Protein Alignment PIP4K2C and PIP5K59B

DIOPT Version :10

• Sequence 1: NP_079055.3
• Gene: PIP4K2C / 79837
• HGNCID: 23786
• Length: 421
• Species: Homo sapiens
• Sequence 2: NP_001369113.1
• Gene: PIP5K59B / 37633
• FlyBaseID: FBgn0034789
• Length: 891
• Species: Drosophila melanogaster
• Alignment Length: 404
• Identity: 120/404 - (29%)
• Similarity: 206/404 - (50%)
• Gaps: 52/404 - (12%)

Human    47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHREN---LPSH----FKFKEYC 104
            ::|....|:.|::..|:..|...:|:.|.:      ::.:..|..|.   .|:|    |::|.|.
  Fly    80 IMGSIQLGIQHTVGSLASKPKRDLLMMDFW------EIESITFPPEGSSLTPAHHYSEFRYKIYA 138

Human   105 PQVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNL 166
            |..||..||.|||...|:::|:..:|..|  :.|:.|. |.::.|...:||.|..::...:...|
  Fly   139 PIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLL 203

Human   167 SNYHQYIVKCHGNTLLPQFLGMYRVSVDN-EDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASD 230
            ..|:..:.: :..||||:|.|:|.:...| ::..::||.|:....:.:|.|||||||...|:|:.
  Fly   204 PGYYMNLNQ-NPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANK 267

Human   231 KEKVKELPTLKDMDFLNKNQK-VYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDI---I 291
            .|:.|:.||.||:||:.::.. :::..|.....::.::||...|...||||||||||:|::   :
  Fly   268 AERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVAL 332

Human   292 RGSEPEEEAPVR---EDESEVDGDCSLTGPPA-------------LVGSYGTSPEGIGGY---IH 337
            :..:.|:..|:|   .::|:||.|..|.|..|             || ::.|:.|.|...   |.
  Fly   333 KEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLV-AHSTAMESIQAESEPID 396

Human   338 SHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEIST 402
            ....:.||...:       ||.:|  ::.:.::|:||||..|..|||..|..|::.|. |..:|.
  Fly   397 DEEDVPPGGIPA-------RSEKG--ERLLLYIGIIDILQSYRLKKKLEHTFKSIIHD-GETVSV 451

Human   403 VHPEQYAKRFLDFI 416
            ..|..||:||.:|:
  Fly   452 CRPSFYAQRFQNFM 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K2C	NP_079055.3	PIPKc_PIP5K2C	46..418	CDD:340448	120/404 (30%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000269|PubMed:31091439	69..75		1/5 (20%)
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	120/404 (30%)