DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC38A1 and CG16700

DIOPT Version :9

Sequence 1:	NP_001265319.1	Gene:	SLC38A1 / 81539	HGNCID:	13447	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_573191.1	Gene:	CG16700 / 32694	FlyBaseID:	FBgn0030816	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	114/508 - (22%)
Similarity:	200/508 - (39%)	Gaps:	107/508 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     9 ELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSL 73
            :|.:.|..|||..:.....|...|.|  |...:|...:::...             ||.|.|:.|
  Fly     8 QLEKNQTATVPRQETAEGGSTGETAV--GGAAAKVTKEQDHDA-------------EYHPPTSYL 57

Human    74 GMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSK-------ETGC 131
             .::.:|....:|.|:..:..|..|.|:|:..:|...:.::||:..::|:.|||       ::.|
  Fly    58 -ETIVHLFKGNIGPGLFAMGDAFKNGGLLVAPLLTVVIAVVSIHCQHVLVTCSKKMRDLKGDSVC 121

Human   132 MVYEKLGEQVF-----------GTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEE 185
            ..|.:..||.|           .|.|:.|.......|.....:.::||..|           .::
  Fly   122 ADYAQTVEQCFENGPSKLRGWSRTMGRLVDIFICVTQLGFCCIYFVFISTN-----------LKQ 175

Human   186 TFSAWYVDGRV-LVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPE 249
            ...|:.:|..| ||:::.|..:|...|:.||.:|...|.|:..||:..|.:.:|  :.:...:||
  Fly   176 ILQAYDIDMNVHLVMLLAFVPVLLSSLITNLKWLTPVSMFANVCMILGLAITLY--YALKDGLPE 238

Human   250 LNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQM-VSNI 313
            :..  .|..||           .|:......|..|||.....|:|:.:.::...|.:..: |.|:
  Fly   239 VEE--RALWTN-----------GSQLALFFGTAIFAFEGIALVMPLKNAMRKPHQFERPLGVLNV 290

Human   314 SFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTV--- 375
            ..|.:.||:......||:.:.:.|...|  .....|.||...|:|.|...|:|..|:.||..
  Fly   291 GMFLVSVMFMFAGSVGYMKWGEQVGGSL--TLNLGDTILAQAVKLMVSAGVLLGYPLQFFVAIQI 353

Human   376 -------------RSSLFELAKKTKFNLCRHTVVTCILLVVINLLVI-FIPSMKDIFGVVGVTSA 426
                         ||.|.||..:|             .:|::.|.:. .:|::.....::|...:
  Fly   354 MWPNAKQMCGIEGRSLLGELGFRT-------------FMVLVTLAIAEMVPALGLFISLIGALCS 405

Human   427 NMLIFILPSSLYLKITDQDGDKGTQRIWLFLFLQFPVQPCWLSECIILLPAAL 479
            ..|..:.|..:.| |:..:.:|| ..||:          | :...:||:.|.|
  Fly   406 TALALVFPPVIEL-ISRSELNKG-PGIWI----------C-VKNLVILVLALL 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC38A1	NP_001265319.1	SLC5-6-like_sbd	69..480	CDD:382020	101/448 (23%)
CG16700	NP_573191.1	SLC5-6-like_sbd	53..452	CDD:294310	101/448 (23%)
CG16700	NP_573191.1	SdaC	57..452	CDD:223884	100/444 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D697331at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760