Protein Alignment PIP4K2C and PIP4K

DIOPT Version :10

• Sequence 1: NP_079055.3
• Gene: PIP4K2C / 79837
• HGNCID: 23786
• Length: 421
• Species: Homo sapiens
• Sequence 2: NP_001033805.1
• Gene: PIP4K / 3885565
• FlyBaseID: FBgn0039924
• Length: 404
• Species: Drosophila melanogaster
• Alignment Length: 410
• Identity: 210/410 - (51%)
• Similarity: 274/410 - (66%)
• Gaps: 47/410 - (11%)

Human    29 KKKHF--VQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHR 91
            |||||  ..||||:|||.:|::.||:||:.|:|||||.|..|||||||||:|.|||||:||||::
  Fly    15 KKKHFRVKHQKVKLFRANEPILSVFMWGINHTINELSHVNIPVMLLPDDFRAYSKIKVDNHLFNK 79

Human    92 ENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPP--SESEGSDG-RFLISYDRTLVIKE 153
            ||:|||||.|||||.||||||:|||:||.||..||||:.|  .:|.|..| :|..|||:..:||.
  Fly    80 ENMPSHFKVKEYCPLVFRNLRERFGVDDVDYRESLTRSQPIQIDSSGKSGAQFYQSYDKFFIIKS 144

Human   154 VSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD 218
            ::||:|..||:.|..||.|:|:.||.|||||:|||||::|::...|.:||||:||..|.:|:|:|
  Fly   145 LTSEEIERMHAFLKQYHPYVVERHGKTLLPQYLGMYRITVESVQYYFVVMRNVFSSHLTIHKKFD 209

Human   219 LKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSL 283
            ||||.|.||||:||..|.|||.||.||:.:..|:.||:|.|...::.|..||:.|.:|.||||||
  Fly   210 LKGSTVDREASEKELEKNLPTFKDNDFIKQKVKLDIGKEAKDKLMDTLSNDVDLLTKLHIMDYSL 274

Human   284 LLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVG----------------SYGTSPEGI 332
            |:|:||.:|.   ||||        :.||..||     ||                :|.|.|:..
  Fly   275 LVGVHDCVRA---EEEA--------LQGDNILT-----VGRSENSESEECDSGERWTYNTPPDSP 323

Human   333 GGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAG 397
            .|..:.       |....:|:|.|.|.|  .::|:||:.:||:||||..||:||.||||||:|:.
  Fly   324 RGAQYK-------EVVYEVDIYDIPSIE--EKREIYFIAIIDVLTQYGVKKQAAKAAKTVKYGSN 379

Human   398 AE-ISTVHPEQYAKRFLDFI 416
            .: |||..|||||||||||:
  Fly   380 VDGISTCDPEQYAKRFLDFM 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K2C	NP_079055.3	PIPKc_PIP5K2C	46..418	CDD:340448	198/391 (51%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000269|PubMed:31091439	69..75		5/5 (100%)
PIP4K	NP_001033805.1	PIPKc_PIP5KII	34..401	CDD:340442	198/391 (51%)