Protein Alignment CA5A and CAH7

DIOPT Version :10

• Sequence 1: NP_001730.1
• Gene: CA5A / 763
• HGNCID: 1377
• Length: 305
• Species: Homo sapiens
• Sequence 2: NP_649979.1
• Gene: CAH7 / 41238
• FlyBaseID: FBgn0037788
• Length: 304
• Species: Drosophila melanogaster
• Alignment Length: 285
• Identity: 85/285 - (29%)
• Similarity: 129/285 - (45%)
• Gaps: 52/285 - (18%)

Human    34 CSQRSCAW-------QTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSV-----------YDPQL 80
            |...|.:|       ...||...|..........|.:|||||:..:.::           ||...
  Fly    11 CCSVSFSWANEWGYPDLDNNQDEPFPKWGGLCDSGKKQSPINLHVKGALKGEFDALKFENYDEHQ 75

Human    81 KPLRVSYEAASCLYIWNTGYLFQVE-FDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHT 144
            |.||:.          |.|:..|:. ||....   :|||.|...:.::|.|.||      .||||
  Fly    76 KNLRMV----------NNGHSIQLSGFDHELT---LSGGALLQDFVVEQIHMHW------WSEHT 121

Human   145 VDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKL-GAHHQTLQRLVDILPEIKHKDA 208
            ::...||.|:|:||.|:: |.|...|...::|:.||||...: ...::.:..::..|..:|..|
  Fly   122 INDIRYPLEVHIVHRNTI-YPNMTMAANFKDGIVVIGVLYHVSNTPNEAIGSIIKSLGAVKSYD- 184

Human   209 RAAMRP------FDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLF 267
             :..:|      .....|:|:..:|:|||||||||...|:||||:..|...|...|::.|:.:.:
  Fly   185 -SMNKPVLVADSLAVDDLVPSVENYFTYAGSLTTPTCAEAVTWIVLTETFPVTLDQVNEFKEIEY 248

Human   268 SALGEEEKMMVNNYRPLQPLMNRKV 292
                :|.|.:.||||.||...||.|
  Fly   249 ----DEGKQLHNNYRELQSENNRAV 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CA5A	NP_001730.1	alpha_CA_V	61..296	CDD:239392	79/251 (31%)
CAH7	NP_649979.1	Carb_anhydrase	38..269	CDD:459707	78/256 (30%)