPFDDNINFHKIIACAIA---IGILVHAGTHL 493

Human   586 AEIFGKVLQSDEYEEIEDKTVMAM---GILHTIDTILTVVEDHPEIIQQLENICLRIIDLVLQKH 647
            |..|.:::.|..    |...::|.   |...|...::|..|.    |..:..:.|..|...|..
  Fly   494 ACDFPRIINSSP----EQFVLIASAFNGTKPTFKDLMTGAEG----ITGISMVILTTIAFTLAS- 549

Human   648 VIEFYEEILSLAYNLTCHTISPQMW---QLLGILY-EVFQQDCFEYFTDMMPLLHNYVTVDTNAL 708
             ..|....:.|...|...|.....|   .||.::| .:.....|.:|.|      .:....|...
  Fly   550 -THFRRNRVRLPAPLDRLTGFNAFWYTHHLLVVVYIMLIVHGTFLFFAD------KWYQKTTWMY 607

Human   709 LSNPKHLEVL---FTMCRKVLCGEAGEDAECYAAKLLEVIILQCKGRGIDQCIPLFIQLVLERLT 770
            :|.|..|.|.   ...||          ::.|:.|:|:|.:|
  Fly   608 ISVPLVLYVAERSLRACR----------SKHYSVKILKVSML----------------------- 639

Human   771 RGVKTSELRTMCLQVAIAALYYSPELLFHTLEQVQLP------HNPGPVTS-----------QFI 818
                ..|:.::.:.......|.|.:.:|     :|.|      .:|..:||           :.:
  Fly   640 ----PGEVLSLIMSKPPGFKYKSGQYIF-----LQCPTISRFEWHPFSITSAPGDDQLSVHIRTL 695

Human   819 NQWMNDTDYFLG-HHDRKMCIIGLSVL-----LELQNRP----------PAVDAVAAQILPSILF 867
            ..|..:....|. ..|...|:||.|..     :::.|||          ||.|..:..:|   |.
  Fly   696 GDWTEELRRVLTVGKDLSTCVIGRSKFSAYCNIDMINRPKLLVDGPYGAPAQDYRSYDVL---LL 757

Human   868 LFLGLKQVCATRQTVNRENHSKAEKVDIE-ENEEISSEEEEETSVSAQAMQSQIGR--------- 922
            :.||:..........:..|:|:.|:.|.| ...:.|......:..:|....:..|:
  Fly   758 IGLGIGATPFISILKDLLNNSRDEQTDNEFSRSDFSWNSCTSSYTTATPTSTHGGKKKAVKAHFY 822

Human   923 --SEEEDDDDWDEEVLEETALEGFSTPLDLDNSVDEYQFFT 961
              :.|....:|...|:||.      :.:|....::.:.:.|
  Fly   823 WVTREPGSVEWFRGVMEEI------SDMDCRGQIELHNYLT 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
H2BC21	NP_003519.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		HFD_H2B	30..123	CDD:467035
His2B:CG33884	NP_001027345.1	HFD_H2B	33..120	CDD:467035