Protein Alignment CARS1 and CysRS

DIOPT Version :10

• Sequence 1: NP_001014437.1
• Gene: CARS1 / 833
• HGNCID: 1493
• Length: 831
• Species: Homo sapiens
• Sequence 2: NP_611087.1
• Gene: CysRS / 36784
• FlyBaseID: FBgn0027091
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 738
• Identity: 439/738 - (59%)
• Similarity: 530/738 - (71%)
• Gaps: 15/738 - (2%)

Human    95 RRVQPQWSPPAGTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDI 159
            :|.||.|..|......:|.|:|||||.||.|:|.||..||||.||||||||||||||||||||||
  Fly     3 KRGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFDI 67

Human   160 LRRVLKDYFKFDVFYCMNITDIDDKIIKRARQNHLFEQY---REKRPEAAQLLEDVQAALKPFSV 221
            |||:|.|||.:::.|.|||||||||||:||||||||::|   .:|.| ..:||...:..|:.|..
  Fly    68 LRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLP-LDELLGQQKEVLQRFQD 131

Human   222 KLNETTDPDKKQMLERIQHAVQLATEPLEKAVQSRLTGEEVNSCVEVLLEEAKDLLSDWLDSTLG 286
            ...:.||||||.||::....:..|.|.|.||| .:....|::....:.|.||||.:||||||..|
  Fly   132 TCAKNTDPDKKIMLDKTLQRMNDAVEALTKAV-GKGDEREISEKRLLYLNEAKDPISDWLDSLKG 195

Human   287 CDVTDNSIFSKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 351
            ..:.||::|..||::||..||.||::||:||||||||||||||:||.|:|||:|||..|.:|.||
  Fly   196 AQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYAANNSV 260

Human   352 YFDTAKFASSEKHSYGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSW 416
            |||...|...|||.|.||||||.||.|:||||||||||:.||||||||.||||||||||.|||.|
  Fly   261 YFDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKAGEPWW 325

Human   417 PCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTG 481
            ..|||||||||||||||||..:.|.:.|||.||.||:|||||||||||||.|....||:||||||
  Fly   326 DSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKYFLHTG 390

Human   482 HLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFF 546
            ||||||||||||||||:||::|||||||.|||||||:||||||||||.||||.|.||||||||||
  Fly   391 HLTIAGCKMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKDTLDYSENTMEMATQYEKFLNEFF 455

Human   547 LNVKDILRAPV--DITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCN 609
            |||||:.|..:  :...||:.|.|.||.|.|.|.:.:..:|.:||||:|||:.::.:|.|||..|
  Fly   456 LNVKDLTRHVLSEEPRRQFDAWTEVEAALQKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSN 520

Human   610 LYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVE-EDSSLGFPV-GGPGTSLS---LEATVMP 669
            :|:...|.   |.|..||.|:|.|:|.:|.:|||:. ....:|||| ||.|...:   ||.||:|
  Fly   521 VYIRDNKT---RLNSLLLRNVATYITDLLHVFGAISGPRGGIGFPVSGGSGAQAAGADLETTVLP 582

Human   670 YLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKER 734
            |:|.|:|||..||:.|:..|..:||:|.|.||||:||.||||.||.:.....||||||::||:||
  Fly   583 YVQSLAEFRYLVREQAKTLKAFDILKLCDDLRDNVLPNLGVRLEDKDIGKYAVKLVDRDSLLRER 647

Human   735 EEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKEL 799
            |.|...|.||..:||...:...|..|||.|:.::.|.||||:||:|||.||||||||||.||||:
  Fly   648 EAKLAAEAEKAAEKERKKQAAAEAAAAKEAQRRVNPKEMFLAETEKYSAFDENGLPTHDKEGKEV 712

Human   800 SKGQAKKLKKLFEAQEKLYKEYL 822
            ||||.|||:||.:.||:.|.|||
  Fly   713 SKGQIKKLQKLQQQQEQRYNEYL 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CARS1	NP_001014437.1	GST_C_CysRS_N	3..76	CDD:198343
		PTZ00399	91..822	CDD:240402	437/736 (59%)
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	439/738 (59%)