Protein Alignment CA5A and CAH8

DIOPT Version :10

• Sequence 1: NP_001730.1
• Gene: CA5A / 763
• HGNCID: 1377
• Length: 305
• Species: Homo sapiens
• Sequence 2: NP_651033.2
• Gene: CAH8 / 42625
• FlyBaseID: FBgn0038956
• Length: 303
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 85/294 - (28%)
• Similarity: 129/294 - (43%)
• Gaps: 72/294 - (24%)

Human    30 PGRWCSQRSCAWQTSNNTLHPLWTVPVSVP--GGTRQSPINIQWRDSVYDP-QLKPLRVSYEAAS 91
            |.||                     |...|  ||:.||||.|..|.::  | .|.||      ..
  Fly    33 PERW---------------------PEKYPNCGGSEQSPIAISRRKAI--PLNLPPL------IF 68

Human    92 CLY---------IWNTGYLFQVEFDDATEASG----ISGGPLENHYRLKQFHFHWGAVNEGGSEH 143
            .||         |.|:|:  .|||...|...|    ::||.|.:.|..:..|||||:....||||
  Fly    69 ALYDEFFDELVTIRNSGH--TVEFKVPTTIYGVKPYVTGGLLRDCYDAEAVHFHWGSPESKGSEH 131

Human   144 TVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQR--LVDILPEIKHK 206
            .::|..:..|:|:||.|: ||.|.:|||...:|:.|:.|..|:........:  |.:|...:.|
  Fly   132 LLNGRRFDLEMHIVHRNT-KYLNLEEAVKYSDGVTVLAVLFKVVRSGPFFYQPGLSEIFSSLLH- 194

Human   207 DARAAMRPFDPS----------TLLPTC--WDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQL 259
                 :..|:.|          :||.:.  .:::||.|||||||.:..|.|.:..|.:.::...|
  Fly   195 -----LGNFNASYTVQERLTLGSLLGSLDRGNFYTYKGSLTTPPCSPVVQWHVFGEVLPISHQDL 254

Human   260 SAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVW 293
            ..|    ::...|..:.::.|:||||...||.::
  Fly   255 PKF----WNLRDERGRPLLKNFRPLQSQENRLIF 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CA5A	NP_001730.1	alpha_CA_V	61..296	CDD:239392	79/261 (30%)
CAH8	NP_651033.2	Carb_anhydrase	33..286	CDD:459707	85/294 (29%)