DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP4K2C and PIP4K

DIOPT Version :9

Sequence 1:	NP_001139730.1	Gene:	PIP4K2C / 79837	HGNCID:	23786	Length:	421	Species:	Homo sapiens
Sequence 2:	NP_001033805.1	Gene:	PIP4K / 3885565	FlyBaseID:	FBgn0039924	Length:	404	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	210/410 - (51%)
Similarity:	274/410 - (66%)	Gaps:	47/410 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    29 KKKHF--VQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHR 91
            |||||  ..||||:|||.:|::.||:||:.|:|||||.|..|||||||||:|.|||||:||||::
  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79

Human    92 ENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPP--SESEGSDG-RFLISYDRTLVIKE 153
            ||:|||||.|||||.||||||:|||:||.||..||||:.|  .:|.|..| :|..|||:..:||.
  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144

Human   154 VSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD 218
            ::||:|..||:.|..||.|:|:.||.|||||:|||||::|::...|.:||||:||..|.:|:|:|
  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209

Human   219 LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSL 283
            ||||.|.||||:||..|.|||.||.||:.:..|:.||:|.|...::.|..||:.|.:|.||||||
  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274

Human   284 LLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVG----------------SYGTSPEGI 332
            |:|:||.:|.   ||||        :.||..||     ||                :|.|.|:..
  Fly   275 LVGVHDCVRA---EEEA--------LQGDNILT-----VGRSENSESEECDSGERWTYNTPPDSP 323

Human   333 GGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAG 397
            .|..:.       |....:|:|.|.|.|  .::|:||:.:||:||||..||:||.||||||:|:.
  Fly   324 RGAQYK-------EVVYEVDIYDIPSIE--EKREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSN 379

Human   398 AE-ISTVHPEQYAKRFLDFI 416
            .: |||..|||||||||||:
  Fly   380 VDGISTCDPEQYAKRFLDFM 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K2C	NP_001139730.1	Required for interaction with PIP5K1A. /evidence=ECO:0000269\|PubMed:31091439	69..75		5/5 (100%)
PIP4K2C	NP_001139730.1	PIPKc	72..420	CDD:214623	182/365 (50%)
PIP4K	NP_001033805.1	PIPKc	32..403	CDD:295374	198/393 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1678
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1592
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52363
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0001219
OrthoInspector	1	1.000	-	-		otm41537
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X950
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.940