Protein Alignment LZTR1 and Lztr1

DIOPT Version :10

• Sequence 1: NP_006758.2
• Gene: LZTR1 / 8216
• HGNCID: 6742
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_001259114.1
• Gene: Lztr1 / 31037
• FlyBaseID: FBgn0040344
• Length: 998
• Species: Drosophila melanogaster
• Alignment Length: 839
• Identity: 428/839 - (51%)
• Similarity: 560/839 - (66%)
• Gaps: 75/839 - (8%)

Human     2 AGPGSTGGQIG--AAALA-----GGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPP 59
            :|||.:|..:.  ||:.|     .|:....:|.   .:||:    .|.::|..:...|:|.|:..
  Fly   186 SGPGGSGCSMAYDAASNASSGSGSGSGKATSPG---SYSCN----ALNVDFTSYTATHQWTRMLE 243

Human    60 CDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAV 124
            |.|||||:||||||||||||::||||||||.|||||:||.|||.||.||..||||||||||||||
  Fly   244 CAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPRYHHSAV 308

Human   125 VYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWI 189
            |.|||||:||||||||:|||||.||||||||||.:..|.|||..||.||.||||||.||.:|:||
  Fly   309 VAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMWI 373

Human   190 FAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNN 254
            :||||||||||||||:.|.....  ||||.|.|:.||:||||||||.||.|:|||||||.:|||:
  Fly   374 YAGYDGNARLNDMWTLNLTGENQ--WEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNS 436

Human   255 LFQFEFKDKTWTRIPTEHLLRG-SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDF 318
            ||:|.||.:||.||..|.:||| :..||.||||||||..||.||||||:||:||||:|||||:|.
  Fly   437 LFEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDS 501

Human   319 QTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASE 383
            |.|.|:||..:|:|
  Fly   502 QVWSVIQPEQNSDV--------------------------------------------------- 515

Human   384 LPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
             ||||:|||:|||.||||||||||||::|.|:.||||||.||||||.:|:|:.::.:||||::|:
  Fly   516 -PSGRVFHASAVICDAMYIFGGTVDNSVRRGDTYRFQFSSYPKCTLRDDFGKFFQDKQFCDIQFI 579

Human   449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQ--EAAPVPREAPGVAAGGARPPLLHV 511
            :|.:|..:..|:|.|.|||::||.||..|||...|::|:  ....|...|....|||.|.|:|.|
  Fly   580 VGAEEIRILAHIAFVAARSKYLRNKILAAREARQQQMEKVYGVGQVDALALNAGAGGDRGPMLEV 644

Human   512 AIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDL 576
            .:..|....||:::.::|||:|..........::||.|:|:||..|.:.||...|.||::..::.
  Fly   645 RLANASPEAFEIILNYIYTDRIDLKDTYSKNIIILITDIYQLAGLFTMPRLAHGCIQYLDYKINK 709

Human   577 QNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPL 641
            .|||....:|.:..:..:|:||:.|::||.:|..|:|..||..|..||:|||: ||:..|.:..:
  Fly   710 LNVLEALYNADKSNIKIIKDHCMQFIIKEENFTDVVMSSEFSDLDKPLLVEII-RKRLYPSKLVI 773

Human   642 DQPVD--IGTSLIQDMKAYLEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDG 704
            |...:  |||:|..|:.|:||..|.:||||:|:|:.|..||||::|::|.:||:.|||||||.|.
  Fly   774 DTSYEGNIGTTLEIDLCAFLESTGKDFCDISLVLEDHVIPAHKSVLSSRCTYFQGMFRSFMPPDN 838

Human   705 QVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVT 769
            .|||.|||:.||.:||.|:||||||||..|||:|:||||.||.:||..||||.|:||.:||.|:|
  Fly   839 TVNIQIGEISPSLEAFHSLLRYIYYGETKMPPQDALYLFQAPCFYGLANNRLHAFCKYSLEHNIT 903

Human   770 VQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLA-SH 827
            .:||||.|||:|.|:..|:|.:.|.:||..|.||::||.:..||::|||:||.::| ||
  Fly   904 FENVLQTLEASDITKIYDIKEYALKLIVKDFAKVARLPKIAGLSRELLLEIIRAVADSH 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LZTR1	NP_006758.2	NanM	54..420	CDD:442289	224/366 (61%)
		KELCH repeat	68..114	CDD:276965	36/45 (80%)
		Kelch 1. /evidence=ECO:0000255	79..128		38/48 (79%)
		KELCH repeat	118..172	CDD:276965	42/53 (79%)
		Kelch 2. /evidence=ECO:0000255	130..185		41/54 (76%)
		Kelch 3. /evidence=ECO:0000255	187..238		33/50 (66%)
		Kelch 4. /evidence=ECO:0000255	239..285		27/46 (59%)
		KELCH repeat	284..326	CDD:276965	30/41 (73%)
		Kelch 5. /evidence=ECO:0000255	295..341		25/45 (56%)
		Kelch 6. /evidence=ECO:0000255	399..450		32/50 (64%)
		BTB1_POZ_LZTR1	420..571	CDD:349617	61/152 (40%)
		BACK1_LZTR1	575..633	CDD:350580	22/57 (39%)
		BTB2_POZ_LZTR1	647..772	CDD:349618	74/124 (60%)
		BACK2_LZTR1	768..828	CDD:350581	30/61 (49%)
Lztr1	NP_001259114.1	NanM	252..551	CDD:442289	216/352 (61%)
		KELCH repeat	252..298	CDD:276965	36/45 (80%)
		KELCH repeat	302..355	CDD:276965	41/52 (79%)
		KELCH repeat	359..407	CDD:276965	32/49 (65%)
		KELCH repeat	410..455	CDD:276965	31/44 (70%)
		KELCH repeat	467..509	CDD:276965	30/41 (73%)
		BTB1_POZ_LZTR1	551..704	CDD:349617	61/152 (40%)
		BACK1_LZTR1	708..766	CDD:350580	23/58 (40%)
		BTB2_POZ_LZTR1	781..906	CDD:349618	74/124 (60%)
		BACK2_LZTR1	902..962	CDD:350581	28/59 (47%)